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Antibiotics
Special Issues
Antimicrobial Lipids from Plants and Marine Organisms
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Antimicrobial Lipids from Plants and Marine Organisms

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (30 April 2020) | Viewed by 11460

Special Issue Editors

Dr. Eliana Alves

E-Mail Website
Guest Editor
Department of Chemistry & LAQV-REQUIMTE, University of Aveiro, Campus Universitario de Santiago, 3810-193 Aveiro, Portugal
Interests: lipidomics; mass spectrometry; bioactive lipids; polar lipids; plant lipids; fruit seeds; olives; olive oil; nutrition; food lipidomics; Mediterranean diet
Special Issues, Collections and Topics in MDPI journals
Dr. Felisa Rey

E-Mail Website
Guest Editor
1. CESAM and Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal
2. Mass Spectrometry Centre & LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal
Interests: lipidomics; fatty acids; bioactive compounds; mass spectrometry, marine biotechnology, marine fungi
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plants and marine organisms are extraordinary reservoirs of natural products with biological activity. In order to combat the remarkable increase in antibiotic resistance, it is necessary to find novel antimicrobials from natural sources that have intrinsic defense strategies. Lipids include a myriad of structures and the ability to adapt to environmental changes and protect plants and marine organisms from different environmental stresses. Several lipid classes obtained from these matrices have antimicrobial activity on different human pathogens. Free fatty acids have been the most studied compounds. However, the great world of lipids as antimicrobials is far from being fully explored. Thus, it is imperative to explore these endless sources of bioactive lipids, and to isolate, identify and characterize the compounds that exert the antimicrobial activity and to evaluate their in vitro and in vivo efficiency.

We kindly invite you to contribute with exciting and new research papers or state-of-the-art reviews on the antimicrobial activity of lipids from plant and/or marine origin. This issue aims at gathering the most recent work from researchers keen to demonstrate that lipids from natural sources are promising candidates as antibiotics and to boost new biotechnological applications of lipids in medicine, and in nutraceutical and pharmaceutical industries.

Dr. Eliana Alves
Dr. Felisa Rey
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibacterial
  • antifungal
  • antimicrobial activity
  • antimicrobial compound
  • antiparasitic
  • lipidomics
  • marine lipids
  • natural product
  • plant lipids
  • secondary metabolism

Published Papers (2 papers)

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Research

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18 pages, 3345 KiB  
Article
Design and Characterization of Bioactive Bilayer Films: Release Kinetics of Isopropyl Palmitate
by Ângelo Luís, Eugenia Gallardo, Ana Ramos and Fernanda Domingues
Antibiotics 2020, 9(8), 443; https://doi.org/10.3390/antibiotics9080443 - 24 Jul 2020
Cited by 11 | Viewed by 3324
Abstract
Active packaging incorporating antioxidants and antimicrobials is creating a niche in the market and becoming increasingly important. The main goal of this work was the design of bioactive bilayer films (zein/pullulan) incorporating licorice essential oil. The bilayer films were fully characterized in terms [...] Read more.
Active packaging incorporating antioxidants and antimicrobials is creating a niche in the market and becoming increasingly important. The main goal of this work was the design of bioactive bilayer films (zein/pullulan) incorporating licorice essential oil. The bilayer films were fully characterized in terms of their chemical, physical, barrier, antioxidant, and antimicrobial properties. Furthermore, the release kinetics of isopropyl palmitate, the major compound of the licorice essential oil, was evaluated by HPLC-DAD (high-performance liquid chromatography coupled to diode-array detector). Scanning Electron Microscopy (SEM) micrographs of cross-sections of the bilayer films clearly show the two layers of the films. Besides presenting the capacity to scavenge free radicals and to inhibit the lipid peroxidation, the developed bilayer films were also able to inhibit the growth of known foodborne pathogens (Enterococcus faecalis and Listeria monocytogenes). The release kinetics profile of isopropyl palmitate from bilayer films incorporating licorice essential oil demonstrated that in 50% ethanol at room temperature, the release was more effective, suggesting that the bilayer films will be more efficient if applied to package semi-fatty food. Full article
(This article belongs to the Special Issue Antimicrobial Lipids from Plants and Marine Organisms)
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Review

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88 pages, 1935 KiB  
Review
Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects
by Eliana Alves, Marina Dias, Diana Lopes, Adelaide Almeida, Maria do Rosário Domingues and Felisa Rey
Antibiotics 2020, 9(8), 441; https://doi.org/10.3390/antibiotics9080441 - 24 Jul 2020
Cited by 38 | Viewed by 7514
Abstract
In the actual post-antibiotic era, novel ways of rethinking antimicrobial research approaches are more urgent than ever. Natural compounds with antimicrobial activity such as fatty acids and monoacylglycerols have been investigated for decades. Additionally, the interest in other lipid classes as antimicrobial agents [...] Read more.
In the actual post-antibiotic era, novel ways of rethinking antimicrobial research approaches are more urgent than ever. Natural compounds with antimicrobial activity such as fatty acids and monoacylglycerols have been investigated for decades. Additionally, the interest in other lipid classes as antimicrobial agents is rising. This review provides an overview on the research about plant and marine lipids with potential antimicrobial activity, the methods for obtaining and analyzing these compounds, with emphasis on lipidomics, and future perspectives for bioprospection and applications for antimicrobial lipids. Lipid extracts or lipids isolated from higher plants, algae or marine invertebrates are promising molecules to inactivate a wide spectrum of microorganisms. These lipids include a variety of chemical structures. Present and future challenges in the research of antimicrobial lipids from natural origin are related to the investment and optimization of the analytical workflow based on lipidomics tools, complementary to the bioassay-guided fractionation, to identify the active compound(s). Also, further work is needed regarding the study of their mechanism of action, the structure–activity relationship, the synergistic effect with conventional antibiotics, and the eventual development of resistance to lipids, which, as far as is known, is unlikely. Full article
(This article belongs to the Special Issue Antimicrobial Lipids from Plants and Marine Organisms)
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