Comparative Oncology in Animals: Advancements in Diagnostics and Treatment

A special issue of Animals (ISSN 2076-2615).

Deadline for manuscript submissions: 30 October 2024 | Viewed by 906

Special Issue Editor


E-Mail Website
Guest Editor
Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland
Interests: animal physiology; immune-oncology; NK cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development of veterinary medicine regarding the oncology of companion animals has effected the need to extend research in the field to cats and dogs, which have a long lifespan and are often affected by cancer. As many diagnostic and treatment techniques have been adopted directly from human medicine, it has become obvious that we can learn from each other's experiences. However, veterinary medicine is also divided into many branches depending on the particular species. Therefore, not only the species but also the breed can have a significant effect on the efficiency of therapy. The breed, sex, spaying status, and age at spaying of the animal are only a few examples of the factors that may have an influence on the patient. Moreover, the environmental conditions in different regions of the world can affect the type of cancer experienced by animals. Advances in genetics have allowed us to compare the genome of many animal species with the human genome, as well as the activation of many signaling pathways in response to a given agent; thus, the use of comparative oncology can contribute to the development of veterinary oncology also.  

On the other hand, we have to be aware that the utilization of human models for veterinary medicine has limitations and will never replace clinical studies on animals, despite offering benefits regarding the diagnosis and treatment of many cancers in animals.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: comparative and translational studies of prognostic and predictive biomarkers in oncology; the study of tumor progression; the evaluation of novel cancer strategies in animals; and therapies that can be translated to other species.

Dr. Joanna Mucha
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • comparative oncology
  • veterinary oncology
  • novel oncotherapies
  • cancer
  • translational medicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 8305 KiB  
Article
Preliminary Evidence of the Possible Roles of the Ferritinophagy-Iron Uptake Axis in Canine Testicular Cancer
by Rebecca Leandri, Karen Power, Sara Buonocore and Gionata De Vico
Animals 2024, 14(17), 2619; https://doi.org/10.3390/ani14172619 - 9 Sep 2024
Viewed by 604
Abstract
Iron is a key element in spermatogenesis; its metabolic pathway in the testis is strictly regulated. Alterations in iron metabolism are linked to various diseases, including cancer, and changes in iron metabolism-related proteins have been observed in multiple human, mouse and canine tumors. [...] Read more.
Iron is a key element in spermatogenesis; its metabolic pathway in the testis is strictly regulated. Alterations in iron metabolism are linked to various diseases, including cancer, and changes in iron metabolism-related proteins have been observed in multiple human, mouse and canine tumors. There is limited knowledge about iron metabolism in canine non-neoplastic and neoplastic testes. This study aimed to explore the immunohistochemical expression of molecules involved in iron uptake and storage [Transferrin Receptor 1 (TfR1), ferritin (FTH1), nuclear receptor coactivator 4 (NCOA4)] and PCNA in canine non-neoplastic and neoplastic testicular samples. Non-neoplastic testes showed moderate TfR1 expression in developing germ cells and Sertoli cells, high NCOA4 cytoplasmic immunostaining in the Sertoli cells and occasional cytoplasmic immunopositivity for FTH1 in the spermatogonia and Sertoli cells. In contrast, Leydig cell tumors (LCTs) and Diffuse Type Seminoma (DSEM) exhibited increased expression of TfR1, along with higher PCNA expression, suggesting a higher iron need for proliferation. Intratubular Type Seminoma (ITSEM) showed a higher FTH1 expression, indicating greater iron storage, while the increased NCOA4 expression in the LCTs and DSEM suggested ferritinophagy to release iron for proliferation. Sertoli cell tumors (SCTs) showed only NCOA4 expression. These preliminary findings highlight potential molecular targets for developing new anti-neoplastic treatments in canine testicular tumors. Full article
Show Figures

Figure 1

Back to TopTop