Metabolic Dysfunction and Oxidative Stress
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 35
Special Issue Editors
Interests: cell biology; mitochondria; free radicals; antioxidants; iron metabolism; metabolic dysregulation; alcohol; liver disorders; lipid metabolism
Special Issues, Collections and Topics in MDPI journals
Interests: iron metabolism; nutraceuticals; antioxidants; mitochondrial dysfunction; oxidative stress; obesity; satiety; type 2 diabetes; drug delivery; nanoformulations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In this Special Issue, we critically explore and discuss the relationship between oxidative stress and metabolic dysfunction. The imbalance in radical production and the body’s inability to scavenge radicals through antioxidants and antioxidant–enzyme pathways occur in a variety of conditions, namely diabetes, fatty liver disease, hemochromatosis, and mitochondrial diseases. Indeed, mitochondrial dysfunction is involved in cancer, Parkinsons, Alzheimer’s and cardiovascular diseases. Furthermore, iron dysregulation has a central role in many of the aforementioned disorders. The detrimental role of excessive free-iron-mediated oxidative stress in the development of disease states such as fatty liver disease (metabolic and/or alcohol misuse) and diabetes is still an area of intense investigation.
Determining the underlying mechanisms will be pivotal to ‘unfolding’ pathophysiological pathways, potentially discovering new therapeutic avenues and offering insights into novel biomarkers to detect the early onset of a multitude of disorders.
In this Special Issue, we invite researchers to provide original research articles, clinical reports, and review articles that relate to molecular mechanisms and therapeutics or diagnostic strategies focusing on oxidative stress and organelle and cellular dysfunction linked to metabolic dysfunction. We welcome studies involving cellular and animal models as well as human participants, and those exploring innovative supplementation or intervention approaches, such as antioxidant delivery systems and novel molecules.
We believe that this Special Issue will significantly enhance our current understanding of oxidative stress, cellular dysfunction, and progression to disease states.
Dr. Vinood B. Patel
Prof. Dr. Mohammed Gulrez Zariwala
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- iron
- mitochondria
- oxidative stress
- inflammation
- metabolism
- free radicals
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