Challenges and Emerging Strategies to Tackle the Global Burden of Antimicrobial Resistance

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 633

Special Issue Editor


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Guest Editor
1. University Centre Varaždin, University North, Varazdin, Croatia
2. Institute for Health Metrics and Evaluation (IHME), University of Washington, Seatle, WA, USA
3. Department of Health Metrics Sciences, University of Washington School of Medicine, Seattle, WA, USA
Interests: global burden of AMR; AMR surveillance; diagnostics; treatment; multi-resistant microorganisms; AMR policy; antibiotic stewardship; public health; global health
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Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) poses a significant global health threat, with far-reaching implications for health systems and society. Despite the immense disease burden due to resistant microorganisms and urgent need for effective strategies to tackle them, there remains a clear lack of practical clinical research to inform much-needed advances in this field. The emergence of multidrug-resistant pathogens compromises the effectiveness of standard antibiotic treatment regimens, jeopardising in turn medical progress and patient outcomes worldwide.

Therefore, prompt and effective action is essential to address the challenges posed by AMR and develop strategies to mitigate its impact. This Special Issue of the journal "Antibiotics" aims to address this critical issue by focusing on articles covering a range of topics related to AMR. These include novel approaches to AMR diagnostics, surveillance strategies and antimicrobial treatment strategies, but also cover novel approaches to antibiotic stewardship and local/global policy perspectives.

I am pleased to invite submissions of high-quality research-based or review papers addressing the challenges and emerging strategies to tackle the global burden of antimicrobial resistance. The end-goal is to create a timely and highly relevant collection of articles aimed at addressing this pressing topic, which is currently one of the biggest global health concerns the humanity has faced.

Dr. Tomislav Meštrović
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance (AMR)
  • global burden of AMR
  • AMR in the context of public and global health
  • diagnostic and treatment of AMR
  • new approaches to AMR surveillance
  • antibiotic stewardship
  • local and global policy initiatives on AMR
  • prevention of AMR

Published Papers (1 paper)

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Research

8 pages, 770 KiB  
Article
Ciprofloxacin Concentrations 100-Fold Lower than the MIC Can Select for Ciprofloxacin Resistance in Neisseria subflava: An In Vitro Study
by Zina Gestels, Saïd Abdellati, Chris Kenyon and Sheeba Santhini Manoharan-Basil
Antibiotics 2024, 13(6), 560; https://doi.org/10.3390/antibiotics13060560 - 14 Jun 2024
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Abstract
Neisseria gonorrhoeae can acquire antimicrobial resistance (AMR) through horizontal gene transfer (HGT) from other Neisseria spp. such as commensals like Neisseria subflava. Low doses of antimicrobials in food could select for AMR in N. subflava, which could then be transferred to N. [...] Read more.
Neisseria gonorrhoeae can acquire antimicrobial resistance (AMR) through horizontal gene transfer (HGT) from other Neisseria spp. such as commensals like Neisseria subflava. Low doses of antimicrobials in food could select for AMR in N. subflava, which could then be transferred to N. gonorrhoeae. In this study, we aimed to determine the lowest concentration of ciprofloxacin that can induce ciprofloxacin resistance (minimum selection concentration—MSC) in a N. subflava isolate (ID-Co000790/2, a clinical isolate collected from a previous community study conducted at ITM). In this study, Neisseria subflava was serially passaged on gonococcal (GC) medium agar plates containing ciprofloxacin concentrations ranging from 1:100 to 1:10,000 below its ciprofloxacin MIC (0.006 µg/mL) for 6 days. After 6 days of serial passaging at ciprofloxacin concentrations of 1/100th of the MIC, 24 colonies emerged on the plate containing 0.06 µg/mL ciprofloxacin, which corresponds to the EUCAST breakpoint for N. gonorrhoeae. Their ciprofloxacin MICs were between 0.19 to 0.25 µg/mL, and whole genome sequencing revealed a missense mutation T91I in the gyrA gene, which has previously been found to cause reduced susceptibility to fluoroquinolones. The N. subflava MSCde novo was determined to be 0.06 ng/mL (0.00006 µg/mL), which is 100×-fold lower than the ciprofloxacin MIC. The implications of this finding are that the low concentrations of fluoroquinolones found in certain environmental samples, such as soil, river water, and even the food we eat, may be able to select for ciprofloxacin resistance in N. subflava. Full article
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