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Antibiotics
Special Issues
Antimicrobial Activity of Bioactive Peptides and Their Derivatives
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Antimicrobial Activity of Bioactive Peptides and Their Derivatives

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Peptides".

Deadline for manuscript submissions: closed (15 June 2024) | Viewed by 1394

Special Issue Editor

Dr. Alexandro Rodríguez-Rojas

E-Mail Website
Guest Editor
Department for Small Animal Internal Medicine, Clinic for Small Animals, University of Veterinary Medicine, Vienna, Austria
Interests: antimicrobial peptides; antimicrobials; host-pathogen interaction; infectious diseases; antimicrobial mechanism of action; bacterial genetics

Special Issue Information

Dear Colleagues,

The emergence and rapid spread of antimicrobial-resistant (AMR) microorganisms pose a significant global health threat. In the face of this growing challenge, there is an urgent need for novel antimicrobial agents with effective and broad-spectrum activity. Bioactive peptides (AMPs) represent a promising new class of antimicrobials that offer several advantages over traditional antibiotics. AMPs are naturally occurring peptides in various organisms, including humans, animals, plants, and microbes. They exhibit a broad spectrum of activity against several pathogens, including bacteria, fungi, and viruses.

Additionally, AMPs are less prone to developing resistance than traditional antibiotics. This Special Issue of Antibiotics will focus on the latest research on the antimicrobial activity of bioactive peptides and their derivatives. The issue will include articles on novel AMPs or their derivatives with potent antimicrobial activity, mechanisms of action of AMPs, structure–activity relationships of AMPs, development of AMP-based therapeutics, clinical applications of AMPs, and combinatory therapy with other antimicrobials.

Dr. Alexandro Rodríguez-Rojas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance (AMR)
  • global health threat
  • novel antimicrobial agents
  • bioactive peptides (AMPs)
  • natural antimicrobial agents
  • broad-spectrum activity
  • antimicrobial activity
  • mechanisms of action
  • structure–activity relationships
  • AMP-based therapeutics
  • clinical applications of AMPs
  • combinatory therapy

Published Papers (2 papers)

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Research

11 pages, 1689 KiB  
Article
A Cyclic Peptide Based on Pheasant Cathelicidin Inhibits Influenza A H1N1 Virus Infection
by Yaping Pei, Zhihua Chen, Ruihan Zhao, Yanxing An, Haiche Yisihaer, Chaojie Wang, Yaning Bai, Libin Liang, Lin Jin and Yongting Hu
Antibiotics 2024, 13(7), 606; https://doi.org/10.3390/antibiotics13070606 - 28 Jun 2024
Viewed by 320
Abstract
Influenza viruses are the leading cause of upper respiratory tract infections, leading to several global pandemics and threats to public health. Due to the continuous mutation of influenza A viruses, there is a constant need for the development of novel antiviral therapeutics. Recently, [...] Read more.
Influenza viruses are the leading cause of upper respiratory tract infections, leading to several global pandemics and threats to public health. Due to the continuous mutation of influenza A viruses, there is a constant need for the development of novel antiviral therapeutics. Recently, natural antimicrobial peptides have provided an opportunity for the discovery of anti-influenza molecules. Here, we designed several peptides based on pheasant cathelicidin and tested their antiviral activities and mechanisms against the H1N1 virus. Of note, the designed peptides Pc-4 and Pc-5 were found to inhibit replication of the H1N1 virus with an IC50 = 8.14 ± 3.94 µM and 2.47 ± 1.95 µM, respectively. In addition, the cyclic peptide Pc-5 was found to induce type I interferons and the expression of interferon-induced genes. An animal study showed that the cyclic peptide Pc-5 effectively inhibited H1N1 virus infection in a mouse model. Taken together, our work reveals a strategy for designing cyclic peptides and provides novel molecules with therapeutic potential against influenza A virus infection. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Bioactive Peptides and Their Derivatives)
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11 pages, 3242 KiB  
Article
Efficacy of Short Novel Antimicrobial Peptides in a Mouse Model of Staphylococcus pseudintermedius Skin Infection
by Mingyu Ouyang, Fangrong Wu and Changmin Hu
Antibiotics 2024, 13(6), 508; https://doi.org/10.3390/antibiotics13060508 - 30 May 2024
Viewed by 605
Abstract
As the clinical application of antibiotics for bacterial skin infections in companion animals becomes increasingly prevalent, the issue of bacterial resistance has become more pronounced. Antimicrobial peptides, as a novel alternative to traditional antibiotics, have garnered widespread attention. In our study, synthetic peptides [...] Read more.
As the clinical application of antibiotics for bacterial skin infections in companion animals becomes increasingly prevalent, the issue of bacterial resistance has become more pronounced. Antimicrobial peptides, as a novel alternative to traditional antibiotics, have garnered widespread attention. In our study, synthetic peptides ADD-A and CBD3-ABU were tested against Staphylococcus pseudintermedius skin infections in KM mice. ADD-A was applied topically and through intraperitoneal injection, compared with control groups and treatments including CBD3-ABU, ampicillin sodium, and saline. Wound contraction, bacterial counts and histology were assessed on days 3 and 11 post-infection. ADD-A and ampicillin treatments significantly outperformed saline in wound healing (p < 0.0001 and p < 0.001, respectively). ADD-A also showed a markedly lower bacterial count than ampicillin (p < 0.0001). Histologically, ADD-A-applied wounds had better epidermal continuity and a thicker epidermis than normal, with restored follicles and sebaceous glands. ADD-A’s effectiveness suggests it as a potential alternative to antibiotics for treating skin infections in animals. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Bioactive Peptides and Their Derivatives)
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