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Antibiotics
Special Issues
Novelties in Antibiotic Therapy, Microbial Resistance and Best Stewardship Practices
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Novelties in Antibiotic Therapy, Microbial Resistance and Best Stewardship Practices

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1024

Special Issue Editors

Dr. Islam M. Ghazi

E-Mail Website
Guest Editor
Arnold and Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY, USA
Interests: clinical trials; preclinical lab work including animal and invitro models; data collection and analysis; contributing to development; optimization and stewardship for antibacterial agents
Special Issues, Collections and Topics in MDPI journals
Dr. Wasim S. El Nekidy

E-Mail Website
Guest Editor
1. Department of Pharmacy Services, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates
2. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA
Interests: drug dosing; kidney diseases; sepsis; antibiotics

Special Issue Information

Dear Colleagues,

The world of microorganisms continues to bedazzle us with its outstanding ability to adapt and evade our defense of discovered drugs. Unfortunately, this evolution poses a paramount burden on health care systems around the globe. Treatment of patients infected with resistant microorganisms is associated with high morbidity and mortality along with the consumption of sizable financial resources. Research provides insights into several aspects such as new drug discovery, the repurposing of available antimicrobials, tracking microbial resistance, optimizing clinical outcomes and devising antimicrobial stewardship policies and procedures. These strides have the overall aim of preserving our ability to treat infectious diseases and halting the reversion to the pre-antibiotic era. In this Special Issue, we welcome submissions from all over the world that would shed light on developing new antimicrobials, addressing gaps in antimicrobial therapy and refining antimicrobial stewardship practices.

Dr. Islam M. Ghazi
Dr. Wasim S. El Nekidy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbial resistance
  • antimicrobial stewardship
  • antibiotics
  • animal Models
  • in vitro models
  • pharmacokinetics/pharmacodynamics

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Published Papers (1 paper)

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Research

9 pages, 231 KiB  
Article
Clinical Outcomes of Ceftazidime–Avibactam versus Ceftolozane–Tazobactam in Managing Pseudomonal Infections in Patients Undergoing Renal Replacement Therapy
by Wasim S. El Nekidy, Mooza Al Ali, Emna Abidi, Rania El Lababidi, Diaa Alrahmany, Islam M. Ghazi, Mohamad Mooty, Fadi Hijazi, Muriel Ghosn and Jihad Mallat
Antibiotics 2024, 13(8), 699; https://doi.org/10.3390/antibiotics13080699 - 26 Jul 2024
Viewed by 811
Abstract
The optimal doses of ceftazidime–avibactam (CZA) and ceftolozane–tazobactam (C/T) for treating multidrug-resistant (MDR) Pseudomonas aeruginosa (PSA) in patients utilizing renal replacement therapy (RRT) are not well established. Hence, the objective of this study is to evaluate the clinical outcomes associated with the suggested [...] Read more.
The optimal doses of ceftazidime–avibactam (CZA) and ceftolozane–tazobactam (C/T) for treating multidrug-resistant (MDR) Pseudomonas aeruginosa (PSA) in patients utilizing renal replacement therapy (RRT) are not well established. Hence, the objective of this study is to evaluate the clinical outcomes associated with the suggested doses of CZA and C/T in patients with PSA infection utilizing RRT. Methods: This is a retrospective study conducted at our hospital between September 2018 and March 2022. Clinical cure was the primary endpoint, while microbiologic cure, 30-day recurrence, and 30-day mortality were the secondary endpoints. Results: In total, 45 subjects met the inclusion criteria, with 25 receiving CZA and 20 receiving C/T. The median age was 69 (52–81) and 69 (61.5–83) years, respectively, while the median weight was 70 (55.5–81.5) and 66 (57–79) kg, respectively. Clinical cure was achieved in 12 (48%) subjects in the CZA group and 12 (60%) in the C/T group (p = 0.432). Of the 36 subjects who had repeated cultures, a microbiologic cure was achieved in 14/23 (60%) subjects and 10/13 (76.9%) subjects (p = 0.273). Thirty-day recurrence was reported in 3 (12%) cases in the CZA group and 6 (30%) in the C/T group (p = 0.082). The 30-day mortality was 13 (52%) subjects in the CZA group and 10 (50%) in the C/T group (p = 0.894). The median maintenance dose of CZA was 1.88 (0.94–3.75) g and 2.25 (1.5–2.25) g for C/T. Multivariate logistic regression analysis indicated that both drugs did not differ significantly in clinical cure. Bloodstream infection (BSI) (OR = 25, 95% CI: 1.63–411.7, p = 0.021) was the only independent factor associated with clinical cure in this population. Conclusions: Our findings indicated that C/T and CZA did not significantly differ in achieving clinical cure in patients with MDR PSA infections undergoing RRT. Larger clinical trials are needed to confirm our findings. Full article
(This article belongs to the Special Issue Novelties in Antibiotic Therapy, Microbial Resistance and Best Stewardship Practices)
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