Antimicrobial Agents: Present Situation and Prospects for the Future

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 2950

Special Issue Editor


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Guest Editor
School of Science and Technology, Nottingham Trent University, Nottingham, UK
Interests: biofilms; metallotherapeutic compounds; implant-associated infections; novel antimicrobial agents; reactive oxygen species; reactive nitrogen species; carbon monoxide and CO-releasing molecules

Special Issue Information

Dear Colleagues,

Over recent decades, there has been a significant increase in microbial infections that display multidrug resistance, leading to a concomitant increase in mortality rates. As last-line antimicrobial treatments increasingly fail, antimicrobial resistance is becoming an ever-increasing global threat to public health.

Metal complexes have demonstrated antimicrobial activity throughout recorded history; however, due to the wide range of effective conventional antibiotics developed for use since the early 1940s, these leads are mostly underdeveloped. With the current growing antibiotic resistance crisis and lack of development of new antibiotics, the use of metals as antimicrobials has gained popularity in recent years, raising the possibility that metal complexes can bring new life to antimicrobial drug discovery.

This Special Issue aims to gather papers describing the current use and future development of metal complexes as antimicrobial agents that are active against bacteria, fungi and viruses. We are also welcoming papers describing the discovery of novel targets and mechanisms of action and resistance, as well as the use of omic and bioinformatic approaches for the development of new metal-based antimicrobial leads.

In this Special Issue, original research articles and reviews are welcome.

I look forward to receiving your contributions.

Dr. Samantha McLean
Guest Editor

Manuscript Submission Information

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Keywords

  • metals
  • novel antimicrobials
  • infection
  • drug discovery
  • nanoparticles
  • antimicrobial resistance
  • drug delivery
  • adjuvants
  • synergy

Published Papers (1 paper)

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Research

11 pages, 998 KiB  
Article
Synergistic Antibacterial Potential of 6-Pentyl-α-pyrone Lactone and Zinc Oxide Nanoparticles against Multidrug-Resistant Enterobacterales Isolated from Urinary Tract Infections in Humans
by Ahmed M. E. Kotb, Norhan K. Abd El-Aziz, Eman Y. T. Elariny, Reham Yahya, Dalal Hussien M. Alkhalifah and Rania M. Ahmed
Antibiotics 2022, 11(4), 440; https://doi.org/10.3390/antibiotics11040440 - 24 Mar 2022
Cited by 8 | Viewed by 2488
Abstract
Urinary tract infection (UTI) is one of the most common bacterial infections in the world, which is associated with high morbidity and mortality rates. Enterobacterales species are considered the most causative agent for UTI, especially uropathogenic Escherichia coli (UPEC). Here, we investigated the [...] Read more.
Urinary tract infection (UTI) is one of the most common bacterial infections in the world, which is associated with high morbidity and mortality rates. Enterobacterales species are considered the most causative agent for UTI, especially uropathogenic Escherichia coli (UPEC). Here, we investigated the antibacterial activity of the green fungal metabolite, 6-pentyl α pyrone lactone, alone or in combination with zinc oxide nanoparticles (ZnONPs) against multidrug-resistant Enterobacterales recovered from UTI. The results revealed that 57.27% of human urine samples were positive for Enterobacterales, where E. coli was the most prevalent bacterial pathogen (66.67%). Of note, 98.41% of Enterobacterales isolates were multidrug-resistant (MDR) with multiple antimicrobial resistance (MAR) indices ranged from 0.437 to 1. Fifty percent of the examined isolates were positive for the integrase gene; 60% out of them harbored class 2 integron, whereas the other 40% carried class 1 integrons. The broth microdilution assay ensured that the 6-pentyl-α-pyrone lactone had a reasonable antimicrobial effect against the examined isolates (Minimum inhibitory concentration (MIC) values of 16–32 μg/mL). However, ZnONPs showed a strong antimicrobial effect against the investigated isolates with MIC values ranging from 0.015 to 32 μg/mL. Interestingly, the MICs decreased 5–12 fold and 3–11 fold for 6-pentyl-α-pyrone lactone and ZnONPs, respectively, against examined isolates after their combination. This is the first report suggesting the use of 6-pentyl α pyrone lactone and ZnONPs combination as a promising candidate against MDR Enterobacterales recovered from UTI. Full article
(This article belongs to the Special Issue Antimicrobial Agents: Present Situation and Prospects for the Future)
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