Bacteriophages and Other Alternative Antimicrobials to Combat Multidrug Resistance
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Bacteriophages".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 12007
Special Issue Editors
Interests: bacteriophage biology and bacteriophage therapy
Interests: bacteriophage molecular biology and bacteriophage therapy
Special Issue Information
Dear Colleagues,
The global spread of antibiotic resistance in pathogenic bacteria has become an accelerating public health disaster that calls for the development of novel therapeutic approaches. These new antibacterial agents include bacteriophages, small molecule antibiotics, monoclonal antibodies, antivirulence drugs, antimicrobial peptides, bacteriocins, and predatory bacteria. Some of these novel drugs have shown significant efficacy in laboratory animals and in humans. There are publications that describe multiple positive outcomes in patients with different severe multidrug-resistant infections by compassionate use as well as some successful clinical trials for evaluating new antibacterials. However, much work remains!
This Special Issue is focused on isolation, synthesis, engineering, characterization, preclinical testing and clinical use of any novel antibacterials that are alternatives to classical antibiotics. Articles covering comparisons and combinations of new drugs and standard-of-care antibiotics are also welcome. Additional topics of interest will include safety, stability and immunogenicity of novel drugs, improved formulations, manufacturing, storage, delivery, regulatory aspects, and the development of bacterial resistance and ways to overcome it. Both original papers and review articles will be considered for publication in this Special Issue of Antibiotics.
Dr. Andrey A. Filippov
Dr. Mikeljon P. Nikolich
Guest Editors
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Keywords
- multidrug resistance
- alternative antibacterials
- bacteriophage therapy
- phage-antibiotic synergy
- phage lysins
- small molecule drugs
- monoclonal antibodies
- antivirulence drugs
- pharmacokinetics and pharmacodynamics
- resistance to novel drugs
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