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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antioxidant Research in Chile—2nd Edition

edited by

Rodrigo Iturriaga

and

Hugo Diaz

submission deadline 30 May 2026 | 12 articles | Viewed by 20257 | Submission Open

Keywords: antioxidants; biotechnology; biomedicine; natural products; nutrition; oxidative stress; Chilean plants of economic importance; polyphenols; flavonoids; anthocyanins; phenolic acids; resveratrol; food waste; plant extracts; neuroinflammation; redox signaling; circular economy; ROS scavengers; antioxidants in industry; entrepreneurship; green startups

Oxidative Stress in Livestock and Poultry—3rd Edition

edited by

Wutai Guan

and

Shihai Zhang

submission deadline 30 May 2026 | 6 articles | Viewed by 13865 | Submission Open

Keywords: oxidative stress; environmental stressors; gut microbiome; antioxidant strategies; epigenetic modifications

Oxidative Stress in Plant Stress and Plant Physiology

edited by

Mohsin Tanveer

submission deadline 30 May 2026 | 4 articles | Viewed by 5207 | Submission Open

Keywords: ROS signaling; stress adaptive responses; halophyte vs glycophyte; redox homeostasis; molecular crosstalk with ROS signaling; biotic; abiotic; soil borne; and air pollutants

(This special issue belongs to the Section ROS, RNS and RSS)

Glutathione Redox Cycle, 2nd Edition

edited by

Alessio Bocedi

submission deadline 30 May 2026 | Viewed by 415 | Submission Open

Keywords: glutathione; oxidized glutathione; glutathione metabolism; glutathione biosynthesis; glutathione homeostasis; thiol redox status; disulfide; GSH; GSSG

(This special issue belongs to the Section Antioxidant Enzyme Systems)

The OxInflammation Process and Tissue Repair

edited by Reggiani Vilela Gonçalves, Mariaurea Matias Sarandy and Rômulo Dias Novaes

submission deadline 31 May 2026 | 6 articles | Viewed by 27713 | Submission Open

Keywords: oxidative stress; inflammasome; cytokines; angiogenesis; molecular biology; cellular and molecular mechanisms; diabetes; tissue repair

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Multi-Target Profile of Antioxidant Compounds, Including Repurposing and Combination Strategies—2nd Edition

edited by

Roberta Rocca

submission deadline 31 May 2026 | 5 articles | Viewed by 16358 | Submission Open

Keywords: polypharmacology; multi-target ligands; rational drug; design repurposing; off-target effects; computational techniques

Lipid Peroxidation in Physiology and Chronic Inflammatory Diseases

edited by

Mario Di Gioacchino

submission deadline 31 May 2026 | 2 articles | Viewed by 12001 | Submission Open

Keywords: lipid peroxidation; oxidative stress; chronic inflammation; antioxidants; reactive lipid species; inflammatory signaling; redox biology; lipid mediators; disease pathogenesis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Hepatic Diseases

edited by

Miquel Mulero

submission deadline 31 May 2026 | 5 articles | Viewed by 11724 | Submission Open

Keywords: oxidative stress; hepatic diseases; liver fibrosis; reactive oxygen species (ROS); mitochondrial dysfunction; lipid peroxidation; antioxidant defense; non-alcoholic fatty liver disease (NAFLD); alcoholic liver disease; hepatoprotective strategies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Animal Reproduction and Nutrition

edited by

Fang Chen

and

Jun Chen

submission deadline 31 May 2026 | 9 articles | Viewed by 11506 | Submission Open

Keywords: oxidative stress; antioxidants; animal reproduction; nutritional regulation; livestock and poultry; mouse or rat model; antioxidant mechanisms; oxidative stress mechanisms

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Plants and Plant-Based By-Products as Valuable Sources of Antioxidants: Current Tendencies and Achievements in Their Exploitation

edited by Svetlana Momchilova and

Adriana Slavova-Kazakova

submission deadline 31 May 2026 | 7 articles | Viewed by 11179 | Submission Open

Keywords: antioxidants; oxidative stability; antioxidant activity; lipid oxidation; green chemistry; biomass; plants and by-products; herbs; utilization

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Roles of NADPH Oxidase in Modulation of Signal Transduction and Cellular Metabolism—2nd Edition

edited by

Rosario Ammendola

and

Fabio Cattaneo

submission deadline 31 May 2026 | 5 articles | Viewed by 10572 | Submission Open

Keywords: redox signaling; inflammation; NADPH oxidase; ROS; cell metabolism; redox-state; Warburg effect; metabolic reprogramming; tumor microenvironment; cell proliferation

(This special issue belongs to the Section Antioxidant Enzyme Systems)

Innovative Technologies for Detecting Antioxidant Properties and Oxidative Stabilization of Agri-Food Products and Plant Extracts

edited by

Chao Hui Feng

submission deadline 31 May 2026 | 3 articles | Viewed by 10506 | Submission Open

Keywords: green extraction; plant extracts; bioactive compounds; flavonoids; polyphenols; detection technologies; antioxidant activity

(This special issue belongs to the Section Methods for Antioxidants Evaluation/Measurement)

Bioactive Compounds from Natural Sources with Antioxidant and Anti-Inflammatory Potential

edited by

Chun Guang Li

submission deadline 31 May 2026 | 8 articles | Viewed by 10423 | Submission Open

Keywords: antioxidant; anti-inflammatory; natural compounds; isolation; extraction; molecular mechanism; synergistic effect; clinical trial; bioavailability; analytical method; pharmacodynamics; pharmacokinetics

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Cellular ROS and Antioxidants: Physiological and Pathological Role—2nd Edition

edited by

Andrey V. Kozlov

Mihály Boros

and

Salvatore Nesci

submission deadline 31 May 2026 | 5 articles | Viewed by 9782 | Submission Open

Keywords: reactive oxygen and nitrogen species; intracellular signaling; oxidative stress; iron metabolism; mitochondrial dysfunction; hypoxia; inflammation; targeted and untargeted antioxidants; gas messengers natural and artificial sources of reactive oxygen species; antioxidant defense systems; small signaling molecules; oxidative stress-driven processes

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Age-Related Diseases

edited by

Gloria Olaso-Gonzalez

submission deadline 31 May 2026 | 3 articles | Viewed by 7451 | Submission Open

Keywords: aging; age-related diseases; frailty; oxidative stress; reductive stress; redox homeostasis; antioxidants

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress Mechanisms and Parkinson's Disease Treatment

edited by

Juan Segura-Aguilar

submission deadline 31 May 2026 | 2 articles | Viewed by 5289 | Submission Open

Keywords: Parkinson’ s disease; dopamine; dopamine oxidation; neuromelanin; dopaminergic neurons; antioxidants; neuroprotection; neurodegeneration; oxidative stress; protein degradation dysfunction; neuroinflammation; mitochondrial dysfunction; endoplasmic reticulum stress; alpha-synuclein oligomers; glutathione; glutathione transferase; DT-diaphorase; preclinical model for Parkinson's disease; VMAT2; dopamine transporter; tyrosine hydroxylase; dopamine-derived orto-quinones

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and NRF2 in Diabetes

edited by

R. Paul Robertson

submission deadline 31 May 2026 | 2 articles | Viewed by 4587 | Submission Open

Keywords: oxidative stress; NRF2; ROS; diabetes; diabetes-related complications; insulin

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress During Physical Activity

edited by

Ivan Dimauro

submission deadline 31 May 2026 | 2 articles | Viewed by 3759 | Submission Open

Keywords: physical activity; exercise; oxidative stress; reactive oxygen species (ROS); redox balance; cellular damage; skeletal muscle

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Role of Oxidative Stress in Cardiac Remodeling and Heart Failure—3rd Edition

edited by

Marina Politi Okoshi

Elida Paula Benquique Ojopi

and

Luana Urbano Pagan

submission deadline 31 May 2026 | 2 articles | Viewed by 3447 | Submission Open

Keywords: oxidative stress; heart disease; cardiac remodeling; signaling pathways; remodeling; left ventricular dysfunction; heart failure; cardiovascular disease; myocardial damage

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Hydrogen Sulfide, Reactive Sulfur Species, and Donor Compounds: Natural and Synthetic Tools for Physiology and Disease

edited by

Giuseppe Caliendo

and

Angela Corvino

submission deadline 31 May 2026 | 2 articles | Viewed by 3114 | Submission Open

Keywords: hydrogen sulfide; H2S donors; H2S hybrid compounds; H2S sources; pharmacological tools; H2S signaling

Oxidative Stress as a Therapeutic Target of Alzheimer’s Disease—2nd Edition

edited by

Leonardo Brunetti

and

Marcello Leopoldo

submission deadline 31 May 2026 | 2 articles | Viewed by 2739 | Submission Open

Keywords: Alzheimer's disease; oxidative stress; therapeutic target; antioxidant; neurodegeneration

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection—3rd Edition

edited by

Maja Jazvinšćak Jembrek

and

Josipa Vlainić

submission deadline 31 May 2026 | 2 articles | Viewed by 2277 | Submission Open

Keywords: neuroprotection; neurotoxicity; antioxidative vs. prooxidative activity; antioxidant capacity; signaling pathways; redox metals; apoptosis; ferroptosis; cuproptosis; autophagy

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Vitamins, Antioxidants, and Neurodegeneration: Exploring Protective Strategies in Brain Health

edited by

Maria Morello

submission deadline 31 May 2026 | 2 articles | Viewed by 1814 | Submission Open

Keywords: neurodegenerative diseases; alzheimer's disease; parkinson's disease; amyotrophic lateral sclerosis (ALS); aging populations; vitamins; antioxidants; oxidative stress; neuroinflammation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Mitochondrial Dysfunction and Oxidative Stress in Aging and Age-Related Disorders

edited by

Dharendra Thapa

submission deadline 31 May 2026 | 1 articles | Viewed by 1759 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; aging; age-related diseases; mitochondrial biogenesis; reactive oxygen species (ROS); mitochondrial quality control; redox homeostasis; cellular senescence; neurodegeneration

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Cancers of the Female Reproductive Tract: Bridging Current Knowledge with New Technologies

edited by Ioannis A. Kalogiannidis and

Areti Kourti

submission deadline 31 May 2026 | 1 articles | Viewed by 1649 | Submission Open

Keywords: oxidative stress; female reproductive cancers; reactive oxygen species (ROS); antioxidant mechanisms; therapeutic target

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Regulation of Cancer Metabolism

edited by

Marta Menegazzi

, Adriana Celesia and Alessia Cardile

submission deadline 31 May 2026 | 1 articles | Viewed by 1605 | Submission Open

Keywords: redox homeostasis; cancer metabolism; reactive oxygen species (ROS); metabolic reprogramming; oxidative stress; Nrf2; HIF-1α ; mitochondrial metabolism; antioxidant therapy; metabolic vulnerabilities

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Precision Medicine in Cardiometabolic and Cardiovascular Disease: Mechanisms, Biomarkers, and Therapeutic Targets

edited by Leroy Sivappiragasam Pakkiri and Chester Lee Drum

submission deadline 31 May 2026 | 1 articles | Viewed by 1417 | Submission Open

Keywords: oxidative stress; precision medicine; cardiometabolic disease; cardiovascular disease; redox signaling

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Effects of Antioxidants as Supplements on Exercise Performance and Recovery

edited by

Sabrina Donati Zeppa

and Rossella Rotondo

submission deadline 31 May 2026 | 1 articles | Viewed by 1347 | Submission Open

Keywords: exercise performance; exercise recovery; oxidative stress; antioxidants; sport nutrition; sport supplements; detoxification systems

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant and Antimicrobial Activity of Honey Bee Products—3rd Edition

edited by

Ivana Tlak Gajger

and

Josipa Vlainić

submission deadline 31 May 2026 | 1 articles | Viewed by 1311 | Submission Open

Keywords: honey bee products; antioxidant capacity; antimicrobial efficacy; polyphenol content; functional food; health promotion

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Oxidative Stress in Cancers

edited by

Jessica Ruzzolini

and

Silvia Peppicelli

submission deadline 31 May 2026 | 2 articles | Viewed by 897 | Submission Open

Keywords: cancer; oxidative stress; ROS; antioxidants; combined therapy; cellular death

Antioxidant Activities of Nanomaterials: Mechanisms, Applications, and Technological Potential

edited by

Luciano Paulino Silva

submission deadline 31 May 2026 | 1 articles | Viewed by 811 | Submission Open

Keywords: antioxidant nanomaterials; nano-antioxidants; oxidative Stress; free radical scavenging; nanomedicine

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidant Properties and Applications of Food By-Products—2nd Edition

edited by

Kai Wang

submission deadline 31 May 2026 | 1 articles | Viewed by 587 | Submission Open

Keywords: food by-products ; nutrients ; extracts ; bioactive compounds ; antioxidant activity ; physiochemical properties ; functional food; value-added application

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Anti-Cancer Potential of Plant-Based Antioxidants—2nd Edition

edited by

Javier Espino

María Garrido

and

Jonathan Delgado-Adamez

submission deadline 31 May 2026 | 1 articles | Viewed by 563 | Submission Open

Keywords: antioxidants; cancer; carotenoids; medicinal plants; nutraceuticals; oxidative stress; polyphenols; terpenoids

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Neuroinflammation in Alzheimer’s Disease: Molecular Mechanisms and Therapeutic

edited by

Seung-Hoon Yang

submission deadline 31 May 2026 | Viewed by 325 | Submission Open

Keywords: Alzheimer’ s Disease; oxidative stress; neuroinflammation; antioxidants; amyloid beta; tau pathology; mitochondrial dysfunction; micoglia activation; cell death regulation; therapeutic natural products

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in Analysis of Antioxidant-Rich Medicinal Plants, Functional Foods and Food Supplements

edited by

Audrius Maruška

and

Vilma Kaškonienė

submission deadline 31 May 2026 | Viewed by 242 | Submission Open

Keywords: antioxidants; bioactive compounds; extraction; medicinal plants; natural products; instrumental analysis; chromatography; spectrometry; biological activity; chemometrics; structure– activity relationship

(This special issue belongs to the Section Methods for Antioxidants Evaluation/Measurement)

Antioxidant Role of High-Density Lipoprotein—2nd Edition

edited by Paul Durrington

submission deadline 31 May 2026 | Viewed by 208 | Submission Open

Keywords: lipoprotein oxidation; cell membrane oxidation; HDL antioxidant activity; glycosylation; atherosclerosis; paraoxonase

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in Oxidative Stability of Foods

edited by

Carlos F. Torres

submission deadline 31 May 2026 | Viewed by 199 | Submission Open

Keywords: food chemistry; oxidative stability; food processing; food storage; food engineering; antioxidants; food science

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidant Peptides from Marine Organisms: Structural Insights, Functional Mechanisms, and Sustainable Applications

edited by Changfeng Chi

submission deadline 1 Jun 2026 | 1 articles | Viewed by 2882 | Submission Open

Keywords: marine peptides; antioxidant activity; structure identification; structural modification; bioactivity and function; structure; function relationship; functional foods; biodiversity; organismic diversity and diversity preservation; genetic diversity

Oxidative Stress in Lung Diseases

edited by

Rudolf Lucas

submission deadline 15 Jun 2026 | 4 articles | Viewed by 16508 | Submission Open

Keywords: ROS; RNS; lung diseases; antioxidant defense; respiratory health

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Activity of Polyphenolic Extracts

edited by

Dimitrios Stagos

submission deadline 15 Jun 2026 | 5 articles | Viewed by 10937 | Submission Open

Keywords: antioxidant activity; polyphenols; plant extracts; oxidative stress

Oxidative Stress in Pregnant Women and Fetuses

edited by

Javier Diaz-Castro

Julio J. Ochoa Herrera

and

Jorge Moreno-Fernandez

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1992 | Submission Open

Keywords: metabolic programming; oxidative stress; antioxidants; mitochondria; inflammatory signaling; reactive oxygen species; reactive nitrogen species; placenta; trace elements; nutrition; gestation; offspring; pregnancy; breastfeeding; fetus

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Hormonal and Redox Regulation in Cancer, Metabolic Dysfunction, and Neurodegenerative Diseases

edited by

Moon Nyeo Park

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1229 | Submission Open

Keywords: hormonal regulation; redox signaling; antioxidant hormones; melatonin; oxidative stress; mitochondria; epigenetics; noncoding RNA; metabolic reprogramming; ferroptosis; inflammation; SIRT1/AMPK; Nrf2/Keap1; redox therapeutics; translational pharmacology; natural compounds

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Directed Lipid Oxygenation as an Antioxidant System

edited by Cecil Pace-Asciak

submission deadline 25 Jun 2026 | Viewed by 210 | Submission Open

Keywords: COX/LOX; phospholipases; mono; di and tri HPETES/HETES; ROS; antioxidants; second messengers; biological actions; pathology; therapeutics

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidants and Retinal Diseases—2nd Edition

edited by

Francisco J. Romero

and Jorge M. Barcia

submission deadline 30 Jun 2026 | 9 articles | Viewed by 51365 | Submission Open

Keywords: retinal diseases; antioxidants; oxygen species; extracellular vesicles; miRNA

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Janus Face of Oxidative Stress in Normal and Pathological Conditions

edited by

Marco Fiore

submission deadline 30 Jun 2026 | 13 articles | Viewed by 36100 | Submission Open

Keywords: ethanol; toxicity; abuse; addiction; binge drinking; oxidative stress; psychoactive drug; cancer; recreational drug; FASD

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Free Radicals, Antioxidants, and Oxidative Stress in Aging and Age-Related Diseases—2nd Edition

edited by

Abdelouahed Khalil

and

Tamas Fulop

submission deadline 30 Jun 2026 | 6 articles | Viewed by 30504 | Submission Open

Keywords: aging; oxidative stress; age-related diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Implication of Oxidative Stress in Promoting Cellular Senescence and Associated Pathologies—2nd Edition

edited by

Alexandra Barbouti

submission deadline 30 Jun 2026 | 9 articles | Viewed by 28983 | Submission Open

Keywords: oxidative stress; free radicals; reactive oxygen species (ROS); cellular senescence; ageing; age-related pathologies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

From Waste to Health: Upcycling Agrifood By-Products into Functional Antioxidant-Rich Ingredients and Products

edited by

Ítala Maria Gouveia Marx

and

Feliciano Priego-Capote

submission deadline 30 Jun 2026 | 6 articles | Viewed by 17006 | Submission Open

Keywords: antioxidant activity; oxidative stress; reactive oxygen species; polyphenols; bioactive compounds; functional ingredients; health-promoting formulations; agrifood waste; green extraction technologies; emerging analytical methods

Developmental Origins of Health and Disease: Antioxidants as Strategy for Prevention and Treatment

edited by

Silvia M. Arribas

and

David Ramiro-Cortijo

submission deadline 30 Jun 2026 | 6 articles | Viewed by 15632 | Submission Open

Keywords: oxidative stress; pregnancy; germline damage; obstetric complications; fetal programming

Oxidative Stress in Cell Senescence

edited by

Sara Cruciani

submission deadline 30 Jun 2026 | 7 articles | Viewed by 14870 | Submission Open

Keywords: stem cells; cell senescence; regenerative medicine; antioxidant strategies; age-related diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

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