Fungal Metabolites and Synthetic Derivatives: Antimicrobial Properties Toward Microbial Pathogens
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Fungi and Their Metabolites".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 121
Special Issue Editor
Special Issue Information
Dear Colleagues,
The resistance of bacteria to current antibiotics and the limitations in toxicity of antiparasitic and antifungal medications pose significant challenges to global public health. Fungal metabolites and their synthetic derivatives have long been explored as promising alternatives, with notable successes such as penicillins and cephalosporins. Additionally, key antifungal agents (including griseofulvin and echinocandins) originating from fungal sources highlight the importance of these natural products in antimicrobial therapy. Synthetic derivatives of natural products, such as β-lactams, including carbapenems, are crucial in treating resistant bacterial infections. Furthermore, the development of synthetic triazole derivatives has enhanced antifungal therapy, providing broader-spectrum activity and better pharmacokinetic properties. These compounds exemplify the potential of synthetic modifications to enhance efficacy and reduce toxicity.
This Special Issue aims to explore the antimicrobial properties of fungal metabolites and their synthetic derivatives, focusing on innovative approaches to combat microbial pathogens. We invite contributions that delve into the discovery, development, and application of these compounds, as well as their underlying mechanisms of action.
We encourage researchers worldwide to submit original research articles and reviews related to fungal metabolites and synthetic derivatives. Moreover, this Special Issue is proudly edited by João Vicente Braga de Souza, one of the Amazonian researchers dedicated to exploring the unparalleled fungal biodiversity of the Amazon in search of new antimicrobial agents.
Potential themes include the identification of novel fungal metabolites, synthetic modifications of natural products, and case studies of successful antimicrobial applications. Original research and reviews are welcome.
We look forward to your contributions to this Special Issue, which symbolizes a collective effort to discover the next generation of antibiotics.
Prof. Dr. João Vicente Braga De Souza
Guest Editor
Manuscript Submission Information
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Keywords
- antimicrobial resistance
- fungal metabolites
- synthetic derivatives
- antifungal agents
- bioactive compounds
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