Oxidative Stress in Neurological Aging
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 69
Special Issue Editors
Interests: oxidative stress; redox signaling; nuclear factor erythroid 2-related factor 2 (NRF2); neurodegenerative disease; skin disease; HPA axis; skin–brain axis; supplements and functional foods
Special Issues, Collections and Topics in MDPI journals
Interests: neuro-immune axis; skin pharmacology; oxidative stress; medicinal herbs; epidermal nerve fibers
Special Issues, Collections and Topics in MDPI journals
Interests: natural products chemistry; pharmaceutical biology; microbial chemistry; hormone dysregulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aging refers to the phenomenon where damage accumulates in cells or tissues over time, leading to decreased function or malfunction. This is particularly pronounced in tissues composed of post-mitotic cells, such as the brain, which do not undergo cell division anymore and are thus more susceptible to cellular damage caused by aging. Representative degenerative neurological disorders include Alzheimer's disease (AD) and Parkinson's disease (PD). Numerous studies have shown that the rate of aging can be influenced, and the genetic pathways and biochemical mechanisms involved in this process are evolutionarily conserved.
Examining the characteristics of cellular changes due to aging, we can summarize them into nine main features: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion, and altered intercellular communication. Research into drug discovery aimed at improving age-related diseases is currently active. Notably, research on NAD+ activation, a major biomarker of mitochondrial dysfunction, has shown promising effects on neurodegeneration improvement.
This Special Issue targets various issues proposed as strategies to suppress neurological aging. It aims to provide insights into how future technologies could control human aging, not only extending lifespan but also enhancing health by minimizing side effects. This development directly relates to improving both individual and societal health, offering substantial benefits.
Dr. Gunhyuk Park
Dr. Hye-Sun Lim
Dr. Yongung Kim
Guest Editors
Manuscript Submission Information
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Keywords
- antioxidants
- neuron
- medicinal herbs
- therapeutic effects
- aging
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