Toward a Clinically Actionable Marker of Systemic Oxidative Stress
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 30 November 2024 | Viewed by 194
Special Issue Editors
Interests: biomarker discovery; liquid chromatography-mass spectrometry; nanoparticles; cardiovascular disease; biostatistics; oxidative stress
Interests: biomarker discovery; quantitiative liquid chromatography–mass spectrometry; cardiovascular disease; chronic diseases; oxidative stress
Special Issue Information
Dear Colleagues,
Oxidative stress plays a vital role in the development of chronic diseases such as cardiovascular complications, cancers, and kidney and liver disease, particularly in the current clinical scenario. Besides stress, hereditary, and lifestyle factors, systemic oxidative stress (SOS) is caused by the excess generation of reactive oxygen species (ROS). Recent findings indicate that the aberrant activation of several biochemical pathways often produces promising and actionable clinical biomarkers of oxidative stress and related molecules. Small-molecule metabolites within the cells, biofluids, and tissues or organisms are often deregulated during both acute and chronic pathological conditions.
Therefore, understanding the complex interactions that occur within a biological system is of paramount importance. In this context, advancements in liquid chromatography coupled to triple quadrupole mass spectrometry (LC/MS) in the multiple reaction monitoring (MRM) mode, which are highly sensitive and specific, are routinely used to probe biological extracts containing various classes of metabolites and those related to oxidative stress.
In this Special Issue, we aim to gather original research and methods articles that utilize hydrophilic interaction (HILIC), hydrophobic C18 and other chromatographic methods in conjunction with mass spectrometry (LC/MS) to analyze the various classes of oxidative stress-related metabolic biomarkers. The overarching aim of this Special Issue is to streamline methods that screen large clinical cohorts rapidly and to identify and validate novel actionable biomarkers that stratify patients’ conditions and enhance therapeutic interventions, drug monitoring, and personalized medicine.
Prof. Dr. Chester Lee Drum
Guest Editor
Dr. Leroy Sivappiragasam Pakkiri
Guest Editor Assistant
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Keywords
- liquid chromatography–triple quadrupole mass spectrometry (LC/MS)
- biomarker discovery
- chronic diseases
- multiple reaction monitoring (MRM)
- oxidative stress
- reactive oxygen species (ROS)
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