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Animals
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Animal Cloning
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Animal Cloning

A special issue of Animals (ISSN 2076-2615).

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 6417

Special Issue Editor

Dr. Muren Herrid

E-Mail Website
Guest Editor
International Livestock Research Centre, Gold Coast 4211, Australia
Interests: in vitro fertilization (IVF); embryo vitrification; stem cell biology; animal cloning; animal breeding
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Animal cloning, scientifically known as somatic cell nuclear transfer (SCNT), is an advanced reproductive technology which has potential application in various aspects of bioscience and biotechnology, such as livestock breeding, endangered species preservation, organ xenotransplantation, and transgenic animal generation. Recently, SCNT has also shown great potential in epigenetics research, where it is employed to reprogram the somatic cell genome into a totipotent state equivalent to that of the fertilized oocyte.

Although handmade cloning has improved the efficiency of traditional cloning, with the potential for use in commercial settings, the wider application of the technique is still limited due to the high incidence of developmental abnormalities and lower pregnancy rate.

We invite original research papers that address methods and approaches in animal cloning for improving its efficiency, with special interest in handmade cloning, the cryopreservation of cloned embryos, and interspecies cloning.

Dr. Muren Herrid
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cloning
  • somatic cell nuclear transfer
  • pregnancy rate
  • cryopreservation
  • handmade cloning
  • reprogramming

Published Papers (2 papers)

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Research

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20 pages, 4262 KiB  
Article
Effects of Crotonylation on Reprogramming of Cashmere Goat Somatic Cells with Different Differentiation Degrees
by Wennan Li, Wei Yan, Fei Hao, Lingyun Hao and Dongjun Liu
Animals 2022, 12(20), 2848; https://doi.org/10.3390/ani12202848 - 19 Oct 2022
Cited by 2 | Viewed by 1568
Abstract
Failure in the epigenetic reprogramming of somatic cells is considered the main reason for lower cloned embryo development efficiency. Lysine crotonylation (Kcr) occupies an important position in epigenetic modification, while its effects on somatic cell reprogramming have not been reported. In this study, [...] Read more.
Failure in the epigenetic reprogramming of somatic cells is considered the main reason for lower cloned embryo development efficiency. Lysine crotonylation (Kcr) occupies an important position in epigenetic modification, while its effects on somatic cell reprogramming have not been reported. In this study, we detected the influence of sodium crotonate (NaCr) on the Kcr levels in three types of somatic cells (muscle-derived satellite cells, MDSCs; fetal fibroblast cells, FFCs; and ear tip fibroblast cells, EFCs). The three types of somatic cells were treated with NaCr for cloned embryo construction, and the cleavage rates and Kcr, H3K9cr, and H3K18cr levels in the cloned embryos were analyzed. The results showed that the abnormal levels of Kcr, H3K9cr, and H3K18cr were corrected in the treatment groups. Although there was no significant difference in the cloned embryo cleavage rate in the FFC treatment group, the cleavage rates of the cloned embryos in the MDSCs and EFCs treatment groups were increased. These findings demonstrated that the Kcr level was increased with NaCr treatment in somatic cells from Cashmere goat, which contributed to proper reprogramming. The reprogramming of somatic cells can be promoted and cloned embryo development can be improved through the treatment of somatic cells with NaCr. Full article
(This article belongs to the Special Issue Animal Cloning)
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Review

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18 pages, 1839 KiB  
Review
iPSC Technology: An Innovative Tool for Developing Clean Meat, Livestock, and Frozen Ark
by Rajneesh Verma, Younghyun Lee and Daniel F. Salamone
Animals 2022, 12(22), 3187; https://doi.org/10.3390/ani12223187 - 17 Nov 2022
Cited by 3 | Viewed by 3114
Abstract
Induced pluripotent stem cell (iPSC) technology is an emerging technique to reprogram somatic cells into iPSCs that have revolutionary benefits in the fields of drug discovery, cellular therapy, and personalized medicine. However, these applications are just the tip of an iceberg. Recently, iPSC [...] Read more.
Induced pluripotent stem cell (iPSC) technology is an emerging technique to reprogram somatic cells into iPSCs that have revolutionary benefits in the fields of drug discovery, cellular therapy, and personalized medicine. However, these applications are just the tip of an iceberg. Recently, iPSC technology has been shown to be useful in not only conserving the endangered species, but also the revival of extinct species. With increasing consumer reliance on animal products, combined with an ever-growing population, there is a necessity to develop alternative approaches to conventional farming practices. One such approach involves the development of domestic farm animal iPSCs. This approach provides several benefits in the form of reduced animal death, pasture degradation, water consumption, and greenhouse gas emissions. Hence, it is essentially an environmentally-friendly alternative to conventional farming. Additionally, this approach ensures decreased zoonotic outbreaks and a constant food supply. Here, we discuss the iPSC technology in the form of a “Frozen Ark”, along with its potential impact on spreading awareness of factory farming, foodborne disease, and the ecological footprint of the meat industry. Full article
(This article belongs to the Special Issue Animal Cloning)
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