Oxidative Stress and Redox Signaling in Cancer Progression and Therapy
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 15 December 2024 | Viewed by 649
Special Issue Editors
Interests: cancer biology; oxidative stress; ROS; cancer metabolism
Interests: cancer; autophagy; ROS; transcription factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Compared to their normal counterparts, cancer cells often exhibit higher levels of intracellular reactive oxygen species (ROS), the byproducts of metabolic processes. It is well known that the excessive accumulation of ROS plays a cytotoxic role by causing oxidative damage to biomolecules and organelles. In order to cope with ROS-induced oxidative stress, cancer cells employ powerful enzymatic and non-enzymatic antioxidant systems to ensure that ROS levels are maintained below the detrimental threshold. In addition, the oxidative damage of biomolecules and organelles can be repaired or removed by various mechanisms, including autophagy, proteasomal degradation, and the DNA damage response. This cancer-specific redox homeostasis supports cancer progression by promoting cell survival, growth, metastasis, and therapeutic resistance. Specifically, ROS below the detrimental threshold levels can act as signaling molecules to manipulate redox signaling by directly (oxidative post-translational modifications, termed oxPTMs) or indirectly (other PTMs) affecting protein functions, thereby participating in the regulation of various biological events in cancer.
Given the cytotoxic roles of ROS, a variety of strategies promoting ROS accumulation above the detrimental threshold have been extensively explored for cancer treatment. Nevertheless, a variety of synthetic or natural antioxidants that disturb global redox signaling have also been investigated for their potential utilization in cancer prevention and therapy. In this Special Issue of Antioxidants, original research or review articles that discuss oxidative stress and redox signaling in cancer progression and therapy are welcome.
Prof. Dr. Kui Wang
Prof. Dr. Yunlong Lei
Guest Editors
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Keywords
- ROS
- oxidative stress
- redox signaling
- cancer
- antioxidants
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