Virulence, Antimicrobial Resistance and Biofilm Production in Veterinary, Zoonotic and Food-Related Pathogens

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 31 January 2025 | Viewed by 995

Special Issue Editors


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Guest Editor
Department of Animal Health, Universidad de León, León, Spain
Interests: antimicrobial resistance; biofilm; genomics; microbiology; microbiome; veterinary pathogens; zoonosis

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Guest Editor
Department of Food Hygiene and Technology, Universidad de León, León, Spain
Interests: biofilm; fermented beverages; food-related pathogens; microbial dynamics; microbiome

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Guest Editor
Department of Animal Health, Universidad de León, León, Spain
Interests: antimicrobial resistance; biofilm; microbiology; porcine respiratory disease complex; vaccination
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Special Issue Information

Dear Colleagues,

The emergence and persistence of virulent, antimicrobial-resistant pathogens in veterinary and food-related environments pose significant threats to both animal and human health. This Special Issue aims to explore the complex interplay between virulence factors, antimicrobial resistance mechanisms, and biofilm production in veterinary, zoonotic, and food-related pathogens.

Understanding these interactions is critical for developing effective strategies to control infections, ensure food safety, and mitigate the spread of resistance. Contributions to this issue will encompass a range of topics, including the molecular mechanisms underlying virulence and resistance, the impact of biofilm formation on pathogen survival and treatment efficacy, and innovative approaches for detection and intervention.

By bringing together cutting-edge research from leading experts, this Special Issue seeks to provide a comprehensive overview of current challenges and advancements in the field. We aim to foster interdisciplinary collaboration and inspire new insights that can lead to improved therapeutic and preventative measures.

Through a deeper understanding of these critical aspects of pathogen biology, we hope to contribute to the development of more effective policies and practices that safeguard animal health, food security, and public health.

Dr. Óscar Mencía-Ares
Dr. Paula Fernández-Gómez
Dr. Sonia Martinez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal health
  • antimicrobial resistance
  • biofilm
  • food-borne pathogens
  • microbiology
  • pathogenicity
  • public health
  • veterinary pathogens
  • virulence
  • zoonosis

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Published Papers (1 paper)

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Research

15 pages, 2988 KiB  
Article
Insights into the Virulence and Antimicrobial Resistance of Staphylococcus hyicus Isolates from Spanish Swine Farms
by Oscar Mencía-Ares, Eva Ramos-Calvo, Alba González-Fernández, Álvaro Aguarón-Turrientes, Ana Isabel Pastor-Calonge, Rubén Miguélez-Pérez, César B. Gutiérrez-Martín and Sonia Martínez-Martínez
Antibiotics 2024, 13(9), 871; https://doi.org/10.3390/antibiotics13090871 - 11 Sep 2024
Viewed by 829
Abstract
Staphylococcus hyicus is a significant pathogen in swine, primarily causing exudative epidermitis. Addressing S. hyicus infections requires both the characterization of virulence and antimicrobial resistance (AMR) in farm-recovered isolates. This study aimed to characterize the virulence, AMR, and biofilm formation of S. hyicus [...] Read more.
Staphylococcus hyicus is a significant pathogen in swine, primarily causing exudative epidermitis. Addressing S. hyicus infections requires both the characterization of virulence and antimicrobial resistance (AMR) in farm-recovered isolates. This study aimed to characterize the virulence, AMR, and biofilm formation of S. hyicus isolates from Spanish swine farms. A total of 49 isolates were analyzed, originating from animals with cutaneous, reproductive, and systemic clinical signs. Half of the isolates (49.0%) were positive for at least one virulence factor (VF) gene, with SHETA being the most frequent (28.6%). A high frequency of multidrug resistant (MDR) isolates was observed (83.7%), with significant resistance to commonly used antimicrobials, including lincosamides (83.7%), pleuromutilins (81.6%), penicillins (75.5%), and tetracyclines (73.5%). All isolates exhibited robust in vitro biofilm formation capacity (DC = 15.6 ± 7.0). Significant associations were found between VFs, biofilm formation, and AMR patterns, highlighting the link between the resistance to lincosamides and pleuromutilins (p < 0.001; Φ = 0.57) and macrolides (p < 0.001; Φ = 0.48), and the association of AMR with the ExhC and ExhD VF genes. These findings underscore the need for targeted diagnostics to improve management and therapeutic strategies to mitigate the impact of S. hyicus on swine production. Full article
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