Targeting Inflammation in Animals with Natural Bioactives
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 7073
Special Issue Editor
Interests: animal nutrition and health; immunometabolism; gut microbial metabolism; gut–liver axis; bile acids; plant and microbial bioactives; Drosophila melanogaster
Special Issue Information
It has long been recognized that the inflammatory response triggered by infectious agents impairs animal performance via numerous mechanisms that invariably converge to restrict the availability of nutrients for productive purposes. More recently, it has become evident that infection-independent inflammation, sometimes referred as sterile inflammation, also contributes to deteriorate productivity (health) and welfare in modern settings of animal production. A few examples of this hurdle, for which compelling evidence exists, include gastrointestinal disorders caused by early-life adversity such as weaning stress, diet-induced gut dysbiosis as observed in cases of ruminal and/or intestinal acidosis, metabolic disorders associated with parturition or liver disease, and gut barrier failure caused by heat stress. Certainly, many more challenges confronted by farm animals have the potential to induce sterile inflammation. A frequently observed feature of such inflammatory episodes is the inability of the host to successfully contain or remove the insult, leading to inflammation remaining unresolved for prolonged periods (i.e., chronic inflammation). Irrespective of the origin and form of presentation (acute or chronic), the nutritional deficit and decline in productivity associated with the inflammatory state cannot be fully compensated by increasing the supply of nutrients to the affected animal. These circumstances, coupled with a global trend to “demedicate” animal production, have fueled research to uncover non-pharmacological approaches for protecting farm animals against such a nutrient-draining response. This Special Issue seeks submissions regarding “natural” opportunities for targeting inflammation both directly (therapeutic approach) or indirectly (prevention approach) with bioactive compounds derived from plants, algae, or beneficial microbes. Therefore, the scope of this call includes research on plant and algal compounds, prebiotics, probiotics, and nutritional interventions acting upon the metabolic response of gut microbiota (e.g., microbial metabolome). Submissions on biomarkers of inflammation suitable for monitoring and/or assessing the use of such natural strategies at the farm levels are also encouraged.
Dr. Ignacio Ipharraguerre
Guest Editor
Manuscript Submission Information
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Keywords
- Inflammation
- immunometabolism
- phytochemicals
- algae
- prebiotics
- probiotics
- gut microbial metabolites
- animal production
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