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Antibiotics
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Antibacterial Resistance and Novel Strategies to Eradicate Bacterial Biofilms, 2nd...
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Antibacterial Resistance and Novel Strategies to Eradicate Bacterial Biofilms, 2nd Volume

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiofilm Strategies".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 4139

Special Issue Editor

Dr. Theerthankar Das

E-Mail Website
Guest Editor
Infection Immunity and Inflammation theme, Sydney Institute for Infectious Diseases, Charles Perkins Centre, School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia
Interests: bacterial biofilm; quorum sensing in bacteria; antimicrobial drug development; host-pathogen interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first volume of the Special Issue, titled "Antibacterial Resistance and Novel Strategies to Eradicate Bacterial Biofilms", was published in 2022 and was successful in generating high-quality original research and review articles. The research topic bacterial biofilms and antimicrobial resistance always receives considerable attention, with a specific focus on the development of new antibacterial agents.

In this second volume, we aim to complement the 2022 Special Issue and welcome submissions that address the current advances in biofilm biology, bacteriology, and antimicrobial resistance mechanism, as well as new strategies on the development of antibacterial agents.

Topics may include, but are not limited to, the following:

  • Factors affecting bacterial biofilm formation;
  • The role of quorum sensing in bacterial biofilm formation, virulence factor production, and antimicrobial resistance;
  • Host–pathogen interactions;
  • Antimicrobial combination therapy to eradicate biofilms;
  • Combination therapy vs. monotherapy against multidrug resistance bacteria;
  • Mixed species biofilm including fungal biofilms;
  • Food bacterial pathogens;
  • Epidemiology studies on bacterial infections and challenges in developed vs developing countries;
  • The use and misuse of antibacterial agents and the rise of superbugs;
  • Challenges in developing antimicrobial surfaces for biomedical applications;
  • Antimicrobial resistance in animal health;
  • Biofilm matrix and functions of bacterial polymers, including extracellular DNA, polysaccharides, proteins, and amyloids.

Dr. Theerthankar Das
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacterial biofilms
  • quorum sensing
  • antimicrobial resistance
  • superbugs
  • biofilm matrix
  • virulence factors
  • host-pathogen interactions
  • antibacterial surfaces

Published Papers (2 papers)

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Research

14 pages, 2560 KiB  
Article
Anti-Staphylococcal Biofilm Effects of a Liposome-Based Formulation Containing Citrus Polyphenols
by Diletta Mazzantini, Mariacristina Massimino, Marco Calvigioni, Virginia Rossi, Francesco Celandroni, Antonella Lupetti, Giovanna Batoni and Emilia Ghelardi
Antibiotics 2024, 13(4), 318; https://doi.org/10.3390/antibiotics13040318 - 30 Mar 2024
Cited by 2 | Viewed by 1358
Abstract
Biofilms are surface-associated microbial communities embedded in a matrix that is almost impenetrable to antibiotics, thus constituting a critical health threat. Biofilm formation on the cornea or ocular devices can lead to serious and difficult-to-treat infections. Nowadays, natural molecules with antimicrobial activity and [...] Read more.
Biofilms are surface-associated microbial communities embedded in a matrix that is almost impenetrable to antibiotics, thus constituting a critical health threat. Biofilm formation on the cornea or ocular devices can lead to serious and difficult-to-treat infections. Nowadays, natural molecules with antimicrobial activity and liposome-based delivery systems are proposed as anti-biofilm candidates. In this study, the anti-biofilm activity of a formulation containing citrus polyphenols encapsulated in liposomes was evaluated against Staphylococcus aureus and Staphylococcus epidermidis, the most common agents in ocular infections. The formulation activity against planktonic staphylococci was tested by broth microdilution and sub-inhibitory concentrations were used to evaluate the effect on biofilm formation using the crystal violet (CV) assay. The eradicating effect of the preparation on mature biofilms was investigated by the CV assay, plate count, and confocal laser scanning microscopy. The product was bactericidal against staphylococci at a dilution of 1:2 or 1:4 and able to reduce biofilm formation even if diluted at 1:64. The formulation also had the ability to reduce the biomass of mature biofilms without affecting the number of cells, suggesting activity on the extracellular matrix. Overall, our results support the application of the used liposome-encapsulated polyphenols as an anti-biofilm strategy to counter biofilm-associated ocular infections. Full article
(This article belongs to the Special Issue Antibacterial Resistance and Novel Strategies to Eradicate Bacterial Biofilms, 2nd Volume)
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13 pages, 2930 KiB  
Article
Investigating the Role of Antibiotics on Induction, Inhibition and Eradication of Biofilms of Poultry Associated Escherichia coli Isolated from Retail Chicken Meat
by Aisha Noreen, Hamid Masood, Jaweria Zaib, Zara Rafaque, Areeta Fatima, Hira Shabbir, Javaria Alam, Aisha Habib, Saba Noor, Kinza Dil and Javid Iqbal Dasti
Antibiotics 2022, 11(11), 1663; https://doi.org/10.3390/antibiotics11111663 - 19 Nov 2022
Cited by 1 | Viewed by 2372
Abstract
Background: Widespread use of antibiotics as growth promoters and prophylactic agents has dramatic consequences for the development of antibiotic resistance. In this study, we investigated effects of selected antibiotics on bacterial biofilms and performed extensive antibiotic and VF profiling of poultry-meat associated E. [...] Read more.
Background: Widespread use of antibiotics as growth promoters and prophylactic agents has dramatic consequences for the development of antibiotic resistance. In this study, we investigated effects of selected antibiotics on bacterial biofilms and performed extensive antibiotic and VF profiling of poultry-meat associated E. coli strains. Methods: Antibiotic susceptibility was performed by a disc diffusion method, followed by molecular screening of resistance and virulence determinants. Further biofilm formation assays, MIC-p, MIC-b, MBIC and MBEC, were performed using standard tissue culture plate method. Results: In total, 83 (75%) samples were confirmed as E. coli from poultry sources, 26 different antibiotics were tested, and maximum numbers of the isolates were resistant to lincomycin (100%), while the least resistance was seen against cefotaxime (1%) and polymyxin B (1%). Overall, 48% of the isolates were ESBL producers and 40% showed carbapenemase activity; important virulence genes were detected in following percentages: fimH32 (39%), papC21 (25%), iutA34 (41%), kpsMT-II23 (28%), papEF9 (11%), papGII22 (27%) and fyuA13 (16%). Colistin showed remarkable anti-biofilm activity, while at sub-MIC levels, gentamicin, ceftriaxone and enrofloxin significantly (p < 0.01) inhibited the biofilms. A strong induction of bacterial biofilm, after exposure to sub-minimal levels of colistin clearly indicates risk of bacterial overgrowth in a farm environment, while use of colistin aggravates the risk of emergence of colistin resistant Enterobacteriaceae, a highly undesirable public health scenario. Full article
(This article belongs to the Special Issue Antibacterial Resistance and Novel Strategies to Eradicate Bacterial Biofilms, 2nd Volume)
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