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Advances in Organic Synthetic Chemistry
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Advances in Organic Synthetic Chemistry

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1481

Special Issue Editor

Dr. José A. González-Delgado

E-Mail Website
Guest Editor
CIQSO—Center for Research in Sustainable Chemistry, Department of Chemistry, University of Huelva, 21071 Huelva, Spain
Interests: organic synthesis; supramolecular chemistry; host–guest chemistry; dyes; photochromics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to invite you to submit to this Special Issue in Applied Sciences, entitled “Advances in Organic Synthetic Chemistry”. We are seeking the latest research on advances and developments in novel methodologies in (bio)functional compound syntheses.

Studies of new reactions or synthetic methodologies are welcome. Manuscripts that focus on novel synthesized compounds for different applications, such as materials, photonics, biology, or electronics, among others, are also encouraged. We also seek submissions that develop protocols or processes that are more sustainable, atom-efficient, and without waste/residues, or that use greener solvents.

Original work highlighting the latest research developments is encouraged; however, review papers and perspective manuscripts are also welcome.

Dr. José A. González-Delgado
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced organic synthesis
  • new synthetic methodologies
  • sustainable processes
  • (bio)functional compounds
  • green synthetic chemistry

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Published Papers (2 papers)

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Research

15 pages, 4610 KiB  
Article
Synthesis, Characterization and Biological Activity Evaluation of Some 1,N-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl) Alkanes
by Andreea-Anda Alexa, Vasile-Nicolae Bercean, Sabina Elena Boncea, Adriana Ledeţi, Valentin Badea, Amalia Ridichie, Marilena Motoc and Ionuţ Ledeţi
Appl. Sci. 2024, 14(14), 6180; https://doi.org/10.3390/app14146180 - 16 Jul 2024
Viewed by 619
Abstract
In this paper, we present the synthesis, characterization and evaluation of antiproliferative activity for four compounds carrying the 4-amino-5-mercapto-1,2,4-triazol-3-yl scaffold. The synthesis of 1,n-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl) alkanes was carried out using as starting reagents the dihydrazides of oxalic, malonic, succinic and adipic acids, using mercaptoacetic [...] Read more.
In this paper, we present the synthesis, characterization and evaluation of antiproliferative activity for four compounds carrying the 4-amino-5-mercapto-1,2,4-triazol-3-yl scaffold. The synthesis of 1,n-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl) alkanes was carried out using as starting reagents the dihydrazides of oxalic, malonic, succinic and adipic acids, using mercaptoacetic acid dianion as a leaving group, by a one-pot synthesis method implemented in our research group for the synthesis of 3-substituted-5-mercapto-1,2,4-triazoles. The compounds were obtained with modest yields (12–60%) but with good purity and were characterized by elemental analysis, FTIR, 1H-NMR and 13C-NMR spectroscopy. Also, the stability of the synthesized bis-triazoles was investigated under controlled thermal stress in a dynamic oxidative atmosphere. The last part of the study consisted of biological activity evaluation, by evaluating the antiproliferative activity against the A375 line (human malignant melanoma), as well as on viability of the BJ fibroblast cell line, using MTT and LDH assays. Full article
(This article belongs to the Special Issue Advances in Organic Synthetic Chemistry)
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21 pages, 8911 KiB  
Article
Aromatic Amines in Organic Synthesis Part III; p-Aminocinnamic Acids and Their Methyl Esters
by Marek Pietrzak and Beata Jędrzejewska
Appl. Sci. 2024, 14(14), 6032; https://doi.org/10.3390/app14146032 - 10 Jul 2024
Viewed by 578
Abstract
Fifteen amine derivatives of cinnamic acid were synthesized by reaction of the corresponding benzaldehydes and malonic acid. The selected acids were then converted into methyl esters. Three esterification methods were tested with (1) thionyl chloride in methanol, (2) sulfuric acid in methanol, and [...] Read more.
Fifteen amine derivatives of cinnamic acid were synthesized by reaction of the corresponding benzaldehydes and malonic acid. The selected acids were then converted into methyl esters. Three esterification methods were tested with (1) thionyl chloride in methanol, (2) sulfuric acid in methanol, and (3) dimethyl sulfate in acetone. The latter method turned out to be the best, both in terms of reaction efficiency and product purity. The chemical structure and purity of all the synthesized compounds were verified by elemental analysis, 1H and 13C NMR, and IR spectroscopy. The cinnamic acids and their esters, thanks to an extensive system of conjugated double bonds compared to analogous benzoic acids, can be used to obtain dyes for various applications, including non-linear optics and optoelectronics. Therefore, their basic spectroscopic properties are presented as well. Full article
(This article belongs to the Special Issue Advances in Organic Synthetic Chemistry)
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