Biofilm Infection
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (31 October 2015) | Viewed by 55926
Special Issue Editors
Interests: Candida biofilms; antibiofilm; microbiome
Special Issues, Collections and Topics in MDPI journals
Interests: the role of biofilms in human infection; treatment of infection in immunocompromised patients; the role of the built environment in the transmission of healthcare associated infection
Special Issue Information
Dear Colleagues,
In clinical microbiology when chemotherapeutic management fails, there is a tendency to focus on defined antimicrobial resistance mechanisms related to inheritable genetic traits. However, it is increasingly apparent that treatment failure may be related to microbial biofilms, which are an increasingly important clinical problem. Microbial biofilms are complex and heterogeneous structures encased within extrapolymeric matrix, and cells encased within, exhibit dramatic change in their resistance profiles compared to free-floating counterparts by adapting to their environment and changing their phenotypic and genotypic characteristics accordingly.
While our understanding of the basic biology of microbial biofilms has greatly improved, we still face challenges in developing effective clinical management strategies. Some key areas still require exploration:
- How do we diagnose biofilm related infections more effectively?
- What is the impact of biofilms on clinical outcomes?
- How do we manage polymicrobial biofilm infection?
- Are there methods to augment existing chemotherapeutic strategies?
- Does sub-optimal treatment of biofilms make them more pathogenic?
"Antibiotics" will publish a special issue focusing on the clinical management of biofilm related infections. It is our pleasure to invite submissions of high quality research based papers related to the questions mentioned above.
Prof. Dr. Gordon Ramage
Prof. Dr. Craig Williams
Dr. Karen Smith
Guest Editors
Manuscript Submission Information
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