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7.4
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Journals
Microorganisms
Special Issues
Advances in Schistosome Research
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Advances in Schistosome Research

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Parasitology".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 1801

Special Issue Editors

Dr. Yang Hong

E-Mail Website
Guest Editor
National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention (Chinese Center for Tropical Diseases Research), Shanghai 200025, China
Interests: screening diagnostic markers, vaccine candidates and drug targets for schistosomiasis; pairing and laying eggs of schistosome; molecular diagnosis of parasites
Special Issues, Collections and Topics in MDPI journals
Dr. Jipeng Wang

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Co-Guest Editor
School of Life Sciences, Fudan University, Shanghai 200082, China
Interests: schistosome developmental biology; schistosome reproduction and egg production; anti-schistosomal drug development
Dr. Xi Sun

E-Mail Website
Co-Guest Editor
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510060, China
Interests: parasite and host interaction, parasite derived drug development

Special Issue Information

Dear Colleagues,

Schistosomiasis is a zoonotic parasitic disease which is endemic in 78 countries, with at least 251.4 million people requiring preventive treatment in 2021. It is also a disease of poverty that leads to chronic ill-health. The infection is prevalent in tropical and sub-tropical areas, in poor communities without potable water and adequate sanitation. Urogenital schistosomiasis is caused by Schistosoma haematobium and intestinal schistosomiasis by the S. mansoni, S. japonicum, S. guineensis, S. intercalatum, and S. mekongi organisms.

Although this disease is well controlled in certain areas, several million people all over the world suffer from severe morbidity as a consequence of schistosomiasis. The control and elimination of schistosomiasis will meet new challenges. Understanding the host-schistosome biology to a greater degree could help us to develop better, more appropriate interventions to achieve the goal.

This Special Issue focuses on the latest research development on the aspects of biology, infection, host–pathogen interactions, pathogenesis, diagnosis, drugs and vaccine development for control and prevention of schistosomiasis. We welcome prospective authors to contribute original research articles and review articles and share their experiences or point in this Special Issue.

Dr. Yang Hong
Dr. Jipeng Wang
Dr. Xi Sun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

15 pages, 2474 KiB  
Article
Metagenomic Analysis Reveals Variations in Gut Microbiomes of the Schistosoma mansoni-Transmitting Snails Biomphalaria straminea and Biomphalaria glabrata
by Peipei Li, Jinni Hong, Mingrou Wu, Zhanhong Yuan, Dinghao Li, Zhongdao Wu, Xi Sun and Datao Lin
Microorganisms 2023, 11(10), 2419; https://doi.org/10.3390/microorganisms11102419 - 28 Sep 2023
Cited by 2 | Viewed by 1390
Abstract
Biomphalaria snails play a crucial role in the transmission of the human blood fluke Schistosoma mansoni. The gut microbiota of intermediate hosts is known to influence their physiological functions, but little is known about its composition and role in Biomphalaria snails. To [...] Read more.
Biomphalaria snails play a crucial role in the transmission of the human blood fluke Schistosoma mansoni. The gut microbiota of intermediate hosts is known to influence their physiological functions, but little is known about its composition and role in Biomphalaria snails. To gain insights into the biological characteristics of these freshwater intermediate hosts, we conducted metagenomic sequencing on Biomphalaria straminea and B. glabrata to investigate variations in their gut microbiota. This study revealed that the dominant members of the gut microbiota in B. glabrata belong to the phyla Bacteroidetes and Proteobacteria, which were also found to be the top two most abundant gut bacteria in B. straminea. We identified Firmicutes, Acidovorax and Bosea as distinctive gut microbes in B. straminea, while Aeromonas, Cloacibacterium and Chryseobacterium were found to be dependent features of the B. glabrata gut microbiota. We observed significant differences in the community structures and bacterial functions of the gut microbiota between the two host species. Notably, we found a distinctive richness of antibiotic resistance genes (ARGs) associated with various classes of antibiotics, including bacitracin, chloramphenicol, tetracycline, sulfonamide, penicillin, cephalosporin_ii and cephalosporin_i, fluoroquinolone, aminoglycoside, beta-lactam, multidrug and trimethoprim, in the digestive tracts of the snails. Furthermore, this study revealed the potential correlations between snail gut microbiota and the infection rate of S. mansoni using Spearman correlation analysis. Through metagenomic analysis, our study provided new insights into the gut microbiota of Biomphalaria snails and how it is influenced by host species, thereby enhancing our understanding of variant patterns of gut microbial communities in intermediate hosts. Our findings may contribute to future studies on gastropod–microbe interactions and may provide valuable knowledge for developing snail control strategies to combat schistosomiasis in the future. Full article
(This article belongs to the Special Issue Advances in Schistosome Research)
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