Strategies for Combatting Multidrug-Resistant and Extensively Drug-Resistant Bacteria, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "The Global Need for Effective Antibiotics".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 477

Special Issue Editors


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Guest Editor
Department of Microbiology, University of Wroclaw, Wroclaw, Poland
Interests: cross-resistance; antibiotic resistance; efflux pumps; Salmonella
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Microbiology, University of Wroclaw, Wroclaw, Poland
Interests: silver nanoparticles; alternative therapy; bacterial resistance

Special Issue Information

Dear Colleagues,

The first volume of the Special Issue “Strategies for Combatting Multidrug-Resistant and Extensively Drug-Resistant Bacteria: Current Challenges and Future Prospects ” was published in October 2023. It is a successful issue with nine published papers, encouraging us to open a second volume on the same topic.

As a continuation of the first Special Issue, this second volume will also focus on new strategies, including those that are not only related to novel antimicrobial drugs, but also those related to uncommon drug strategies. The topics of interest include, but are not limited to, the following:

  • MDR bacteria;
  • EDR bacteria;
  • Novel antimicrobial drugs;
  • Novel therapeutical approaches against MDR;
  • Novel therapeutical approaches against EDR;
  • Guidelines;
  • Personalized microbiota;
  • Bacteriophages;
  • Autovaccine therapy;
  • Antimicrobial stewardship.

Dr. Bożena Futoma-Kołoch
Dr. Anna Kędziora
Guest Editors

Manuscript Submission Information

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Keywords

  • MDR bacteria
  • EDR bacteria
  • novel antimicrobial drugs
  • novel therapeutical approaches against MDR
  • novel therapeutical approaches against EDR
  • guidelines
  • personalized microbiota
  • bacteriophages
  • autovaccine therapy
  • antimicrobial stewardship

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Published Papers (1 paper)

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Research

19 pages, 2073 KiB  
Article
Exploring Biofilm-Related Traits and Bile Salt Efficacy as Anti-Biofilm Agents in MDR Acinetobacter baumannii
by Verica Aleksic Sabo, Dušan Škorić, Suzana Jovanović-Šanta and Petar Knezevic
Antibiotics 2024, 13(9), 880; https://doi.org/10.3390/antibiotics13090880 - 13 Sep 2024
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Abstract
Acinetobacter baumannii has been designated as a critical priority pathogen by the World Health Organization for the development of novel antimicrobial agents. This study aimed to investigate both the phenotypic and genotypic traits of multidrug-resistant (MDR) A. baumannii strains, along with the effects [...] Read more.
Acinetobacter baumannii has been designated as a critical priority pathogen by the World Health Organization for the development of novel antimicrobial agents. This study aimed to investigate both the phenotypic and genotypic traits of multidrug-resistant (MDR) A. baumannii strains, along with the effects of natural bile salts on biofilm formation. The research analyzed phenotypic traits, including autoaggregation, hydrophobicity, twitching motility, lectin production, and biofilm formation, as well as genotypic traits such as the presence of bap and blaPER-1 genes in twenty wound and eight environmental MDR A. baumannii isolates. While all strains were identified as good biofilm producers, no statistically significant correlation was detected between the examined traits and biofilm formation. However, differences in biofilm production were observed between environmental and wound isolates. The natural bile salts Na-cholate, Na-deoxycholate, and Na-chenodeoxycholate demonstrated effective anti-A. baumannii activity (MIC = 0.25–10 mg mL−1), with significant anti-biofilm effects. Na-deoxycholate and Na-chenodeoxycholate inhibited 94–100% of biofilm formation at super-MIC concentrations (8–32 mg mL−1). This study underscores the urgent need for innovative strategies to combat antibiotic resistance and biofilm formation in A. baumannii, highlighting the potential of natural bile salts as promising biofilm inhibitors and encouraging further research into their modification and combination with other antimicrobials. Full article
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