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Animals
Special Issues
Reproductive Endocrinology of Ruminants
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Reproductive Endocrinology of Ruminants

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Reproduction".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 931

Special Issue Editor

Dr. Davide Rondina

E-Mail Website
Guest Editor
Faculdade de Veterinária, Universidade Estadual do Ceará, Fortaleza 60714-903, Brazil
Interests: ruminants; endocrine–metabolic control in reproduction; follicular development; ovary; fertilization; early embryonic development; fetal development; epigenetic control in reproduction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Much remains to be discovered about endocrine function in ruminant reproduction. We are pleased to invite the presentation of original research on endocrine–metabolic function and how it acts on sexual development, function, and reproduction. The topics in this Special Issue will address the mechanisms of action of hormones and their related molecules with regard to fertility, the fertilization process, early embryonic development, embryo–uterus interactions, and the different stages of pregnancy. Therefore, we welcome contributions related to the endocrine pathophysiology of reproductive tract disorders, the effects of EDCs, as well as reproductive immunology and reproductive control in domestic and wild ruminant species.

Dr. Davide Rondina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproductive biology and endocrinology
  • regulation of hormone secretion
  • molecular and cellular endocrinology
  • metabolomics
  • hormone–receptor interactions and hormonal signaling
  • disorders of the reproductive endocrinological system
  • epigenetic mechanism of regulation and molecular genetics

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Published Papers (1 paper)

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Research

18 pages, 11452 KiB  
Article
Inhibition of Prolactin Affects Epididymal Morphology by Decreasing the Secretion of Estradiol in Cashmere Bucks
by Xiaona Liu, Chunhui Duan, Xuejiao Yin, Lechao Zhang, Meijing Chen, Wen Zhao, Xianglong Li, Yueqin Liu and Yingjie Zhang
Animals 2024, 14(12), 1778; https://doi.org/10.3390/ani14121778 - 13 Jun 2024
Viewed by 707
Abstract
Yanshan Cashmere bucks are seasonal breeding animals and an important national genetic resource. This study aimed to investigate the involvement of prolactin (PRL) in the epididymal function of bucks. Twenty eleven-month-old Cashmere bucks were randomly divided into a control (CON) group and a [...] Read more.
Yanshan Cashmere bucks are seasonal breeding animals and an important national genetic resource. This study aimed to investigate the involvement of prolactin (PRL) in the epididymal function of bucks. Twenty eleven-month-old Cashmere bucks were randomly divided into a control (CON) group and a bromocriptine (BCR, a prolactin inhibitor, 0.06 mg/kg body weight (BW)) treatment group. The experiment was conducted from September to October 2020 in Qinhuangdao City, China, and lasted for 30 days. Blood was collected on the last day before the BCR treatment (day 0) and on the 15th and 30th days after the BCR treatment (days 15 and 30). On the 30th day, all bucks were transported to the local slaughterhouse, where epididymal samples were collected immediately after slaughter. The left epididymis was preserved in 4% paraformaldehyde for histological observation, and the right epididymis was immediately preserved in liquid nitrogen for RNA sequencing (RNA-seq). The results show that the PRL inhibitor reduced the serum PRL and estradiol (E2) concentrations (p < 0.05) and tended to decrease luteinizing hormone (LH) concentrations (p = 0.052) by the 30th day, but no differences (p > 0.05) occurred by either day 0 or 15. There were no differences (p > 0.05) observed in the follicle-stimulating hormone (FSH), testosterone (T), and dihydrotestosterone (DHT) concentrations between the two groups. The PRL receptor (PRLR) protein was mainly located in the cytoplasm and intercellular substance of the epididymal epithelial cells. The PRL inhibitor decreased (p < 0.05) the expression of the PRLR protein in the epididymis. In the BCR group, the height of the epididymal epithelium in the caput and cauda increased, as did the diameter of the epididymal duct in the caput (p < 0.05). However, the diameter of the cauda epididymal duct decreased (p < 0.05). Thereafter, a total of 358 differentially expressed genes (DEGs) were identified in the epididymal tissues, among which 191 were upregulated and 167 were downregulated. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed that ESR2, MAPK10, JUN, ACTL7A, and CALML4 were mainly enriched in the estrogen signaling pathway, steroid binding, calcium ion binding, the GnRH signaling pathway, the cAMP signaling pathway, and the chemical carcinogenesis–reactive oxygen species pathway, which are related to epididymal function. In conclusion, the inhibition of PRL may affect the structure of the epididymis by reducing the expression of the PRLR protein and the secretion of E2. ESR2, MAPK10, JUN, ACTL7A, and CALML4 could be the key genes of PRL in its regulation of epididymal reproductive function. Full article
(This article belongs to the Special Issue Reproductive Endocrinology of Ruminants)
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