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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oxidative Stress and NRF2 in Health and Disease—2nd Edition

edited by

Lidija Milković

submission deadline 20 Nov 2025 | 9 articles | Viewed by 19524 | Submission Open

Keywords: oxidative stress; redox signaling; NRF2 and its regulation; redox-modifying therapeutic approach; omics approach; physiology; non-communicable diseases; metabolism; aging

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Alcohol-Induced Oxidative Stress in Health and Disease, 2nd Edition

edited by

Marco Fiore

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5094 | Submission Open

Keywords: alcohol; alcohol use disorder; reactive oxygen species; antioxidant defense

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Hepatic Diseases

edited by

Miquel Mulero

submission deadline 21 Nov 2025 | 3 articles | Viewed by 6248 | Submission Open

Keywords: oxidative stress; hepatic diseases; liver fibrosis; reactive oxygen species (ROS); mitochondrial dysfunction; lipid peroxidation; antioxidant defense; non-alcoholic fatty liver disease (NAFLD); alcoholic liver disease; hepatoprotective strategies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants from Food and Food Wastes for Nutraceutical, Pharmaceutical and Cosmetic Fields

edited by Monica Locatelli and

Vincenzo Disca

submission deadline 25 Nov 2025 | 8 articles | Viewed by 18716 | Submission Open

Keywords: phenolic compounds; analytical methods; bioactivities; green extraction; functional ingredients; food supplements; by-products and up-cycled ingredients; nutraceutical; cosmetics; bioaccessibility

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Antioxidant Compounds and Health Benefits of Mediterranean Functional Food

edited by

Stefania D'Angelo

submission deadline 25 Nov 2025 | 3 articles | Viewed by 4997 | Submission Open

Keywords: antioxidants; anti-inflammatory; anti-obesity; functional food; human health; Mediterranean diet; nutraceuticals; nutrition; oxidative stress; phytochemicals; polyphenols

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress in Animal Reproduction and Nutrition

edited by

Fang Chen

and

Jun Chen

submission deadline 28 Nov 2025 | 4 articles | Viewed by 4402 | Submission Open

Keywords: oxidative stress; antioxidants; animal reproduction; nutritional regulation; livestock and poultry; mouse or rat model; antioxidant mechanisms; oxidative stress mechanisms

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants in Meat and Meat Products

edited by

Rubén Domínguez-Valencia

and

Mirian Pateiro

submission deadline 28 Nov 2025 | Viewed by 250 | Submission Open

Keywords: natural antioxidants; oxidative degradation; meat shelf-life; food quality; functional food; bioactive compounds; antioxidant active packaging

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Antioxidants and Retinal Diseases—2nd Edition

edited by

Francisco J. Romero

and Jorge M. Barcia

submission deadline 30 Nov 2025 | 8 articles | Viewed by 34344 | Submission Open

Keywords: retinal diseases; antioxidants; oxygen species; extracellular vesicles; miRNA

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Therapy for Obesity-Related Diseases

edited by

Seyed Khosrow Tayebati

submission deadline 30 Nov 2025 | 8 articles | Viewed by 19020 | Submission Open

Keywords: obesity; inflammation; oxidative stress; organ damage; natural antioxidants; synthetic antioxidants; mechanisms of action; therapeutical approaches

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Natural Products: Biological, Antioxidant Properties and Health Effects—4th Edition

edited by

Evangelos Zoidis

submission deadline 30 Nov 2025 | 10 articles | Viewed by 17956 | Submission Open

Keywords: algal antioxidants; agricultural by-products; algae; bioactive compounds; cancer; cardiovascular diseases; essential oils; inflammatory diseases; marine organisms; metabolic diseases; oxidative stress; phytochemicals; polyphenols; radical scavenging; shelf life; waste products

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Free Radicals, Antioxidants, and Oxidative Stress in Aging and Age-Related Diseases—2nd Edition

edited by

Abdelouahed Khalil

and

Tamas Fulop

submission deadline 30 Nov 2025 | 5 articles | Viewed by 16426 | Submission Open

Keywords: aging; oxidative stress; age-related diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Cancer

edited by

and

submission deadline 30 Nov 2025 | 4 articles | Viewed by 13690 | Submission Open

Keywords: ascorbate; vitamin C; cancer therapy; cancer prevention; antioxidants; prooxidants; oxidative stress; epigenetic activity

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Novel Antioxidants for Animal Nutrition—2nd Edition

edited by

Matteo Dell'Anno

and

Luciana Rossi

submission deadline 30 Nov 2025 | 6 articles | Viewed by 12227 | Submission Open

Keywords: nutrition; functional diets; innovative antioxidants; feed additives; natural extracts; disease prevention; oxidative stress; one health

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Eye Diseases

edited by

Dhirendra Pratap Singh

and

Eri Kubo

submission deadline 30 Nov 2025 | 5 articles | Viewed by 9727 | Submission Open

Keywords: oxidative stress; antioxidants; reactive oxygen species; redox signaling; inflammatory cell death; age-related blinding diseases; glaucoma; cataract; age-related macular degeneration; gene regulation; retinal disorder; dry eye disorder; corneal diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection—2nd Edition

edited by

Maja Jazvinšćak Jembrek

and

Josipa Vlainić

submission deadline 30 Nov 2025 | 5 articles | Viewed by 9445 | Submission Open

Keywords: neuroprotection; neurotoxicity; antioxidative vs. proxidative; oxidative stress; signaling pathways; redox metals

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Reactive Oxygen and Nitrogen Species in Plants―2nd Edition

edited by

Francisco J. Corpas

Rosa M. Rivero

and

José M. Palma

submission deadline 30 Nov 2025 | 4 articles | Viewed by 8050 | Submission Open

Keywords: antioxidants; hydrogen peroxide; nitric oxide; nitro-oxidative stress; ROS; RNS; hydrogen sulfide; melatonin

(This special issue belongs to the Section ROS, RNS and RSS)

The Interaction Between Gut Microbiota and Host Oxidative Stress

edited by

Jie Yin

submission deadline 30 Nov 2025 | 3 articles | Viewed by 7151 | Submission Open

Keywords: oxidative stress; antioxidants; gut microbiome; immunity

Developmental Origins of Health and Disease: Antioxidants as Strategy for Prevention and Treatment

edited by

Silvia M. Arribas

and

David Ramiro-Cortijo

submission deadline 30 Nov 2025 | 4 articles | Viewed by 7055 | Submission Open

Keywords: oxidative stress; pregnancy; germline damage; obstetric complications; fetal programming

Glutathione and Health: From Development to Disease

edited by

Ying Chen

and Vasilis K. Vasiliou

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5429 | Submission Open

Keywords: glutathione; antioxidants; antioxidant enzymes; oxidative stress; redox biology; molecular biology; cellular biology; biochemistry; development; disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Inflammation in Neurologic Diseases

edited by

Adriana Bulboaca

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4839 | Submission Open

Keywords: oxidative stress; nitrosative stress; neuroinflammation; neurodegeneration; neuronal apoptosis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Antioxidants in Hypoxia and Human Pathophysiology Settings, 2nd Edition

edited by

Rodrigo L. Castillo

and Alejandro Gonzalez-Candia

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3970 | Submission Open

Keywords: tissue hypoxia; reperfusion injury; hypoxic preconditioning; oxidative stress; antioxidants; hypoxic programing; microRNA; clinical hypoxic settings

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants from Plant-Based By-Products: Mechanisms and Applications in Food Systems

edited by

María Jesús Petrón Testón

submission deadline 30 Nov 2025 | 4 articles | Viewed by 3880 | Submission Open

Keywords: natural antioxidants; plant-based by-products; phenolic compounds; food preservation; shelf life extension; sustainable food systems; extraction techniques

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Redox Signaling in Cancer: Mechanisms and Therapeutic Opportunities

edited by

Myoung Ok Kim

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2852 | Submission Open

Keywords: oxidative stress; cancer; reactive oxygen species (ROS); redox signaling; natural compounds; ferroptosis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Inflammation and Oxidative Stress in Articular Cartilage

edited by

Carmelita G. Frondoza

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2390 | Submission Open

Keywords: cartilage; chondrocyte; joint inflammation; arthritis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Hydrogen Sulfide, Reactive Sulfur Species, and Donor Compounds: Natural and Synthetic Tools for Physiology and Disease

edited by

Giuseppe Caliendo

and

Angela Corvino

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1497 | Submission Open

Keywords: hydrogen sulfide; H2S donors; H2S hybrid compounds; H2S sources; pharmacological tools; H2S signaling

Berry Antioxidants in Health and Disease—2nd Edition

edited by

Dorothy Klimis-Zacas

and

Sarah A. Johnson

submission deadline 30 Nov 2025 | 1 articles | Viewed by 979 | Submission Open

Keywords: berries; antioxidants; polyphenols; berry metabolites; oxidative stress; chronic diseases; cardiovascular disease; metabolic syndrome; diabetes mellitus; cancer; neurodegenerative disease; gut microbiome

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Bioactive Antioxidants: Structural Characterization, Synthetic Pathways, and Clinical Applications

edited by

Jolanta Flieger

submission deadline 30 Nov 2025 | 1 articles | Viewed by 746 | Submission Open

Keywords: bioactive antioxidants; therapeutic potential; synthetic strategies; structural characterization

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Oxidative Metabolism and Mitochondrial Dysfunction in Metabolic Diseases—3rd Edition

edited by

Gina Cavaliere

and

Giovanna Trinchese

submission deadline 30 Nov 2025 | Viewed by 285 | Submission Open

Keywords: mitochondria function; oxidative processes; metabolic diseases; reactive oxygen species; therapeutic approaches; mitochondrial integrity; energy production; mitochondrial bioenergetic; metabolism; mitochondrial dynamic

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Lipid Peroxidation, Vegetable Oil Oxidation, and the Role of Plant Extracts in Enhancing Oxidative Stability

edited by

Daniele Sanna

and

Angela Fadda

submission deadline 30 Nov 2025 | Viewed by 250 | Submission Open

Keywords: oil oxidative stability; natural antioxidants; lipid peroxidation; surfactants; encapsulation

(This special issue belongs to the Section Aberrant Oxidation of Biomolecules)

Advances in Mitochondrial Redox Biology—Second Edition

edited by

Masuko Ushio-Fukai

submission deadline 30 Nov 2025 | Viewed by 248 | Submission Open

Keywords: mitochondria; redox signaling; reactive oxygen species (ROS); mitochondrial dynamics; bioenergetics; mitochondria– nuclear communication; aging; cell metabolism

Natural Products to Mitigate Oxidative Stress and Inflammation in Non-Communicable Intestinal Diseases

edited by

Carlos Martins-Gomes

and

Amélia M. Silva

submission deadline 30 Nov 2025 | Viewed by 236 | Submission Open

Keywords: natural bioactives; phytochemicals; oxidative stress; inflammation; non-communicable intestinal diseases; colorectal cancer; inflammatory bowel diseases; signalling pathways

Oxidative Stress in Pregnant Women and Fetuses

edited by

Javier Diaz-Castro

Julio J. Ochoa Herrera

and

Jorge Moreno-Fernandez

submission deadline 30 Nov 2025 | Viewed by 228 | Submission Open

Keywords: metabolic programming; oxidative stress; antioxidants; mitochondria; inflammatory signaling; reactive oxygen species; reactive nitrogen species; placenta; trace elements; nutrition; gestation; offspring; pregnancy; breastfeeding; fetus

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Role of Oxidative Stress in Age-Related and Degenerative Eye Diseases

edited by

Ting Zhang

submission deadline 30 Nov 2025 | Viewed by 218 | Submission Open

Keywords: oxidative stress; age-related macular degeneration; retinal degeneration; reactive oxygen species; redox signaling; mitochondrial dysfunction; antioxidant therapy; artificial intelligence; multi-omics; biomarkers; vision science

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Methodologies for Improving Antioxidant Properties and Absorption, 2nd Edition

edited by

Daniela Tofani

submission deadline 30 Nov 2025 | Viewed by 183 | Submission Open

Keywords: bioavailability; targeted absorption; delivery systems; antioxidant structural modification; structure– activity relationship

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Artificial Intelligence and Other Bioinformatic Modern Technologies Approaches to the Study of Antioxidant Capacity in Food Production

edited by

Giuseppe Perretti

submission deadline 5 Dec 2025 | Viewed by 523 | Submission Open

Keywords: artificial intelligence; bioinformatics; food processing; food quality; antioxidant capacity; big data

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

The Role of Oxidative Stress in Environmental Toxicity—2nd Edition

edited by Hariz Islas Flores

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1745 | Submission Open

Keywords: environmental pollutants; oxidative stress biomarkers; water/air/soil pollution; environmental toxicity; ROS and RNS

Phenolics as Antioxidant Agents—2nd Edition

edited by

Alfredo Aires

submission deadline 10 Dec 2025 | Viewed by 142 | Submission Open

Keywords: antioxidants; bioactive compounds; oxidative stress; structure– activity relationships (SARs); sustainable extraction; green chemistry; therapeutic potential; in vitro and in vivo models; food and biomedical applications

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Redox Regulation in Algae

edited by

Kim Gwang Hoon

submission deadline 10 Dec 2025 | Viewed by 87 | Submission Open

Keywords: algae; reactive oxygen species; redox regulation; stress responses; NADPH oxidases; antioxidants; redox-sensitive transcription factors

(This special issue belongs to the Section ROS, RNS and RSS)

Applications of Antioxidant Nanoparticles, 2nd Edition

edited by

Rita Cortesi

and

Maddalena Sguizzato

submission deadline 15 Dec 2025 | 8 articles | Viewed by 19484 | Submission Open

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Harnessing Antioxidants: Pioneering Approaches in Cardiovascular Disease Prevention and Therapy

edited by

Lanrong Bi

and

Guim Kwon

submission deadline 15 Dec 2025 | 1 articles | Viewed by 2638 | Submission Open

Keywords: oxidative stress; reactive oxygen species (ROS); antioxidants; cardiovascular diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Phytochemical Analysis and Evaluation of Antioxidant Properties in Medicinal Plants

edited by

Magdalena Jeszka-Skowron

Agnieszka Zgoła-Grześkowiak

Tomasz Grześkowiak

and

Robert Frankowski

submission deadline 20 Dec 2025 | 7 articles | Viewed by 20583 | Submission Open

Keywords: antioxidant activity; phytochemicals in plants; medicinal plants; extraction; in vivo analysis; in vitro analysis

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidant and Anti-Inflammatory Properties of Mushrooms: From Structure to Functionality

edited by

Michał Swieca

submission deadline 20 Dec 2025 | 3 articles | Viewed by 11045 | Submission Open

Keywords: mushroom; antioxidants; metabolic syndrome; functional food; nutraceuticals; polysaccharides; phenolics; terpenoids

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Interplay of Microbiome and Oxidative Stress

edited by

Julio Plaza-Díaz

Lourdes Herrera-Quintana

and

Héctor Vázquez Lorente

submission deadline 20 Dec 2025 | 3 articles | Viewed by 11005 | Submission Open

Keywords: microbiome; oxidative stress; antioxidants; gut microbiota; free radicals; reactive oxygen species; gut– brain axis; dysbiosis; microbial metabolites; mitochondrial function; probiotics; microbe– host interactions

The Use of Antioxidant-Rich Foods and Supplements in Disease Prevention

edited by

Abraham Wall Medrano

Escobar-Puentes Alberto A.

and

Gustavo Adolfo González-Águilar

submission deadline 20 Dec 2025 | 3 articles | Viewed by 9153 | Submission Open

Keywords: dietary antioxidants; bioactivity; metabolomics; human diet; xenobiotics; polyphenols; vitamins; health promotion

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in Plant Redox Biology Research

edited by Yurong Xie and Ming Chang

submission deadline 20 Dec 2025 | Viewed by 228 | Submission Open

Keywords: plant redox biology; reactive oxygen species; reactive nitrogen species; plant development; environmental stress; abiotic/biotic stresses; host– microbe interactions

(This special issue belongs to the Section ROS, RNS and RSS)

Significance of Antioxidant Mechanisms in Intestinal Inflammation—2nd Edition

edited by

Alba Rodríguez-Nogales

and

María Elena Rodríguez Cabezas

submission deadline 20 Dec 2025 | Viewed by 176 | Submission Open

Keywords: antioxidant therapy; antioxidants; intestinal inflammation; oxidative stress; polyphenol; reactive oxygen/nitrogen species; redox homeostasis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants as Adjuvants for Inflammatory Bowel Disease Treatment

edited by

Marcello Chieppa

and

Angelo Santino

submission deadline 22 Dec 2025 | 4 articles | Viewed by 8458 | Submission Open

Keywords: IBD; antioxidant; gut barrier; inflammation; natural compounds; microbiome; colon cancer; adjuvant; nutritional bioactive products; polyphenols

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Hydrogen and Oxidative Stress: Implications for Health and Longevity

edited by

Kyu-Jae Lee

and

Cheol-Su Kim

submission deadline 25 Dec 2025 | 1 articles | Viewed by 1435 | Submission Open

Keywords: molecular hydrogen (H2); oxidative stress; redox homeostasis; selective antioxidant; reactive oxygen species (ROS); aging and longevity; mitochondrial protection; cellular resilience; hydrogen therapy; inflammation and immunity; neurodegeneration; cardiovascular health; metabolic disorders; gene regulation; translational medicine; longevity

(This special issue belongs to the Section ROS, RNS and RSS)

Nitric Oxide and Redox Mechanisms

edited by

Massimiliano Coletta

, Paolo Ascenzi and

Giovanna De Simone

submission deadline 30 Dec 2025 | 6 articles | Viewed by 13004 | Submission Open

Keywords: nitric oxide; ROS and RNS; nitrosative stress; NO signaling; redox mechanisms

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidant Response in Aquatic Animals

edited by Martha Gabriela Gaxiola-Cortes

submission deadline 30 Dec 2025 | 8 articles | Viewed by 11066 | Submission Open

Keywords: antioxidant system; respiration; nutrition; culture; fish; aquatic animals; reactive oxygen species (ROS); superoxide dismutase (SOD)

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