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5.2
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Journals
Animals
Special Issues
Fish Diseases and Healthy Farming
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Fish Diseases and Healthy Farming

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Aquatic Animals".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 801

Special Issue Editors

Dr. Jing Dong

E-Mail Website
Guest Editor
Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China
Interests: fish diseases; virulence factors; fishery drugs; natural compounds; aquatic microbiology; antimicrobial resistance; bacterial virulence factors
Dr. Shun Zhou

E-Mail Website
Guest Editor
Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China
Interests: aquatic parasite disease; fish epidemiology; fishery drugs; parasitic pathogens; ecological and drug control

Special Issue Information

Dear Colleagues,

Aquatic products serve as a vital source of high-quality protein for global populations. However, infectious diseases in fish and other aquatic animals lead to significant economic losses and threaten the sustainability of aquaculture. The misuse of antibiotics and other fishery drugs further exacerbates risks to food safety, environmental health, and aquatic ecosystems.

This Special Issue, "Fish Diseases and Healthy Farming," focuses on the latest research in fish pathology, disease prevention, and sustainable aquaculture practices. Topics include emerging fish diseases, pathogenesis of fish pathogens and novel approaches dealing with infectious diseases in aquaculture. By advancing knowledge in these areas, we aim to enhance fish health, improve production efficiency, and support the long-term growth of the aquaculture industry.

We look forward to receiving your contributions to the special issue.

Dr. Jing Dong
Dr. Shun Zhou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fish diseases
  • pathogenesis
  • virulence factors
  • fishery drugs
  • drug discovery
  • antibiotics
  • vaccines
  • probiotics
  • immunology
  • antimicrobial resistance
  • disease prevention
  • healthy farming
  • sustainable aquaculture
  • genomics & disease-resistant breeding

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

18 pages, 9498 KB  
Article
Neuropeptide Y Boosts Intestinal Mucosal Immunity of Tilapia Infected with Streptococcus agalactiae by Reducing Inflammation and Oxidative Stress
by Yang Yu, Ziyan Liu, Mengyuan Zhou, Zexia Chen, Ran Cai, Chaowei Song, Meiqing Li, Tiansheng Zhu, Caiyun Sun and Wensheng Li
Animals 2025, 15(18), 2730; https://doi.org/10.3390/ani15182730 - 18 Sep 2025
Viewed by 152
Abstract
Neuropeptides and their corresponding receptors have been observed to play a significant role in modulating immune cell functions and epithelial barrier functions. In teleost, Neuropeptide Y (NPY) is identified to be involved in the immune regulation of intestinal tissues during bacterial infections. However, [...] Read more.
Neuropeptides and their corresponding receptors have been observed to play a significant role in modulating immune cell functions and epithelial barrier functions. In teleost, Neuropeptide Y (NPY) is identified to be involved in the immune regulation of intestinal tissues during bacterial infections. However, the mechanism of NPY on infected gastrointestinal tissue remains unclear, as does whether other members of the NPY family, like ligand PYYb and some receptors Y7 and Y8b, also contribute to this immunoregulatory process. Herein, the responses of PYYb and receptors Y7 and Y8b were explored after pathogen challenging, as well as the effect of NPY on the gastrointestinal tissues of Nile tilapia (Oreochromis niloticus). Using a NPY and S. agalactiae co-injection model, we measured the expression of pyyb, y7, and y8b and the inflammatory and oxidative stress responses in gastrointestinal tissues. S. agalactiae infection significantly upregulated pyyb expression, while co-treatment with NPY further amplified its expression. Infection caused an imbalance between y7 and y8b and was alleviated by NPY. Moreover, NPY contributed to immune protection. NPY co-treatment reduced inflammatory cytokine expression in the gastrointestinal tissues and alleviated tissue damage inflicted by S. agalactiae. Additionally, NPY mitigated immune and oxidative stress by enhancing lysozyme, AKP and ACP activities, normalizing glucose and albumin levels, and reducing lipid peroxidation (MDA). These findings demonstrated that PYYb and receptors Y7 and Y8b were involved in the immune response caused by S. agalactiae. NPY not only enhanced their reactions but also reduced inflammation and oxidative stress induced by the pathogen, indicating its potential as a therapeutic intervention for S. agalactiae infections in fish. Full article
(This article belongs to the Special Issue Fish Diseases and Healthy Farming)
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14 pages, 1429 KB  
Article
Transcriptomic Analysis Reveals the Inhibitory Mechanism of Fisetin Against the Pathogenicity of Aeromonas hydrophila
by Jing Dong, Xinwei Ma, Shengping Li, Shun Zhou, Qiuhong Yang and Xiaohui Ai
Animals 2025, 15(16), 2415; https://doi.org/10.3390/ani15162415 - 18 Aug 2025
Viewed by 424
Abstract
Aeromonas hydrophila is an important zoonotic bacterium that is related to multiple diseases in humans, terrestrial animals, and aquatic animals. Bacterial septicemia caused by A. hydrophila often results in high mortality and severe economic losses. Antibiotics, the major approach to dealing with bacterial [...] Read more.
Aeromonas hydrophila is an important zoonotic bacterium that is related to multiple diseases in humans, terrestrial animals, and aquatic animals. Bacterial septicemia caused by A. hydrophila often results in high mortality and severe economic losses. Antibiotics, the major approach to dealing with bacterial infections, are limited due to the occurrence of antibiotic resistance. Anti-virulence strategies provide a promising approach to combat resistant bacterial infections. Here, growth curves, hemolysis, biofilm formation, and animal studies were performed to investigate the effect of fisetin against A. hydrophila. Moreover, RNA-seq technology was employed to determine the potent mechanism of fisetin. The results showed that fisetin could dose-dependently reduce the hemolytic activities mediated by aerolysin and hinder biofilm formation. Animal studies showed that treatment with 50 mg/kg fisetin could remarkably reduce the mortality to 40% in the infected group compared with fish in the fisetin-free group. Further, transcriptome analysis demonstrated that there were 565 differentially expressed genes (DEGs) after treatment with 16 μg/mL fisetin. Fisetin significantly impacted the pathways related to oxidative phosphorylation, the citrate cycle, and virulence factor regulation. Furthermore, 159 virulence-related genes were influenced after fisetin treatment. Collectively, these findings revealed that fisetin could mitigate the pathogenicity of A. hydrophila by affecting oxidative phosphorylation and the citrate cycle pathway as well as inhibiting the production of virulence factors. The study not only identified a powerful substance for managing A. hydrophila-associated diseases in aquaculture but also clarified the mechanism of plant medicines in controlling diseases caused by bacterial pathogens. Full article
(This article belongs to the Special Issue Fish Diseases and Healthy Farming)
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