Oxidative Stress in Age-Related Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 12 December 2024 | Viewed by 137
Special Issue Editor
Interests: aging; frailty; nutritional interventions; neuroprotection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The understanding of the role of free radicals in aging has undergone significant revisions. Traditionally, the mitochondrial free radical theory of aging (FRTA), proposed by Harman in 1965, implicated reactive oxygen species (ROS) as the primary culprits in cellular aging due to their production exceeding the body’s antioxidant defenses. However, studies in various animal models have revealed no consistent correlation between ROS levels and lifespan, prompting a paradigm shift in our comprehension of ROS functions. It is now recognized that ROS play a pivotal signaling role, activating compensatory homeostatic responses within cells. During aging, elevated ROS levels initially trigger these protective mechanisms, but beyond a certain threshold, they contribute to cellular damage and exacerbate age-related pathologies. Experimental data have demonstrated that oxidative damage correlates more closely with frailty than with chronological age, leading to the formulation of the free radical theory of frailty.
This Special Issue explores the interplay between redox modulation and age-related diseases, with a particular focus on frailty. By integrating findings from both experimental animal models and human cohorts, we aim to advance our understanding of oxidative stress and its role in the progression of diseases associated with aging and frailty, paving the way for innovative therapeutic strategies.
Dr. Gloria Olaso-Gonzalez
Guest Editor
Manuscript Submission Information
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Keywords
- aging
- age-related diseases
- frailty
- oxidative stress
- reductive stress
- redox homeostasis
- antioxidants
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