Reactive Oxygen Species as a Link Between Metabolic and Cardiovascular Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 9 December 2024 | Viewed by 245
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cardiovascular and metabolic disease comprise overlapping entities with shared underlying pathogenic mechanisms. Redox signalling is a key component of multiple cardiovascular processes, including endothelial function, inflammation, myocardial energetics and arrhythmogenesis. Importantly, oxidative stress may be propagated by metabolic stimuli such as nutrient overload and hormonal signalling via insulin and other adipocytokines secreted by dysfunctional adipose tissue in the context of obesity. This suggests a potential mechanistic link of cardiovascular disease with metabolic entities such as obesity, insulin resistance and diabetes, via reactive oxygen species regulation. Recent evidence suggests that metabolically active interventions, such as antidiabetic or anti-obesity medications, may have direct pleiotropic effects on cardiovascular redox state. Such effects may be clinically important as a means of indirect cardiovascular redox regulation, considering that direct pharmacological targeting of cardiovascular reactive oxygen species remains challenging from a therapeutic perspective. Individualised precision medicine approaches dictate an ongoing need for comprehensive characterisation of the interplay between metabolic and cardiovascular disease, and novel -omics methodologies (such as metabolomic and transcriptomic phenotyping of the cardiovascular system and adipose tissue) are currently providing novel insights into the determinants and consequences of reactive oxygen species in this context.
This Special Issue aims at comprehensively revisiting the role of reactive oxygen species in a range of cardiovascular disease phenotypes, such as atherosclerosis and atrial fibrillation, whilst evaluating the contribution of metabolic disease stimuli in regulating the cardiovascular redox state.
Dr. Ioannis Akoumianakis
Guest Editor
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Keywords
- reactive oxygen species
- oxidative stress
- cardiovascular disease
- endothelial dysfunction
- atherosclerosis
- atrial fibrillation
- diabetes
- insulin resistance
- obesity
- adipose tissue biology
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