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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Alcohol-Induced Oxidative Stress in Health and Disease, 2nd Edition

edited by

Marco Fiore

submission deadline 10 Apr 2026 | 7 articles | Viewed by 13974 | Submission Open

Keywords: alcohol; alcohol use disorder; reactive oxygen species; antioxidant defense

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Biology of Glyoxalases and Advanced Glycation End Products in Health and Diseases

edited by

Cinzia Antognelli

Marilena Pariano

and

Vincenzo Nicola Talesa

submission deadline 10 Apr 2026 | 7 articles | Viewed by 11158 | Submission Open

Keywords: glyoxalases; methylglyoxal; advanced glycation end products; aging; diseases; antioxidants; apoptosis; cell proliferation; nutraceuticals; oxidative stress; inflammation; apoptosis; EMT; cell proliferation; signal transduction; biological mechanisms

(This special issue belongs to the Section Antioxidant Enzyme Systems)

Reactive Nitrogen Species (RNS) and Redox Signaling in Tumors

edited by Maria Clara Franco and

Luciana Hannibal

submission deadline 10 Apr 2026 | 1 articles | Viewed by 7916 | Submission Open

Keywords: tumor biology; reactive nitrogen species; redox signaling; oxidative stress; ROS

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants for Cosmetic Applications

edited by

Rita Cortesi

and

Maddalena Sguizzato

submission deadline 10 Apr 2026 | 3 articles | Viewed by 3846 | Submission Open

Keywords: cosmetic formulations; skin care; oxidative stress; photoprotection

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Antioxidants and Metabolic Diseases, 2nd Edition

edited by

José Ángel Rufián-Henares

Fortuna Iannuzzo

Elisabetta Schiano

and

Maria Maisto

submission deadline 10 Apr 2026 | 2 articles | Viewed by 2212 | Submission Open

Keywords: metabolic syndrome; antioxidant compounds; diabetes; obesity; cardiovascular diseases; biological effects; food sources; medicinal plants; oxidative stress; inflammation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Synthetic Compounds: Antioxidant and Anti-Inflammatory Activities, Biomedical Properties and Formulations

edited by

Simone Carradori

and

Ilaria D'Agostino

submission deadline 20 Apr 2026 | 5 articles | Viewed by 11457 | Submission Open

Keywords: antioxidants; inflammation pathways; therapeutic activity; redox potential; synthesis; preclinical studies; macrophages; immunomodulation; packaging; formulations; topical application; polymers; nanotechnology; cytotoxicity; mechanism of action; food; drug design

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Novel Antioxidant Mechanisms for Health and Diseases, 2nd Edition

edited by Yoshihisa Koyama

submission deadline 20 Apr 2026 | 4 articles | Viewed by 8285 | Submission Open

Keywords: antioxidant therapy; reactive oxygen species; oxidative stress; nano-antioxidant therapy; nutrigenomics; microbiome

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress, Mitochondrial Dysfunction, and Inflammation in Autism

edited by

Abha Chauhan

submission deadline 20 Apr 2026 | Viewed by 471 | Submission Open

Keywords: autism; oxidative stress; mitochondria; inflammation; redox signaling; antioxidants; reactive oxygen species; immune response

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Role of Natural Antioxidants on Neuroprotection

edited by

Mercedes Villacampa

José Carlos Menéndez

and

Ángel Cores

submission deadline 30 Apr 2026 | 6 articles | Viewed by 30459 | Submission Open

Keywords: drug design; polyphenols; oxidative stress; Nrf2 induction; neuroinflammation; neurodegenerative diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Lysosomal Function in Health and Disease

edited by

Silvana M. Zanlungo

and Alejandra R. Álvarez

submission deadline 30 Apr 2026 | 4 articles | Viewed by 18211 | Submission Open

Keywords: lysosome; lysosomal dysfunction; lysosome homeostasis; autophagy; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Activities of Phytochemicals in Fruits and Vegetables

edited by

Wen Qin

submission deadline 30 Apr 2026 | 5 articles | Viewed by 10058 | Submission Open

Keywords: ROS and oxidative stress; green and efficient extraction technology of phytochemicals; antioxidant activity of phytochemicals in fruits and vegetables; polyphenols and polysaccharides in fruits and vegetables; phytochemicals and inflammation

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress from Environmental Exposures

edited by

Giulia Squillacioti

Valeria Bellisario

and

Federica Ghelli

submission deadline 30 Apr 2026 | 2 articles | Viewed by 6131 | Submission Open

Keywords: environmental exposures; human health; air pollution; lifestyle; oxidative stress; particulate matter; environmental stressors

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Signaling in Brain Aging and Neurodegeneration

edited by Marco Bisaglia

submission deadline 30 Apr 2026 | 3 articles | Viewed by 5259 | Submission Open

Keywords: aging; autophagy; brain; Alzheimer disease; amyotrophic lateral sclerosis; Friedreich ataxia; Huntington disease; neurodegeneration; oxidative stress; protein aggregation; Parkinson’ s disease; reactive oxygen species

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Resilience Signaling of Functional Nutrients and Neurotoxicant Pollutants for Human Health

edited by

Maria Scuto

and

Angela Trovato Salinaro

submission deadline 30 Apr 2026 | 2 articles | Viewed by 4612 | Submission Open

Keywords: dietary nutrients; polyphenol-basaed nanoparticles; oxidative stress; apoptosis; ferroptosis; pyroptosis; hormesis; inflammation; human health; toxicant pollutants; apoptosis; cancer; nervous system disorders; personalized nutritional therapy

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants in Cardiovascular Medicine: Emerging Trends and Future Perspectives

edited by

Matteo Becatti

and

Claudia Fiorillo

submission deadline 30 Apr 2026 | 4 articles | Viewed by 4436 | Submission Open

Keywords: cardiovascular disease; CVD; atherosclerosis; hypertension; heart failure; ischemic heart disease; vascular aging; myocardial remodeling

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Based on Antioxidant Capacity: The Multifunctional Roles of Bioactive Compounds from Fruits and Vegetables in Precision Nutrition

edited by

Mauro Lombardo

submission deadline 30 Apr 2026 | 2 articles | Viewed by 4436 | Submission Open

Keywords: fruits and vegetables; antioxidants; anti-inflammatory; plant compounds; health

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Sperm: Technical, Biological and Clinical Aspects—2nd Edition

edited by

Monica Muratori

submission deadline 30 Apr 2026 | 4 articles | Viewed by 4023 | Submission Open

Keywords: male infertility; ROS; oxidative sperm DNA damage; sperm DNA fragmentation; sperm epigenetic damage; assisted reproductive techniques; in vitro sperm manipulation; antioxidants; embryo development; pregnancy

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

High-Fat Diet-Induced Oxidative Stress

edited by

María Teresa Llinas Más

and

Isabel Hernández

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3783 | Submission Open

Keywords: saturated fats; fats; high-fat diet; obesity; cardiovascular disease; non-alcoholic fatty liver disease; oxidative stress; antioxidants; cancer; neurodegenerative diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Radiation Exposure and Health: The Role of Oxidative Stress and Inflammatory Response

edited by

Siamak Haghdoost

and

Benjamin Frey

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3677 | Submission Open

Keywords: radiation; inflammatory response; oxidative stress

Oxidative Stress in Striated Muscle and Other Tissues

edited by

Enrique Jaimovich

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3423 | Submission Open

Keywords: ROS/RNS production; mitochondria ROS; NADPH oxidase; metabolic regulation; cardiac oxidative stress; ROS sources; exercise-induced ROS/RNS; antioxidants; ROS/RNS in disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Nrf2 and Cardiovascular Function, Diseases, and Therapeutic Targets

edited by

Gao Lie

and

Irving H. Zucker

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2943 | Submission Open

Keywords: nuclear factor erythroid 2-related factor 2 (Nrf2); Nrf2-targeted therapies; cardiovascular diseases; antioxidant; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants from Sustainable Food Sources—2nd Edition

edited by

Kevin Kantono

and

Nazimah Hamid

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2871 | Submission Open

Keywords: sustainable antioxidants; natural sources; green extraction; functional foods; food system resilience

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress in Hearing Loss—2nd Edition

edited by Lei Song and Joseph Santos-Sacchi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2365 | Submission Open

Keywords: ear; outer hair cell; inner ear

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Skin Disorders: Therapeutic Potential of Antioxidants

edited by

Hideya Ando

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1778 | Submission Open

Keywords: ultraviolet radiation; reactive oxygen species; oxidative stress; skin disorders; skin aging

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Mitochondria, Redox and Pancreatic β-Cells: Maturation, Function and Inflammatory Stress

edited by Sarah Zangen

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1501 | Submission Open

Keywords: pancreatic β -cell mitochondria; redox; ETC dysfunction; electron ROS/RNS; mitophagy; UPR^mt; antioxidant defenses; cytokines; inflammasome; iPSC/islet organoids; biomarkers; therapeutics

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Innovative Approaches to Antioxidant Activity and Polyphenol Extraction

edited by José Ricardo Pérez-Correa and

María Salomé Mariotti-Celis

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1272 | Submission Open

Keywords: polyphenols; novel antioxidant activity methods; sustainable separation technologies; innovative application techniques

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Phenolic Profiling and Antioxidant Capacity of Natural Products

edited by

María Jesús Rodríguez-Yoldi

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1167 | Submission Open

Keywords: plant extracts; antioxidant capacity; phenolic profiling; stress oxidative diseases

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Phytotherapy and Natural Products in the Treatment and Prevention of Chronic Diseases

edited by

Sara Damiano

and

Roberto Ciarcia

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1003 | Submission Open

Keywords: chronic diseases; phytotherapy; natural antioxidants; plant-derived compounds

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidant Activity of Natural Bioactive Compounds in Food and Agricultural Byproducts

edited by

Fabiana Pizzolongo

and

Filosa Stefania

submission deadline 30 Apr 2026 | 1 articles | Viewed by 910 | Submission Open

Keywords: waste valorization; phytochemicals; functional ingredients; green extraction; nutritional enhancement; circular economy; health-promoting compounds; food fortification; shelf-life extension; oxidative stress

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Innovative Processing Technologies and Their Effects on Antioxidant Activity in Plant-Derived Natural Products

edited by

Filipa Mandim

submission deadline 30 Apr 2026 | 1 articles | Viewed by 797 | Submission Open

Keywords: innovative extraction methodologies; natural antioxidants; oxidative stress modulations; cell-based and biochemical assays

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Anti-Inflammatory Agents from Natural Antioxidants: Discovery, Mechanisms, and Therapeutic Potential

edited by

Young-Chang Cho

submission deadline 30 Apr 2026 | 1 articles | Viewed by 664 | Submission Open

Keywords: oxidative stress; inflammatory responses; antioxidant; anti-inflammation; anti-aging; anticancer; natural products

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

NRF2 in Non-Communicable Diseases

edited by

Isabel Lastres-Becker

submission deadline 30 Apr 2026 | Viewed by 644 | Submission Open

Keywords: NRF2; oxidative stress; inflammation; proteostasis; mitochondria; redox homeostasis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Respiratory Diseases—Second Edition

edited by

Sabina Galiniak

and

Stephen M. Black

submission deadline 30 Apr 2026 | Viewed by 478 | Submission Open

Keywords: reactive oxygen species; inflammation; antioxidant therapy; chronic obstructive pulmonary disease; asthma; cystic fibrosis; nitrosative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants in Prevention and Treatment of Diabetes

edited by Karima Zitouni and Kenneth Earle

submission deadline 30 Apr 2026 | Viewed by 253 | Submission Open

Keywords: diabetic vasculopathy; oxidative stress; type 2 diabetes; antioxidant defenses

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Mitochondrial and Redox Signaling in Exercise, Aging, and Metabolic Health

edited by

Jan Jacek Kaczor

and

Mateusz Jakub Karnia

submission deadline 30 Apr 2026 | Viewed by 243 | Submission Open

Keywords: mitochondria; skeletal muscle; exercise; aging; metabolism; oxidative stress; muscle– brain crosstalk; sarcopenia; osteoporosis; neurodegenerative diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants Isolation and Characterization

edited by José Luis Todolí Torró and

Ana Beltrán Sanahuja

submission deadline 30 Apr 2026 | 1 articles | Viewed by 229 | Submission Open

Keywords: plant-derived antioxidants; polyphenols; flavonoids; carotenoids; phenolic acids; green extraction techniques; chromatographic and spectroscopic analysis; metabolomics; antioxidant activity evaluation; agro-industrial by-products valorization

(This special issue belongs to the Section Methods for Antioxidants Evaluation/Measurement)

Molecular Crosstalk Between Redox Signaling and Intestinal Health: The Role of Dietary Antioxidants

edited by

Carla Gentile

and Graziella Serio

submission deadline 30 Apr 2026 | Viewed by 219 | Submission Open

Keywords: redox signaling; intestinal inflammation; dietary antioxidants; NF-κ B signaling; Nrf2 signaling; epigenetic regulation; tight junctions; polyphenols; melatonin; phytomelatonin

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Role of Antioxidants in Pregnant Women’s and Children’s Health—3rd Edition

edited by

Joanna Gajewska

Jadwiga Ambroszkiewicz

and

Magdalena Chełchowska

submission deadline 30 Apr 2026 | Viewed by 194 | Submission Open

Keywords: antioxidants; oxidative stress; pregnancy; newborns; infants; children; glutathione; adipokines; vitamins; microelements; reproductive health; metabolic disease; lifestyle factors; rare disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advanced in the Protective Action of Antioxidant Signalling Mediators on Skeletal Muscle Regeneration

edited by

Elisabetta Meacci

submission deadline 30 Apr 2026 | Viewed by 194 | Submission Open

Keywords: skeletal muscle (SkM); antioxidant signalling; reactive oxygen species (ROS); muscle stem cells (MuSCs)

Natural Antioxidants from Plants in Combating Metabolism-Related Diseases

edited by

Yue Wang

Chongde Sun

and

Jiebiao Chen

submission deadline 30 Apr 2026 | Viewed by 194 | Submission Open

Keywords: plant-derived antioxidants; flavonoids; alkaloids; coumarins; polysaccharides; metabolism-related diseases; obesity; diabetes; NAFLD; cardiovascular diseases; neurodegenerative diseases; gut microbiota; extraction and purification; bioactivity evaluation; therapeutic applications

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Modulation in Neurodegenerative Disorders: A Focus on Epigenetic Regulation

edited by

Simona Daniele

submission deadline 30 Apr 2026 | Viewed by 168 | Submission Open

Keywords: redox signaling; oxidative stress; epigenetics; DNA methylation; histone modification; chromatin remodeling; noncoding RNA; mitochondrial dysfunction; neurodegeneration; biomarkers

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Peptides

edited by

Daniel Carneiro Moreira

and

José Roberto de Souza de Almeida Leite

submission deadline 10 May 2026 | 5 articles | Viewed by 7866 | Submission Open

Keywords: structure– activity relationships; novel natural or synthetic sources; advanced delivery systems; roles in preventing or alleviating oxidative stress-related diseases.

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Bioactive Antioxidants from Agri-Food Wastes, 2nd Edition

edited by

Mia Kurek

Sabina Galus

and

Tea Sokač Cvetnić

submission deadline 10 May 2026 | 2 articles | Viewed by 1280 | Submission Open

Keywords: agri-food byproducts; waste; food industry; additives; packaging

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Natural Compounds in Neurogenesis, Neurodevelopment, and the Attenuation of Neurotoxicity: Insights from Animal Models

edited by

Giuseppe Montalbano

and

Kamel Mhalhel

submission deadline 10 May 2026 | Viewed by 229 | Submission Open

Keywords: neurogenesis; neurodevelopment; neurotoxicity; antioxidant activity; brain development

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Health Implications of Vitamin E and Its Analogues and Metabolites

edited by Jean-Marc Zingg,

Kiyotaka Nakagawa

and

Taiki Miyazawa

submission deadline 15 May 2026 | 1 articles | Viewed by 3288 | Submission Open

Keywords: vitamin E; antioxidant; non-antioxidant; bioavailability; bioactivity; signalling; gene expression

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Cigarette Smoke and Oxidative Stress

edited by

Lorenzo Loffredo

submission deadline 20 May 2026 | 6 articles | Viewed by 12119 | Submission Open

Keywords: smoking; cardiovascular diseases; oxidative stress; cigarettes

Redox Regulation in COPD: Therapeutic Implications of Antioxidants

edited by

Samuel Santos Valença

submission deadline 20 May 2026 | 2 articles | Viewed by 3571 | Submission Open

Keywords: COPD; oxidative stress; antioxidants; pulmonary diseases; therapeutics

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Phenolics as Antioxidant Agents—2nd Edition

edited by

Alfredo Aires

submission deadline 20 May 2026 | Viewed by 309 | Submission Open

Keywords: antioxidants; bioactive compounds; oxidative stress; structure– activity relationships (SARs); sustainable extraction; green chemistry; therapeutic potential; in vitro and in vivo models; food and biomedical applications

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidants in Health and Disease: Environmental Challenges, Redox Homeostasis, and Adaptive Responses

edited by

Alica Pizent

submission deadline 20 May 2026 | Viewed by 249 | Submission Open

Keywords: antioxidants; redox biology; oxidative stress; environmental exposures; adaptive responses; resilience; Nrf2 pathway; endogenous antioxidants; exogenous antioxidants; cellular homeostasis; environmental toxicology; climate-related stress; human health; chronic disease; prevention; therapeutic strategies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Plant and Algal Antioxidants in Stress Defence

edited by Petra Peharec Štefanić and

Bruno Komazec

submission deadline 20 May 2026 | Viewed by 190 | Submission Open

Keywords: plant antioxidants; algal antioxidants; oxidative stress; bioactive compounds; ROS; abiotic stress; biotic stress; antioxidant enzymes; secondary metabolites; stress physiology; phytochemicals; natural antioxidants

(This special issue belongs to the Section ROS, RNS and RSS)

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