Role of Oxidative Stress, Metabolic and Inflammatory Processes in Platelet Activation: A Contribution from the Italian Study Group on Platelets (GSP)
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 555
Special Issue Editors
Interests: NADPH oxidase; endothelial dysfunction; atherosclerosis
Special Issues, Collections and Topics in MDPI journals
Interests: cardiovascular disease; atherosclerosis; neurodegenerative disease
Interests: platelet activation; oxidative stress; inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The main role of platelets is to control bleeding and repair vascular damage via thrombosis. Platelets are implicated in atherosclerotic complications such as myocardial infarction, stroke and peripheral arterial disease. Recently, platelets activation has also been studied in other diseases. For example, platelets have also been implicated in tumor metastasis through platelet–tumor cell interactions. There are several mechanisms that promote platelet activation. Oxidative stress is one that plays a pivotal role in platelet activation. Several enzymes that produce reactive oxidant species (ROS), such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase (MPO) and uncoupled nitric oxide synthase (NOS), determine a pro-inflammatory status that could interact with other immune cells and secrete various biochemical mediators to promote several diseases, such as cancer and neurodegenerative disease.
This Special Issue aims to analyze the pathophysiological role of platelet activation in several diseases. We intend to collect papers which investigate the mechanisms associated with platelet activation in relation to oxidative stress, metabolic and inflammatory processes.
Dr. Roberto Carnevale
Prof. Dr. Pasquale Pignatelli
Dr. Vittoria Cammisotto
Guest Editors
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Keywords
- platelet aggregation
- platelet activation
- autophagy
- inflammation
- metabolic dysfunction
- oxidative stress
- NADPH oxidase
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