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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Antimicrobial Strategies to Combat Antibiotic Resistance

edited by

Chenxi Huang

and

Xiaohong Wang

submission deadline 30 Sep 2025 | Viewed by 247 | Submission Open

Keywords: nanotechnology applications; diagnostic strategies; phages-mediated strategies; foodborne pathogens; antibiotics; antimicrobial; multi-drug resistance; biocontrol

(This special issue belongs to the Section Novel Antimicrobial Agents)

Bone and Joint Infections: The Challenges of Prevention, Diagnosis and Treatment and Opportunities for Future Research

edited by

Natividad Benito

submission deadline 30 Sep 2025 | Viewed by 205 | Submission Open

Keywords: bone and joint infection; arthroplasty infection; definition of bone and joint infection; bone and joint joint infection prevention; diagnosis of bone and joint infection; bone and joint infection management; antimicrobial therapy of bone and joint infection

Epidemiology and Antimicrobial Dosing Regimens in Intensive Care Units

edited by

Philipp Simon

submission deadline 30 Sep 2025 | Viewed by 181 | Submission Open

Keywords: epidemiology; critical care; sepsis; empiric therapy; dosing; interactions; antibiotic resistance; therapeutic drug monitoring; pharmacokinetics/pharmacodynamics; renal insufficiency; renal replacement therapy

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Biomaterial-Based Delivery Systems for Natural Antimicrobials to Overcome Microbial Resistance

edited by

Ioana Cristina Marinas

Irina Gheorghe-Barbu

and Ilda Czobor-Barbu

submission deadline 30 Sep 2025 | Viewed by 113 | Submission Open

Keywords: antimicrobial resistance (AMR); virulence and pathogenicity; phytocompounds; biomaterials; controlled release; nanoparticles; biopolymers; targeted delivery; biofilm prevention; sustainable therapeutics

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

A Themed Issue in Honor of Prof. Dr. Rob Capon—Outstanding Contributions in the Field of Anti-Infectives

edited by Mark Butler

submission deadline 30 Sep 2025 | Viewed by 109 | Submission Open

Keywords: natural product; microorganism; bacteria; fungi; marine antibiotic; antibacterial; antheminthic; crop protection

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Resistance in a One Health Context: Bridging Environmental, Agricultural, Nutritional, Veterinary, and Clinical Perspectives

edited by

Pedro A. Jiménez Gómez

and

Marina Robas Mora

submission deadline 30 Sep 2025 | Viewed by 103 | Submission Open

Keywords: antibiotic resistance; One Health; environmental microbiology; zoonotic pathogens; antimicrobial stewardship; resistance mechanisms; horizontal gene transfer; integrated surveillance; microbial ecology; public health

Emerging Contaminants: Antibiotic Residues and Their Environmental Impact

edited by

Xuxiang Zhang

Liping Ma

and Peng Liu

submission deadline 30 Sep 2025 | Viewed by 97 | Submission Open

Keywords: antibiotics; antimicrobial resistance; environmental behavior; environmental pollution; health risk; high-throughput sequencing; resistome; non-target screening

Surveillance and Assessment of Antimicrobial Resistance Patterns and Antimicrobial Utilization in Hospital Settings

edited by Hao-Yuan Lee

submission deadline 30 Sep 2025 | Viewed by 92 | Submission Open

Keywords: antimicrobial resistance (AMR); antimicrobial stewardship; hospital-acquired infections; surveillance systems; antibiotic prescribing practices; infection prevention and control; diagnostic tools in AMR; resistance trends in healthcare; epidemiology of AMR; multidrug-resistant organisms (MDROs)

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Genomic Surveillance of Antimicrobial Resistance (AMR)

edited by Linzy Elton

submission deadline 30 Sep 2025 | Viewed by 82 | Submission Open

Keywords: antimicrobial resistance; sequencing; genomics; surveillance; mobile genetic elements; multi-drug-resistant organisms; One Health; metagenomics; whole-genome sequencing

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Metal-Based Complexes as Novel Antimicrobial Strategies

edited by

Alberto Aragón-Muriel

Dorian Polo Cerón

and

David Morales-Morales

submission deadline 30 Sep 2025 | Viewed by 80 | Submission Open

Keywords: antibiotics; metal-based complexes; antimicrobial resistance; antimicrobial therapy; drug design; bioinorganic; metallodrug; metallopharmaceutical

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antimicrobial Activity of Medical Materials, 2nd Edition

edited by Tânia Grainha and Susana Lopes

submission deadline 30 Sep 2025 | Viewed by 77 | Submission Open

Keywords: antimicrobial surfaces; copper; silver; surface functionalization/modifications; biofilm prevention; medical textiles; efficiency

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Molecular Epidemiology and Antibiotic Resistance in MRSA: Recent Advances in Surveillance and Control

edited by

Jae-Seok Kim

submission deadline 30 Sep 2025 | Viewed by 74 | Submission Open

Keywords: Staphylococcus aureus; methicillin-resistant S. aureus (MRSA); hospital-associated MRSA (HA-MRSA); antimicrobial resistance; molecular epidemiology; evolution of resistance; surveillance

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Bioactives from Invertebrates

edited by

Beatriz Vázquez Belda

submission deadline 30 Sep 2025 | Viewed by 67 | Submission Open

Keywords: invertebrates; bioactive compounds; antimicrobials; antibacterial activity; marine invertebrates; insects; worms; crustaceans; mollusks

(This special issue belongs to the Section Novel Antimicrobial Agents)

Application of Bacteriophages Against Bacterial Survival Strategies

edited by Sang Guen Kim

submission deadline 30 Sep 2025 | Viewed by 44 | Submission Open

Keywords: bacteriophage; phage therapy; application of phages; biofilm; persister cells; viable but non-culturable (VBNC)

(This special issue belongs to the Section Bacteriophages)

Epidemiology and Genomics of Antimicrobial Resistance of Difficult-to-Treat Pathogens

edited by Simone Ambretti

submission deadline 30 Sep 2025 | Viewed by 8 | Submission Open

Keywords: antimicrobial resistance; difficult-to-treat pathogens; epidemiology; genomics; MRSA; VRE; ESBL; CRE; CRAB; MDR pseudomonas aeruginosa

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Molecular Characterization of Multidrug-Resistant Pathogens

edited by

Viviana Cafiso

and

Maria Santagati

submission deadline 30 Sep 2025 | Viewed by 7 | Submission Open

Keywords: MDR pathogens; One-Health; genomic; transcriptomic; phylogenomics; molecular epidemiology; AMR

(This special issue belongs to the Section Genetic and Biochemical Studies of Antibiotic Activity and Resistance)

Addressing the Challenge of Antibiotic Resistance with Existing Antibiotics

edited by Xuanxian Peng

submission deadline 5 Oct 2025 | 1 articles | Viewed by 803 | Submission Open

Keywords: antibiotic resistance; antibacterial agents; metabolites; antibiotic-resistant bacteria

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Microbial Resistance Surveillance and Management in Food Systems

edited by

Carlos Adam Conte Júnior

and

Bruno Dutra da Silva

submission deadline 10 Oct 2025 | 5 articles | Viewed by 2404 | Submission Open

Keywords: cross-contamination; microbial resistance; microbial monitoring; public health; alternative antimicrobials; foodborne illnesses; food microbiology

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

The Antimicrobial Activity of Metal-Based Nanoparticles

edited by Suzan Pantaroto de Vasconcellos

submission deadline 15 Oct 2025 | 1 articles | Viewed by 974 | Submission Open

Keywords: metal-nanoparticle; microbicide; virucide; phytopathogens; disinfectant; synthesis; antibiotic resistance

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Perspective on the Role of Farm Animals in the Transmission of Antimicrobial Resistance from a One Health Approach

edited by

Romeo Teodor Cristina

and

Degi Janos

submission deadline 15 Oct 2025 | Viewed by 290 | Submission Open

Keywords: antimicrobials use; farm animals; antimicrobial resistance; one health; antimicrobials; food safety; public health

(This special issue belongs to the Section Antibiotics in Animal Health)

Veterinary Microbiology and Antimicrobial Resistance—the One Health Approach

edited by

George Cosmin Nadǎş

submission deadline 15 Oct 2025 | 1 articles | Viewed by 227 | Submission Open

Keywords: antimicrobial resistance; veterinary microbiology; MDR; one health; zoonotic

(This special issue belongs to the Section Antibiotics in Animal Health)

Fighting the Superbug Surge: Strategies in Antimicrobial Stewardship and Infection Control

edited by Sara Revolinski, Kristen Bresnehan and Lucas Schulz

submission deadline 15 Oct 2025 | Viewed by 158 | Submission Open

Keywords: antimicrobial stewardship; infection control; infection prevention; multidrug resistant organisms; antimicrobial resistance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

The Role of the Gut Microbiome in Antibiotic Resistance and Therapy: Mechanisms and Implications

edited by

Dóra Szabó

submission deadline 15 Oct 2025 | Viewed by 38 | Submission Open

Keywords: gut microbiome; antibiotic resistance; antibiotic therapy; pre- and probiotics; horizontal gene transfer; ESBL-producing enterobacterales; Carbapenem-resistant enterobacterales; intestinal colonization; clostrioides difficile; fecal microbiota transplantation (FMT)

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

The Application of Antibiotic Therapy in Oral Surgery and Dental Implant Procedures, 2nd Edition

edited by

Angel-Orion Salgado-Peralvo

and

Eugenio Velasco-Ortega

submission deadline 20 Oct 2025 | Viewed by 32 | Submission Open

Keywords: antibiotics; preventive antibiotic therapy; antibiotic prophylaxis; bacterial antibiotic resistance; antibiotic resistance; oral implantology; dental implantology; dental implants; dentistry; oral surgery

Revolutionizing Infection Treatment: Cutting-Edge Approaches in Antimicrobial Stewardship

edited by Jacob Myles Keck and

Aleksandra Barac

submission deadline 30 Oct 2025 | Viewed by 113 | Submission Open

Keywords: antimicrobial stewardship; antimicrobial resistance; infection treatment optimization; rapid diagnostics; technology in healthcare

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Mechanism of Carbapenem Resistance in Enterobacteriaceae, Acinetobacter and Pseudomonas aeruginosa

edited by

Ágnes Pál-Sonnevend

submission deadline 31 Oct 2025 | 5 articles | Viewed by 14430 | Submission Open

Keywords: gram-negative infections; mechanism of carbapenem resistance; molecular epidemiology; in vitro diagnostic tools; antimicrobial treatment; beta-lactam/beta lactamase inhibitors; cefiderocol

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

New Paradigms Concerning the Production of Antibiotics: Between Ecological Responsibility and Revalorization of Narrow Spectrums

edited by

Véronique Mondain

submission deadline 31 Oct 2025 | 3 articles | Viewed by 8722 | Submission Open

Keywords: one health; environmental pollution; human health; antimicrobial production; livestock; antimicrobial resistance; antimicrobial stewardship

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Diagnosis and Antimicrobial Therapy of Osteoarticular Infection

edited by Janet D. Conway

submission deadline 31 Oct 2025 | 4 articles | Viewed by 8655 | Submission Open

Keywords: bone infection; joint infection; periprosthetic joint infection; orthopaedic infection; orthopedic infection

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Emerging Topics in Clostridioides difficile Infection: A One Health Problem

edited by

Simon D. Baines

submission deadline 31 Oct 2025 | 2 articles | Viewed by 3690 | Submission Open

Keywords: clostridium difficile infection (CDI); antimicrobial resistance (AMR); antimicrobial prescribing; one health; laboratory studies

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Biofilms and Urinary Tract Infections

edited by

Dino Sgarabotto

and

Anabela Borges

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1983 | Submission Open

(This special issue belongs to the Section Antibiofilm Strategies)

Antibiotics: Utilization, Resistance, and Infection Prevention

edited by

Tafadzwa Dzinamarira

and

Claude Mambo Muvunyi

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1400 | Submission Open

Keywords: antibiotic resistance; antimicrobial stewardship; infection prevention; antibiotic stewardship programs; antimicrobial resistance mechanisms; infection control; rapid diagnostics; public health and AMR; antibiotic alternatives; surveillance systems

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Etiology, Clinical Presentation, Antibiotic and Surgical Treatment of Infective Endocarditis

edited by Francesco Santini,

Francesco Onorati

and

Antonio Salsano

submission deadline 31 Oct 2025 | Viewed by 496 | Submission Open

Keywords: infective endocarditis; acute; bacterial; diagnosis; treatment; valvular heart disease; cardiac surgery; cardiac prosthesis; complications; intensive care

Environmental Fate and Effects of Antibiotics and Antibiotic Resistance Genes, 2nd Edition

edited by

Anna Barra Caracciolo

and Ludovica Rolando

submission deadline 31 Oct 2025 | Viewed by 308 | Submission Open

Keywords: antibiotic-resistant bacteria; antibiotic resistance genes; environmental spread; bioaccumulation; biodegradation; antibiotic mixture

Pathogenesis, Epidemiology and Antibiotic Resistance of Salmonella

edited by

Angela Pista

and

Leonor Silveira

submission deadline 31 Oct 2025 | Viewed by 291 | Submission Open

Keywords: Salmonella; epidemiology; genomics; public health; antimicrobial resistance; One-Health approach

Antibiotics in the Environment: Sources, Fate, and Mitigation Strategies

edited by Khaled Benis

submission deadline 31 Oct 2025 | Viewed by 246 | Submission Open

Keywords: antibiotic contamination; environmental fate; antibiotic resistance; mitigation strategies; pollution management

Structure and Function of Antimicrobial Peptides

edited by Daniel Balleza and

Gill Diamond

submission deadline 31 Oct 2025 | Viewed by 203 | Submission Open

Keywords: antimicrobial peptides; natural peptides; lipidomics; synergistic action; bioactivity mechanisms; structure reconfiguration

(This special issue belongs to the Section Antimicrobial Peptides)

Antimicrobial Properties of Essential Oils: Activities, Mechanisms, Applications, and Therapeutic Potential

edited by

Eduardo Valarezo

Miguel Ángel Meneses

and Matteo Radice

submission deadline 31 Oct 2025 | Viewed by 156 | Submission Open

Keywords: antibiotics; antibacterial; antifungal; antiviral; ethnopharmacology; multidrug resistance; natural products; resistant strains; volatile secondary metabolites; volatile compounds

(This special issue belongs to the Section Plant-Derived Antibiotics)

Combating Antimicrobial Resistance Spread in Food and Drinks Using Bacteriophage Technologies

edited by

Janet Nale

submission deadline 31 Oct 2025 | Viewed by 131 | Submission Open

Keywords: bacteriophage; phage therapy; antimicrobial resistance; food; drink; water; agriculture; pathogenic bacteria; lytic phages; lysogens; prophages; temperate phage

(This special issue belongs to the Section Bacteriophages)

Antimicrobial Activity of Natural Products and Plants Extracts, 2nd Edition

edited by

Mihaela Niculae

and

Daniela Hanganu

submission deadline 31 Oct 2025 | Viewed by 66 | Submission Open

Keywords: natural products; plant extracts; bioactive compounds; phytoconstituents; antibacterial efficacy; in vitro screening; in vivo evaluation; antibiofilm; anti-quorum

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antimicrobial Resistance, Epidemiology, Clinical Impact and Molecular Characterization of Multidrug-Resistant ESKAPEE Pathogens

edited by

Lorenzo Pace

and Viviana Manzulli

submission deadline 31 Oct 2025 | Viewed by 35 | Submission Open

Keywords: ESKAPEE; antimicrobial resistance; antibiotic resistance; multidrug-resistant pathogens; nosocomial infection; molecular mechanism

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Novel Preventive and Therapeutic Strategies to Eradicate Biofilm Infections Based on New Antibacterial Compounds

edited by

María Guembe

submission deadline 31 Oct 2025 | Viewed by 24 | Submission Open

Keywords: antibacterial; biofilm; infection; innovation; microbiota

(This special issue belongs to the Section Antibiofilm Strategies)

Novel Antimicrobial Strategies to Combat Multidrug-Resistant (MDR) Gram-Negative Bacteria, 2nd Edition

edited by

Valerie Carabetta

submission deadline 31 Oct 2025 | Viewed by 18 | Submission Open

Keywords: gram negative; antibiotic resistance; antiseptic resistance; multidrug resistant; extensively drug resistant; pandrug resistant; MDR; XDR; PDR; efflux pumps; mechanisms of resistance; beta-lactamase; outer membrane

Prevalence, Treatment and Antibacterial Resistance of Urinary Tract Infections

edited by Alin Gabriel Mihu and

Tudor Rares Olariu

submission deadline 31 Oct 2025 | Viewed by 10 | Submission Open

Keywords: urinary tract infections; UTI; antibiotic; antibacterial; resistance; uropathogens; recurrent UTI; Enterobacteriaceae; Escherichia coli

Biotechnological Production of Novel Antimicrobials

edited by

Vanja Vlajkov

Jovana Grahovac

and

Ivana Danilov

submission deadline 1 Nov 2025 | Viewed by 214 | Submission Open

Keywords: antibiotic resistance; biotechnology; antimicrobial activity; disease outbreak; pathogens; microorganisms; genetic engineering; artificial intelligence; optimisation; biocontrol

New Natural Products as Candidates for the Discovery of Antimicrobial Drugs

edited by

Maya Zaharieva

and

Hristo Najdenski

submission deadline 15 Nov 2025 | 4 articles | Viewed by 4371 | Submission Open

Keywords: natural products; antimicrobial mechanisms and strategies; combination effects; clinical applicability; in silico; in vitro and in vivo models; infection control

(This special issue belongs to the Section Plant-Derived Antibiotics)

Pathogenic Microorganisms and Antibiotic Therapy in Infectious Disease

edited by

Angela Quirino

Grazia Pavia

and

Nadia Marascio

submission deadline 15 Nov 2025 | 2 articles | Viewed by 4094 | Submission Open

Keywords: antimicrobial resistance; pathogenic mechanisms; multidrug-resistant microorganisms; antimicrobial drugs; innovative therapeutic strategies

Antibiotic and Antiparasitic Resistance in Veterinary Clinical Settings

edited by

Daphne Lianou

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1975 | Submission Open

Keywords: animal; cattle; cat; dog; goat; horse; pig; poultry; sheep; therapeutics; treatment; veterinary; wildlife

(This special issue belongs to the Section Antibiotics in Animal Health)

Innovations in Plant-Based Antibiotic and Antiviral Agents

edited by

Margherita-Gabriella De Biasi

and

Irene Dini

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1154 | Submission Open

Keywords: secondary metabolites; phytochemicals; botanicals; analytical methods; toxicity

(This special issue belongs to the Section Plant-Derived Antibiotics)

The Antimicrobial Resistance in the Food Chain

edited by

Irene Dini

submission deadline 30 Nov 2025 | Viewed by 333 | Submission Open

Keywords: food safety; foodborne pathogens; pathways of antimicrobial resistance; antibiotic resistance; phenotypic analyses; molecular analyses; regulatory guidelines; food chemistry

Mastitis: Causative Agents, Drug Resistance, and Treatment Approaches—2nd Edition

edited by