Antimicrobial Mechanism and Enlightenment to New Antimicrobial Agents

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanisms and Structural Biology of Antibiotic Action".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 1672

Special Issue Editors


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Guest Editor
CAS Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
Interests: antimicrobial resistance; anti-virulence therapy; natural products with antibacterial activity; Gram-negative microbe; ESKAPE pathogens; diagnosis

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Guest Editor
Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, USA
Interests: bacteriophage; endolysin; peptidoglycan hydrolase; protein engineering; directed evolution; natural products

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Guest Editor
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
Interests: immune responses to phages and phage proteins; protein engineering; pharmacokinetics; in vivo models

Special Issue Information

Dear Colleagues,

The increased emergence of antimicrobial resistance (AMR) is a major healthcare problem worldwide. AMR is one of the outcomes of long-term interaction of microorganisms with their living environments. Understanding the mechanisms and drivers of AMR will provide a scientific basis and strategy to combat the threat to human health and biosecurity from AMR. In addition, AMR necessitates the development of novel antimicrobial agents with different mechanisms of action from traditional antibiotics. These alternatives include natural products (e.g., flavonoids, phytochemicals, and polysaccharides), phage and phage-derived endolysins, vaccines, probiotics, antibodies, peptides, and other solutions.

The aim of this Special Issue is to present the status of and future trends in tracking antimicrobial mechanism and the enlightenment for new antimicrobial agents. This Special Issue collects manuscripts that improve our understanding of AMR and the development of new antimicrobial agents. Manuscripts about antimicrobial mechanisms, the discovery of novel antimicrobial agents (including but not limited to natural products, polysaccharides, phage and phage lysin, vaccines, probiotics, antibodies, peptides, and proteins), new methods for AMR surveillance, diagnosis, and antimicrobial screening, experimental therapy of antimicrobial agents in vitro and in vivo, and the antibacterial, antibiofilm, and antifungal applications of these agents in the related field of microbiology, biotechnology, and pharmacology are welcome for submission.

Prof. Dr. Hang Yang
Prof. Dr. Daniel C. Nelson
Prof. Dr. Krystyna Dąbrowska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • antimicrobial agents
  • natural products
  • nontraditional antibiotics
  • experimental therapy
  • antibiofilm
  • diagnosis
  • mechanisms of action

Published Papers (1 paper)

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7 pages, 559 KiB  
Perspective
Macromolecular Structure Assembly as a Novel Antibiotic Target
by Scott Champney
Antibiotics 2022, 11(7), 937; https://doi.org/10.3390/antibiotics11070937 - 13 Jul 2022
Viewed by 1381
Abstract
This review discusses the inhibition of macromolecular structure formation as a novel and under-investigated drug target. The disruption of cell wall structures by penicillin-binding protein interactions is one potential target. Inhibition of DNA polymerase III assembly by novel drugs is a second target [...] Read more.
This review discusses the inhibition of macromolecular structure formation as a novel and under-investigated drug target. The disruption of cell wall structures by penicillin-binding protein interactions is one potential target. Inhibition of DNA polymerase III assembly by novel drugs is a second target that should be investigated. RNA polymerase protein structural interactions are a third potential target. Finally, disruption of ribosomal subunit biogenesis represents a fourth important target that can be further investigated. Methods to examine these possibilities are discussed. Full article
(This article belongs to the Special Issue Antimicrobial Mechanism and Enlightenment to New Antimicrobial Agents)
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