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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antibiotic Resistance and Virulence in Bacterial Isolates: A Genomic Perspective from Human and Animal Sources

edited by

Sónia Ramos

and

Alexandra Nunes

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1764 | Submission Open

Keywords: MDRB; antimicrobial resistance; one health; mobile genetic elements; AMR; antimicrobial resistance gene

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Advancing and Standardising Antimicrobial Susceptibility and Resistance Detection Methodology

edited by

Owen B. Spiller

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1413 | Submission Open

Keywords: antimicrobial susceptibility testing; resistance screening; rapid diagnostics; clinical; veterinary; environmental; validation

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Drivers of Virulence and Antimicrobial Resistance in Emerging and Re-Emerging Pathogens

edited by

Ons Bouchami

Opeyemi Lawal

and Ingrid Maria Cecilia Rubin

submission deadline 31 Mar 2026 | Viewed by 268 | Submission Open

Keywords: AMR; microbial pathogenesis; microbial ecology; pathogen dynamics; genomic epidemiology; multiomics; microbial interactions; AI/ML

(This special issue belongs to the Section Genetic and Biochemical Studies of Antibiotic Activity and Resistance)

Global Partnerships in Response to Antimicrobial Resistance: From Policy to Practice

edited by

Helena Rosado

submission deadline 31 Mar 2026 | Viewed by 244 | Submission Open

Keywords: antimicrobial resistance; antimicrobial stewardship; global health partnerships; collaboration; low- and middle-income countries; health systems strengthening; actionable implementation; AMR interventions

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

New Inhibitors for Overcoming Antimicrobial Resistance

edited by

Humberto Medeiros Barreto

and

Sofia Santos Costa

submission deadline 31 Mar 2026 | Viewed by 233 | Submission Open

Keywords: antimicrobial resistance; resistance mechanisms; inhibitors; enzymatic inhibitors; efflux; biofilms

Current Challenges in Antimicrobial Stewardship

edited by

Andreas A. Von Ameln-Mayerhofer

submission deadline 31 Mar 2026 | Viewed by 230 | Submission Open

Keywords: antimicrobial stewardship; antimicrobial resistance; antibiotics prescribing; intervention; irrational prescriptions; surveillance; therapeutic monitoring; ABS; AMS; antibiotic stewardship; best practice; interprofessional; rational prescribing; DDD/100; RDD/100

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Interdisciplinary Applications of Micro- and Nano-Antimicrobials

edited by Cleonice Gonçalves da Rosa and Michael Ramos Nunes

submission deadline 31 Mar 2026 | Viewed by 227 | Submission Open

Keywords: micro- and nano-antimicrobials; antimicrobial coatings; nanotechnology in medicine; food safety and packaging; agricultural applications; antibiotic resistance; environmental remediation; controlled release systems; pathogen management; antimicrobial materials

(This special issue belongs to the Section Novel Antimicrobial Agents)

Surveillance and Detection of Antimicrobial Resistance: Tools and Trends

edited by

Hung-Sheng Shang

submission deadline 31 Mar 2026 | Viewed by 152 | Submission Open

Keywords: antimicrobial resistance; surveillance systems; pathogen detection; rapid diagnostics; genomic surveillance; artificial intelligence; point-of-care testing; public health strategy; molecular epidemiology; big data analytics

Antimicrobial Peptides in Agriculture and Food Safety

edited by

Da Teng

submission deadline 31 Mar 2026 | Viewed by 151 | Submission Open

Keywords: AI-based discovery and design; biotechnology; mechanisms of action; novel delivery systems; animal husbandry; aquaculture; plant conservation; food preservation

Antibiotic Synthesis, 2nd Edition

edited by

Naresh Kumar

and

Tsz Tin Yu

submission deadline 31 Mar 2026 | Viewed by 147 | Submission Open

Keywords: new antimicrobial compounds; dual-action antimicrobials; new antimicrobial targets; targeted delivery of antibiotics; new scaffolds for antimicrobial discovery; discovery of new antimicrobial mechanisms

(This special issue belongs to the Section Novel Antimicrobial Agents)

Evaluation of Emerging Antimicrobials, 2nd Edition

edited by

Dilep Kumar Sigalapalli

submission deadline 31 Mar 2026 | Viewed by 79 | Submission Open

Keywords: antibacterials; antibiotics; antifungals; antimicrobial agents; antimicrobial resistance; antivirals; bacterial resistance; infections; multidrug resistance; pathogens

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Susceptibility Testing and Rapid Diagnostics of Antimicrobial Resistance

edited by Maria Grazia Bocci and Giulia Capecchi

submission deadline 31 Mar 2026 | Viewed by 68 | Submission Open

Keywords: antimicrobial resistance; antibiotic susceptibility testing; rapid diagnostics; molecular detection; point-of-care testing; clinical microbiology

Advanced Nanomaterials: Design, Synthesis, and Antibacterial Applications

edited by

Fei Pan

submission deadline 31 Mar 2026 | Viewed by 48 | Submission Open

Keywords: advanced nanomaterials; design; synthesis; antibacterial; applications

(This special issue belongs to the Section Antimicrobial Peptides)

Optimizing Empirical Antibiotic Therapy in Critical Care: Innovations in Diagnostics, Digitalization, and Stewardship

edited by

Mircea Stoian

and

Daniela C. Pasero

submission deadline 31 Mar 2026 | Viewed by 34 | Submission Open

Keywords: critical care; intensive care units; empirical antibiotic therapy; antimicrobial stewardship; rapid molecular diagnostics; digital health; artificial intelligence; antimicrobial resistance; targeted therapy; polypharmacy reduction; novel antibiotics; sepsis management

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antimicrobial Peptides: Mechanisms, Engineering, and Therapeutic Development

edited by

Feng-Di Lung

submission deadline 31 Mar 2026 | Viewed by 11 | Submission Open

Keywords: antimicrobial peptides (AMPs); peptide engineering; mechanisms of action; antibiotic resistance; host defense peptides; immunomodulation; drug delivery systems; synergy with antibiotics; therapeutic development; computational peptide design

(This special issue belongs to the Section Antimicrobial Peptides)

Beyond Bacteria: Exploring the Biology and Treatment of Understudied Fungal Biofilms

edited by

Whitni Redman

and

Wolf-Rainer Abraham

submission deadline 31 Mar 2026 | Viewed by 4 | Submission Open

Keywords: fungal biofilms; bacterial biofilms; interkingdom biofilms; host-pathogen interactions; biofilms and methodologies; mixed-species infections; therapeutics; fungal– bacterial interactions

(This special issue belongs to the Section Antibiofilm Strategies)

Genomic Characterization of Antimicrobial Resistance and Evolution Mechanism of Bacteria, 2nd Edition

edited by

Daniel Gyamfi Amoako

and

Linda Bester

submission deadline 31 Mar 2026 | Viewed by 4 | Submission Open

Keywords: antimicrobial resistance mechanism; mobile genetic element; horizontal gene transfer; resistome; evolution; molecular phylogenetics; genomics; bioinformatics analysis; next-generation sequencing

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antibiotic Choices for Pediatric Infections

edited by Theodouli Stergiopoulou

submission deadline 1 Apr 2026 | Viewed by 222 | Submission Open

Keywords: pediatric; neonatal infectious diseases; antimicrobial agents; antibiotic treatment

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antimicrobial Resistance of Staphylococcus spp. in Animals: A One Health Perspective

edited by Gi Yong Lee

submission deadline 5 Apr 2026 | 1 articles | Viewed by 625 | Submission Open

Keywords: staphylococci; molecular epidemiology; antimicrobial resistance; One Health; multiomics

(This special issue belongs to the Section Antibiotics in Animal Health)

Antibiotic Resistance in a One Health Context: Bridging Environmental, Agricultural, Nutritional, Veterinary, and Clinical Perspectives

edited by

Pedro A. Jiménez Gómez

and

Marina Robas Mora

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1738 | Submission Open

Keywords: antibiotic resistance; One Health; environmental microbiology; zoonotic pathogens; antimicrobial stewardship; resistance mechanisms; horizontal gene transfer; integrated surveillance; microbial ecology; public health

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Peptides: An Emerging Hope in the Era of New Infections and Resistance, 2nd Edition

edited by

Piyush Baindara

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1216 | Submission Open

Keywords: antimicrobial peptides; antimicrobial resistance; infectious diseases; antibacterial; antifungal; immunomodulatory properties; therapeutics; evolution

(This special issue belongs to the Section Antimicrobial Peptides)

Evidence in Antibiotic Mastitis Therapy

edited by

Volker Krömker

and

Paolo Moroni

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1084 | Submission Open

Keywords: antibiotic mastitis treatment; targeted; selective; pathogens; mastitis history; new infections

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Stewardship—from Projects to Standard of Care

edited by Gesche Först and Franky Buyle

submission deadline 30 Apr 2026 | 1 articles | Viewed by 903 | Submission Open

Keywords: antimicrobial stewardship; antimicrobial use; antibiotics; implementation; efficacy; quality; antimicrobial prescribing

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Advanced Nanomaterials and Bioinspired Strategies for Antimicrobial Applications

edited by

Amedea B. Seabra

, Gerson Nakazato and

Roberta Albino Dos Reis

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: antimicrobial nanomaterials; bioinspired materials; biomaterials engineering; antimicrobial resistance (AMR); nanostructured antimicrobials; bionanotechnology; green chemistry; antibacterial coatings

(This special issue belongs to the Section Novel Antimicrobial Agents)

Distribution, Sources and Risks of Bacteria and Their Antimicrobial Resistance Genes in the Environment, 2nd Edition

edited by Filip Gamoń,

Ewa Kotlarska

and Suparna Mitra

submission deadline 30 Apr 2026 | Viewed by 75 | Submission Open

Keywords: antimicrobial resistance (AMR) and One Health; AMR dissemination in the environment; risk assessment of AMR in environmental reservoirs (agroecosystems); antibiotic-resistant pathogenic and resident bacteria; antibiotic-resistance gene (ARG) transfer; ARG quantification; AMR and food/feed chain; antibiotics in animals; agrochemicals; antibiotic residues

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antibiotic Susceptibility Testing Guides Clinical Treatment Decisions: From Empiric to Targeted Therapy

edited by

Jan Závora

, Simona Arientová and

Christopher K. C. Lai

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: antimicrobial susceptibility testing; antimicrobial resistance; empiric antimicrobial therapy; targeted antimicrobial therapy; clinical microbiology; infectious diseases; antimicrobial stewardship; infectious disease management; multidrug-resistant organisms

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobial Plant Peptides as Prototypes of New Antifungal Drugs

edited by

Ekaterina I. Finkina

submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open

Keywords: fungal infections; fungal virulence factors; fungal resistance; plant antimicrobial peptides (AMPs); antifungal activity; prevention of fungal adhesion and biofilm formation; immunomodulatory properties; structure-activity relationships; peptide engineering

Pharmacokinetic and Antibiotic Dosing for Intensive Care Unit Patients, 2nd Edition

edited by

Yuhki Sato

submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open

Keywords: antibiotics; pharmacokinetics– pharmacodynamics; therapeutic drug monitoring; population pharmacokinetics analysis; bacterial susceptibility

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Exploring Synthetic Organic Chemistry to Combat Pathogenic Infections

edited by

Cătălin Araniciu

Ioana Ionuț

and

Gabriel Marc

submission deadline 30 Apr 2026 | Viewed by 47 | Submission Open

Keywords: synthetic organic chemistry; antimicrobial agents; structure– activity relationship (SAR); drug design; molecular docking; drug discovery

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Therapies for Multidrug-Resistant Infections

edited by

Antonio Riccardo Buonomo

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: MDR; gram-negative infections; acinteobacter baumannii; stenotrophomonas maltophilia; KPC; MBL

Antibiotic Use and the Emergence of Antibiotic Resistance in Clinical Settings, 2nd Edition

edited by

Aleksandra Barac

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: antibiotic use; antibiotic resistance; clinical settings; clinical infections; mechanisms underlying the development of resistance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antibiotics and Environment—Research and Development Toward the One Health Approach, 2nd Edition

edited by

Takashi Azuma

submission deadline 30 Apr 2026 | Viewed by 35 | Submission Open

Keywords: antimicrobial resistance (AMR); antimicrobials; water purification plant (WTP); wastewater treatment plant (WWTP); hospital wastewater; livestock environment; aquaculture farm environment; aquatic environment

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Rapid Antifungal Susceptibility Testing and Diagnostics of Antifungal Resistance

edited by Valentina Salas

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: antifungal resistance; drug resistance mechanisms; multidrug resistance; intrinsic resistance and acquired resistance; new resistant opportunistic fungi

Multidrug-Resistant Microorganisms: Overcoming the Challenges in Antibiotic Treatment

edited by Eleni E. Mylona and

Dimitris Kounatidis

submission deadline 30 Apr 2026 | Viewed by 8 | Submission Open

Keywords: multidrug-resistant; antibiotic treatment; MDR pathogens; therapeutic strategies

Antibiotic Prescribing in Primary Dental Care—2nd Edition

edited by

Kristina Peros

submission deadline 30 May 2026 | Viewed by 116 | Submission Open

Keywords: primary dental care; antibiotic prescribing; rational drug prescribing; antibiotic stewardship

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Innovative and Translational Antibiosis Approaches to Tackling Protozoan Parasites: Synergy, Drug Repurposing, Natural Products, Molecular Targets, and Therapeutic Design

edited by

Leonardo Acuña

submission deadline 30 May 2026 | Viewed by 58 | Submission Open

Keywords: drug repurposing for neglected tropical diseases; natural products with antiparasitic activity; synergistic drug combinations; molecular targets and mechanisms of action

Antimicrobial Stewardship in Neonatal Intensive Care

edited by Chiara Poggi

submission deadline 30 May 2026 | Viewed by 19 | Submission Open

Keywords: neonatal sepsis; early onset sepsis; late onset sepsis; preterm; antimicrobial stewardship; neonatal intensive care; molecular diagnosis; stopping rule; therapeutic drug monitoring; extended antimicrobial infusion; continuous antimicrobial infusion; microbiological surveillance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Optimizing Antimicrobial Therapy in NICU Settings: Strategies and Implications

edited by

Elias Iosifidis

and

Angeliki Kontou

submission deadline 31 May 2026 | 1 articles | Viewed by 2551 | Submission Open

Keywords: neonatal ICU; antimicrobial stewardship; antimicrobial resistance; neonatal sepsis; biomarkers

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Periprosthetic Joint Infection: Understanding the Epidemiology, Pathogenesis, Diagnosis and Treatment Options

edited by Saad Tarabichi, Mark J. Spangehl and Joshua S. Bingham

submission deadline 31 May 2026 | 2 articles | Viewed by 1733 | Submission Open

Keywords: periprosthetic joint infection; diagnosis; epidemiology; pathogenesis; treatment

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Rethinking Mild Infections: The Role of Natural Products in Antimicrobial Stewardship

edited by

Karel Kostev

submission deadline 31 May 2026 | Viewed by 86 | Submission Open

Keywords: natural products; herbal products; phytopharmaceutical; antimicrobial resistance; respiratory tract infections; urinary tract infections

Antimicrobial Nanomaterials: Advances, Challenges, and Future Perspectives

edited by

Nuno Miguel Figueiredo

and Daniela Santo

submission deadline 31 May 2026 | Viewed by 58 | Submission Open

Keywords: antimicrobial nanomaterials; metal and metal oxide nanoparticles and nanocomposites; carbon-based nanomaterials; polymeric and hybrid nanostructures; photocatalytic nanomaterials; multifunctional antimicrobial coatings; antimicrobial mechanisms of action; biocompatibility and toxicity

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Antimicrobial Resistance in Animals and Animal Products and Its Environmental Transmission Aspects, Second Edition

edited by

Nikolaos Solomakos

Thomai Lazou

and

Andreana Pexara

submission deadline 31 May 2026 | Viewed by 30 | Submission Open

Keywords: antimicrobial resistance; One Health; AMR dissemination in the environment; antibiotics in animals; foodborne pathogens; animal products

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Resistance and Intervention Strategies in Intestinal Pathogens: A One Health Approach

edited by Gaetano Iaquinto

submission deadline 31 May 2026 | Viewed by 30 | Submission Open

Keywords: epidemiology; antimicrobial resistance; multi-drug resistance; immunomodulatory activity; cytokines; gut microbiota; new antibiotics research; new vaccines; faecal microbiota transplantation; infection prevention

Antimicrobial Therapeutics for Bone and Periprosthetic Joint Infection, 2nd Edition

edited by

Éric M. Senneville

submission deadline 31 May 2026 | Viewed by 27 | Submission Open

Keywords: osteomyelitis; diabetic foot osteomyelitis; periprosthetic joint infections; antimicrobial therapy; recurrence; persistence; biofilm

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Diagnostics, Antibiotic Usage and Surgery Related Techniques in Prevention and Treatment of Prosthetic Joint and Implant Related Infections

edited by

Bernd Fink

and

Steffen Ruchholtz

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2323 | Submission Open

Keywords: periprosthetic joint infection; implant-related infection; antibiotics; spacer; diagnosis; septic revision arthroplasty; irrigation; debridement

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

New Drugs, Innovative Antimicrobial Approaches, and Optimized Dosages: Bridging Research and Clinical Practice

edited by

Jerónimo Pachón

, Rocío Álvarez-Marín and

María E. Pachón-Ibáñez

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1417 | Submission Open

Keywords: antibiotics; antivirals; pharmacokinetics and pharmacodynamics; clinical evaluation; experimental studies; new antimicrobial approaches

Recent Developments in Antimicrobial Resistance Epidemiology and Antimicrobial Therapy for Clinically Relevant Bacteria

edited by

Georgios Meletis

submission deadline 30 Jun 2026 | Viewed by 122 | Submission Open

Keywords: antimicrobial resistance mechanisms; antimicrobial resistance detection; antimicrobial resistance epidemiology; antimicrobial treatment; MDR; Klebsiella pneumoniae; Acinetobacter baumannii; Pseudomonas aeruginosa; MRSA; VRE

Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology, 2nd Edition

edited by

Theodoros Karampatakis

and

Katerina Tsergouli

submission deadline 30 Jun 2026 | Viewed by 113 | Submission Open

Keywords: Gram-negative bacteria; virulence factors; antimicrobial resistance; molecular epidemiology; Klebsiella pneumoniae; Pseudomonas aeruginosa; Acinetobacter baumannii

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

New Approaches to the Treatment and Prevention of Fungal Infections

edited by