Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.3
4.3
Journals
Antibiotics
Special Issues
Anti-infectious Drugs in Ophthalmology
share announcement

Anti-infectious Drugs in Ophthalmology

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: closed (15 October 2022) | Viewed by 7716

Special Issue Editor

Prof. Dr. Kaili Wu

E-Mail Website
Guest Editor
Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510060, China
Interests: ophthalmology; ocular surface diseases; infecitious disease; virus; bacteria; tear; proteome

Special Issue Information

Dear Colleagues,

The treatment of ocular infections is essential to prevent blindness and to increase the quality of life for patients worldwide. In ophthalmology, anti-microbial agents are unique in terms of their drug formulation, dosage forms, methods of administration, pharmacokinetics and pharmacodynamics, as well as their coverage for microorganism spectra of eye infections. In the recent years, a great number of studies continue to enhance our understanding of the clinical application of ocular antibacterial agents, the epidemiology of antimicrobial-resistances/susceptibility, the development of novel antimicrobials and the investigation of ocular infectious disease. Summarizing and updating the knowledge on antimicrobial agents and their use in diseases with specific clinical characteristics could play a potentially powerful role on the clinical and basic development of ocular infectious disease.

This special issue is dedicated to integrating our current understanding of new developments in the field of ocular anti-infectious agents, including human and veterinary applications of antimicrobial agents, epidemiological data, clinical trials, novel agents/devices and therapeutics, antimicrobial susceptibility testing methods. Manuscripts concerning all basic and clinical research on antimicrobials, antibacterials, antiviral, antifungal, and antiparasitic agents in ophthalmology are welcome. 

Prof. Dr. Kaili Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobials/ antibactics
  • antimicrobial susceptibility
  • multi-drug resistance
  • antimicrobial device (contact lenses, plugs, sustained-release pellets)
  • clinical trials
  • epidemiological studies
  • ocular pathogenic microbes (bacteria, fungi, virus)
  • animal and cell-based models

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

9 pages, 863 KiB  
Article
Ophthalmic Antimicrobial Prescribing in Australian Healthcare Facilities
by Xin Fang, Noleen Bennett, Courtney Ierano, Rodney James and Karin Thursky
Antibiotics 2022, 11(5), 647; https://doi.org/10.3390/antibiotics11050647 - 12 May 2022
Viewed by 1921
Abstract
The National Antimicrobial Prescribing Survey (NAPS) is a web-based, standardized tool, widely adopted in Australian healthcare facilities to assess the reasons for, the quantity of, and the quality of antimicrobial prescribing. It consists of multiple modules tailored towards the needs of a variety [...] Read more.
The National Antimicrobial Prescribing Survey (NAPS) is a web-based, standardized tool, widely adopted in Australian healthcare facilities to assess the reasons for, the quantity of, and the quality of antimicrobial prescribing. It consists of multiple modules tailored towards the needs of a variety of healthcare facilities. Data regarding ophthalmological antimicrobial use from Hospital NAPS, Surgical NAPS, and Aged Care NAPS were analysed. In Hospital NAPS, the most common reasons for inappropriate prescribing were incorrect dose or frequency and incorrect duration. Prolonged duration was also common in Aged Care prescribing: about one quarter of all antimicrobials had been prescribed for greater than 6 months. All three modules found chloramphenicol to be the most prescribed antimicrobial with a high rate of inappropriate prescribing, usually for conjunctivitis. Full article
(This article belongs to the Special Issue Anti-infectious Drugs in Ophthalmology)
►▼ Show Figures

Figure 1

10 pages, 1371 KiB  
Article
Comparative Study of Ocular Pharmacokinetics of Topical 0.3% Gatifloxacin Eye Gel and Solution in Rabbits
by Manli Liu, Xin Zhao, Yao Yang, Qiang Yang, Jieting Zeng, Yujie Li, Xiaofeng Lin and Fang Duan
Antibiotics 2022, 11(4), 502; https://doi.org/10.3390/antibiotics11040502 - 10 Apr 2022
Viewed by 1935
Abstract
Few articles have reported drug concentrations of different ophthalmic dosage forms in the ocular tissues. This study aimed to determine the ocular pharmacokinetics of gatifloxacin 0.3% eye gel (GTX-Gel) and gatifloxacin 0.3% eye solution (GTX-Sol) at different time intervals after topical instillation in [...] Read more.
Few articles have reported drug concentrations of different ophthalmic dosage forms in the ocular tissues. This study aimed to determine the ocular pharmacokinetics of gatifloxacin 0.3% eye gel (GTX-Gel) and gatifloxacin 0.3% eye solution (GTX-Sol) at different time intervals after topical instillation in rabbits. A total of 126 healthy New Zealand rabbits were included, of which six rabbits did not receive antibiotics (control group). The remaining rabbits were randomly divided into four groups. GTX-Gel and GTX-Sol (50 μL) were topically instilled every hour in groups A1 and B1, respectively, and every two hours in groups A2 and B2, respectively, for 12 h. Ocular tissues were collected 2, 4, 8, 12, and 24 h after administration. Gatifloxacin concentration was measured using high-performance liquid chromatography coupled with tandem mass spectrometry. The drug reached peak concentrations (Cmax) in all tissues at 8–12 h. With the same administration frequency, the Cmax was higher with GTX-Gel than with GTX-Sol (p < 0.05). Except for the iris-ciliary body, other ocular tissues did not show significant difference (p > 0.05) in gatifloxacin concentration between either pair of groups. Gatifloxacin ophthalmic gel was found to attain significantly higher concentrations than the ophthalmic solution in ocular tissues. Full article
(This article belongs to the Special Issue Anti-infectious Drugs in Ophthalmology)
►▼ Show Figures

Figure 1

16 pages, 2240 KiB  
Article
Pathogens and Antibiotic Susceptibilities of Global Bacterial Keratitis: A Meta-Analysis
by Zijun Zhang, Kai Cao, Jiamin Liu, Zhenyu Wei, Xizhan Xu and Qingfeng Liang
Antibiotics 2022, 11(2), 238; https://doi.org/10.3390/antibiotics11020238 - 12 Feb 2022
Cited by 16 | Viewed by 2854
Abstract
Bacterial keratitis (BK) is the most common type of infectious keratitis. The spectrum of pathogenic bacteria and their susceptibility to antibiotics varied with the different regions. A meta-analysis was conducted to review the global culture rate, distribution, current trends, and drug susceptibility of [...] Read more.
Bacterial keratitis (BK) is the most common type of infectious keratitis. The spectrum of pathogenic bacteria and their susceptibility to antibiotics varied with the different regions. A meta-analysis was conducted to review the global culture rate, distribution, current trends, and drug susceptibility of isolates from BK over the past 20 years (2000–2020). Four databases were searched, and published date was limited between 2000 and 2020. Main key words were “bacterial keratitis”, “culture results” and “drug resistance”. Forty-two studies from twenty-one countries (35 cities) were included for meta-analysis. The overall positive culture rate was 47% (95%CI, 42–52%). Gram-positive cocci were the major type of bacteria (62%), followed by Gram-negative bacilli (30%), Gram-positive bacilli (5%), and Gram-negative cocci (5%). Staphylococcus spp. (41.4%), Pseudomonas spp. (17.0%), Streptococcus spp. (13.1%), Corynebacterium spp. (6.6%) and Moraxella spp. (4.1%) were the most common bacterial organism. The antibiotic resistance pattern analysis revealed that most Gram-positive cocci were susceptive to aminoglycoside (86%), followed by fluoroquinolone (81%) and cephalosporin (79%). Gram-negative bacilli were most sensitive to cephalosporin (96%) and fluoroquinolones (96%), followed by aminoglycoside (92%). In Gram-positive cocci, the susceptibility trends of fluoroquinolones were decreasing since 2010. Clinics should pay attention to the changing trends of pathogen distribution and their drug resistance pattern and should diagnose and choose sensitive antibiotics based on local data. Full article
(This article belongs to the Special Issue Anti-infectious Drugs in Ophthalmology)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop