Advancements in the Control and Diagnosis of Antimicrobial Resistance in Infectious Diseases

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 868

Special Issue Editors


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Guest Editor
Daejeon & Chungcheong reference Lab., Seegene Medical Foundation, Daejeon 35203, Republic of Korea
Interests: molecular microbiology; antimicrobial resistance; infectious diseases

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Guest Editor
Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain
Interests: antimicrobial resistance; therapeutic drug monitoring; antimicrobial stewardship; vaccines; prosthetic-device-related infections; infective endocarditis; infections in patients with heart diseases and pneumonia

Special Issue Information

Dear Colleagues,

The global increase in antimicrobial and antiviral resistance poses a significant threat to human efforts to combat infectious diseases. The importance of proper stewardship in addressing antimicrobial and antiviral resistance is becoming increasingly evident. Understanding the mechanisms underlying antimicrobial and antiviral resistance, as well as developing advanced laboratory diagnostics for early detection, is crucial for effectively controlling and preventing these resistance phenomena.

For this Special Issue, we invite research contributions addressing the following themes:

  1. Epidemiology of antimicrobial and antiviral resistance;
  2. Viral infection in immunocompromised patients;
  3. Control and prevention of antimicrobial and antiviral resistance;
  4. Strategies of antimicrobial stewardship to combat antimicrobial and antiviral resistance;
  5. Advanced laboratory diagnostics of antimicrobial and antiviral resistance;
  6. Mechanism of antimicrobial resistance antiviral resistance.

Dr. Soyoun Shin
Dr. Alicia Galar
Guest Editors

Manuscript Submission Information

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Keywords

  • infectious diseases
  • antimicrobial resistance
  • laboratory diagnostics

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Published Papers (1 paper)

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Research

12 pages, 282 KiB  
Article
Detection of Chlamydia trachomatis and Neisseria gonorrhoeae (and Its Resistance to Ciprofloxacin): Validation of a Molecular Biology Tool for Rapid Diagnosis and Treatment
by María Paz Peris, Henar Alonso, Cristina Escolar, Alexander Tristancho-Baró, María Pilar Abad, Antonio Rezusta and Ana Milagro
Antibiotics 2024, 13(11), 1011; https://doi.org/10.3390/antibiotics13111011 - 28 Oct 2024
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Abstract
Background and Objectives: Neisseria gonorrhoeae and Chlamydia trachomatis can cause similar clinical syndromes and may coexist in infections. In emergency medicine, empirical treatment targeting both pathogens is often employed, potentially contributing to antibiotic resistance. Gonococcal resistance has emerged against first-line antimicrobials, necessitating [...] Read more.
Background and Objectives: Neisseria gonorrhoeae and Chlamydia trachomatis can cause similar clinical syndromes and may coexist in infections. In emergency medicine, empirical treatment targeting both pathogens is often employed, potentially contributing to antibiotic resistance. Gonococcal resistance has emerged against first-line antimicrobials, necessitating prior testing for fluoroquinolone susceptibility. Certest Biotec developed two molecular diagnostic products for simultaneous detection: VIASURE C. trachomatis & N. gonorrhoeae Real-Time PCR Detection Kit and VIASURE Neisseria gonorrhoeae Ciprofloxacin-Resistant Real-Time PCR Detection Kit. To evaluate these products, clinical performance assessments were conducted at the Clinical Microbiology Laboratory of Miguel Servet University Hospital in Zaragoza, Spain. Results and Conclusions: Both VIASURE assays under study demonstrated high clinical sensitivity and specificity compared to reference molecular assays and Sanger sequencing. These kits offer an accurate diagnosis, facilitating appropriate treatment choices while addressing concerns about emerging antibiotic resistance. Methods: A total of 540 clinical samples from 540 patients already characterized as positive or negative for CT and NG by a molecular assay and by antibiotic susceptibility testing for ciprofloxacin using a concentration gradient diffusion method were used for the clinical evaluation. In cases where sensitivity results were unavailable, conventional PCR and Sanger sequencing were employed. Full article
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