Heme Oxygenase in Health and Disease: New Insights and Future Directions
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 90
Special Issue Editor
Interests: heme oxygenase in cell and organ dysfunction; heme oxygenase and biliverdin reductase activity; ferroptosis; oxidative stress response
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to announce a Special Issue dedicated to further exploring the critical role of heme oxygenase (HO). Responsible for heme degradation and the generation of unique products—bilirubin, carbon monoxide, and iron—HO has far-reaching implications in various physiological and pathological contexts. This issue aims to present new findings on the enzymatic processes and biological implications of HO and related enzyme systems, as well as their products, including oxidative stress response, ferroptosis, inflammation, cancer, and cellular protection. We invite researchers to submit their latest findings on HO-related topics, such as the following:
- Mechanisms of HO-1 and HO-2 regulation and expression, as well as enzyme activities;
- HO's role in cellular defence mechanisms against oxidative stress;
- Therapeutic potential of HO modulation in diseases like cardiovascular, neurodegenerative, and inflammatory disorders;
- HO’s involvement in immune response and cancer biology;
- The role of HO in ferroptosis and its implications for disease treatment;
- Biological effects of HO-derived products: biliverdin, bilirubin, and carbon monoxide (CO);
- The antioxidative and antiinflammatory role of biliverdin and bilirubin, including its functions in the lipid metabolism;
- Signalling functions of CO and other biatomic gases (such as nitric oxide) involving heme proteins, and their potential therapeutic application.
This issue invites researchers to submit research reports or results of clinical trials and welcomes contributions describing new methodological approaches, or model systems, including animal models for studying therapeutic approaches, as well as reviews aiming at sharing new insights for advancing our understanding of HO's integration into physiological and pathological processes in health and disease.
Dr. J. Catharina Duvigneau
Guest Editor
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Keywords
- enzyme activity
- ferroptosis
- carbon monoxide
- oxidative stress
- reactive oxygen and nitrogen species
- heme proteins
- heme degradation
- heme responsive elements
- heme regulation
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