Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.9
2.7
Journals
Animals
Special Issues
Tumors in Companion Animals: Epidemiology, Biology and Comparative Features
share announcement

Tumors in Companion Animals: Epidemiology, Biology and Comparative Features

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Companion Animals".

Deadline for manuscript submissions: closed (23 October 2023) | Viewed by 13447

Special Issue Editor

Dr. Marta Vascellari

E-Mail Website
Guest Editor
Istituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, PD, Italy
Interests: veterinary oncology; epidemiology; pathology; infectious diseases

Special Issue Information

Dear Colleagues,

Due to the increasing incidence of cancer in companion animals, accompanied by improvements in diagnostic and therapeutic strategies, oncology has become a growing topic in veterinary medicine. Common cancers found in companion animals represent reliable models of human cancer. Consequently, the results acquired from veterinary studies may be useful to improve prevention strategies, deepen pathogenesis, and evaluate the effectiveness and safety of new cancer therapies for both humans and animals. Furthermore, considering the role of companion animals as sentinels of human neoplastic diseases, accurate surveillance data can be utilized to monitor the burden of cancer worldwide, to set strategies for cancer prevention and control, and to highlight associations between exposure and cancer risk.

In this Special Issue, original research articles and reviews are welcome. We look forward to receiving your contributions.

Dr. Marta Vascellari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • companion animals
  • epidemiology
  • diagnosis
  • histology
  • biomarkers
  • pathway
  • risk factors
  • therapy
  • prognosis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 1146 KiB  
Article
E-Cadherin Immunostaining in Equine Melanocytic Tumors
by José Pimenta, Isabel Pires, Justina Prada and Mário Cotovio
Animals 2023, 13(13), 2216; https://doi.org/10.3390/ani13132216 - 6 Jul 2023
Cited by 3 | Viewed by 1405
Abstract
Melanocytic tumors are an important neoplastic disease in human and veterinary medicine, presenting large differences regarding tumor behavior between species. In horses, these tumors present a prolonged benign behavior, with rare invasiveness and metastases. In humans and small animals, invasion and metastasis have [...] Read more.
Melanocytic tumors are an important neoplastic disease in human and veterinary medicine, presenting large differences regarding tumor behavior between species. In horses, these tumors present a prolonged benign behavior, with rare invasiveness and metastases. In humans and small animals, invasion and metastasis have been associated with an Epithelial-Mesenchymal Transition, where the loss of E-cadherin expression plays a key role in tumor progression. This process and the role of E-cadherin have not yet been evaluated in equine melanocytic tumors. This study aimed to assess the immunolabeling of E-cadherin in equine melanocytic tumors and relate this with clinicopathological variables. A total of 72 equine melanocytic tumors were classified as benign and malignant and evaluated by immunohistochemistry for E-cadherin expression. A different pattern of immunostaining was found, contrasting with other species. A total of 69.4% of tumors presented raised immunolabeling of E-cadherin, with 70.7% of melanomas remaining with high expression. The typical loss of immunostaining was not seen in malignant melanomas and no differences were found between benign and malignant melanomas regarding E-cadherin immunostaining. The high immunolabeling of E-cadherin may contribute to the low invasiveness of these tumors, and it is in accordance with the benign behavior of equine melanoma and with the genetic factors associated with its development. Full article
(This article belongs to the Special Issue Tumors in Companion Animals: Epidemiology, Biology and Comparative Features)
►▼ Show Figures

Figure 1

17 pages, 3833 KiB  
Article
Comparative Study of Digital Squamous Cell Carcinoma in Giant, Standard, and Miniature Schnauzers
by Heike Aupperle-Lellbach, Daniela Heidrich, David Conrad, Christoph Beitzinger, Nives Masala, Robert Klopfleisch and Tobias Müller
Animals 2023, 13(12), 1990; https://doi.org/10.3390/ani13121990 - 14 Jun 2023
Cited by 1 | Viewed by 8012
Abstract
In schnauzers, a breed predisposition to squamous cell carcinoma of the digit (dSCC) is well known. The aim of this study was to compare the clinical and macroscopic findings of dSCCs in giant (GSs), standard (SSs), and miniature schnauzers (MSs). Methods: Pathology reports [...] Read more.
In schnauzers, a breed predisposition to squamous cell carcinoma of the digit (dSCC) is well known. The aim of this study was to compare the clinical and macroscopic findings of dSCCs in giant (GSs), standard (SSs), and miniature schnauzers (MSs). Methods: Pathology reports of 478 dSCCs from 417 schnauzers (227 GSs, 174 SSs, and 16 MSs) were retrospectively evaluated. Results: The MSs were older than the SSs and GSs (p ≤ 0.01). The male GSs were predisposed to dSCC (p < 0.05). In the GSs, the nodular dSCCs were larger than in the MSs (p ≤ 0.05) and SSs (p ≤ 0.001). The digital SCCs were mostly diagnosed at the forelimbs, especially at digits 1, 2, and 5. At the hindlimbs, the affected toes differed between the GSs and SSs. Multiple dSCCs were more common in SSs than in GSs (p = 0.003). If dSCC was the cause of death, the survival time was shorter than in dogs dying from other diseases (p = 0.004). Metastases occurred in 20% of the cases and led to a significantly shorter survival time in both the GSs and SSs (p < 0.001). Conclusions: The results showed various differences in the dSCC depending on the size variant of the schnauzer. Full article
(This article belongs to the Special Issue Tumors in Companion Animals: Epidemiology, Biology and Comparative Features)
►▼ Show Figures

Figure 1

15 pages, 1826 KiB  
Article
Immunohistochemical and Molecular Genetic Analysis of Canine Digital Mast Cell Tumours
by David Conrad, Alexandra Kehl, Tobias Müller, Robert Klopfleisch and Heike Aupperle-Lellbach
Animals 2023, 13(10), 1694; https://doi.org/10.3390/ani13101694 - 19 May 2023
Cited by 2 | Viewed by 3312
Abstract
Grading, immunohistochemistry and c-kit mutation status are criteria for assessing the prognosis and therapeutic options of canine cutaneous mast cell tumours (MCTs). As a subset, canine digital MCTs have rarely been explored in this context. Therefore, in this retrospective study, 68 paraffin-embedded canine [...] Read more.
Grading, immunohistochemistry and c-kit mutation status are criteria for assessing the prognosis and therapeutic options of canine cutaneous mast cell tumours (MCTs). As a subset, canine digital MCTs have rarely been explored in this context. Therefore, in this retrospective study, 68 paraffin-embedded canine digital MCTs were analysed, and histological grading was assessed according to Patnaik and Kiupel. The immunohistochemical markers KIT and Ki67 were used, as well as polymerase chain reaction (PCR) for mutational screening in c-kit exons 8, 9, 11 and 14. Patnaik grading resulted in 22.1% grade I, 67.6% grade II and 10.3% grade III tumours. Some 86.8% of the digital MCTs were Kiupel low-grade. Aberrant KIT staining patterns II and III were found in 58.8%, and a count of more than 23 Ki67-positive cells in 52.3% of the cases. Both parameters were significantly associated with an internal tandem duplication (ITD) in c-kit exon 11 (12.7%). French Bulldogs, which tend to form well-differentiated cutaneous MCTs, had a higher proportion of digital high-grade MCTs and ITD in c-kit exon 11 compared with mongrels. Due to its retrospective nature, this study did not allow for an analysis of survival data. Nevertheless, it may contribute to the targeted characterisation of digital MCTs. Full article
(This article belongs to the Special Issue Tumors in Companion Animals: Epidemiology, Biology and Comparative Features)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop