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Applied Sciences
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Advanced Stem Cell Technology and Regenerative Medicine
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Advanced Stem Cell Technology and Regenerative Medicine

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (1 September 2023) | Viewed by 4345

Special Issue Editors

Dr. Wan Safwani Wan Kamarul Zaman

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Interests: stem cell technology; tissue engineering; regenerative medicine; nature-inspired materials
Dr. Nurul Asma Abdullah

E-Mail Website
Guest Editor
Biomedicine Program, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Interests: stem cells; regenerative medicine; biomaterials; tissue engineering; cell-based therapy; immunomodulation

Special Issue Information

Dear  Colleagues,

The development of stem cell technology and regenerative medicine is advancing rapidly. This is due to the interests of researchers and demands of various stakeholders in this field.

The main aim of stem cell technology and regenerative medicine is to facilitate the repair and growth of damaged tissues or organs. This has led to the development of various treatment methods, the discovery of potential therapies as well as products based on stem cells, and their commercialization potential.

This Special Issue will be dedicated to new and advanced perspectives in stem cell technology and regenerative medicine. The focus will not only be on advanced methods and technologies but also on other related updates, including verifications in animal models and clinical trials.

Dr. Wan Safwani Wan Kamarul Zaman
Dr. Nurul Asma Abdullah
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • regenerative medicine
  • biomaterials
  • animal models
  • clinical trials
  • advanced technology and methods

Published Papers (2 papers)

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Review

33 pages, 2826 KiB  
Review
Osteoarthritis—The Role of Mesenchymal Stem Cells in Cartilage Regeneration
by Robert Gherghel, Luana Andreea Macovei, Maria-Alexandra Burlui, Anca Cardoneanu, Ioana-Irina Rezus, Ioana Ruxandra Mihai and Elena Rezus
Appl. Sci. 2023, 13(19), 10617; https://doi.org/10.3390/app131910617 - 23 Sep 2023
Cited by 1 | Viewed by 1949
Abstract
Osteoarthritis (OA) is a condition that can cause substantial pain, loss of joint function, and a decline in quality of life in patients. Numerous risk factors, including aging, genetics, and injury, have a role in the onset of OA, characterized by structural changes [...] Read more.
Osteoarthritis (OA) is a condition that can cause substantial pain, loss of joint function, and a decline in quality of life in patients. Numerous risk factors, including aging, genetics, and injury, have a role in the onset of OA, characterized by structural changes within the joints. Most therapeutic approaches focus on the symptoms and try to change or improve the structure of the joint tissues. Even so, no treatments have been able to stop or slow the progression of OA or give effective and long-lasting relief of symptoms. In the absence of disease-modifying drugs, regenerative medicine is being investigated as a possible treatment that can change the course of OA by changing the structure of damaged articular cartilage. In regenerative therapy for OA, mesenchymal stem cells (MSCs) have been the mainstay of translational investigations and clinical applications. In recent years, MSCs have been discovered to be an appropriate cell source for treating OA due to their ability to expand rapidly in culture, their nontumorigenic nature, and their ease of collection. MSCs’ anti-inflammatory and immunomodulatory capabilities may provide a more favorable local environment for the regeneration of injured articular cartilage, which was thought to be one of the reasons why they were seen as more suited for OA. In addition to bone marrow, MSCs have also been isolated from adipose tissue, synovium, umbilical cord, cord blood, dental pulp, placenta, periosteum, and skeletal muscle. Adipose tissue and bone marrow are two of the most essential tissues for therapeutic MSCs. Positive preclinical and clinical trial results have shown that, despite current limitations and risks, MSC-based therapy is becoming a promising approach to regenerative medicine in treating OA. Full article
(This article belongs to the Special Issue Advanced Stem Cell Technology and Regenerative Medicine)
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17 pages, 1389 KiB  
Review
Application of Conditioned Medium for In Vitro Modeling and Repair of Respiratory Tissue
by Fairuz Izan Muhammad Firdaus, Ab. Karim Nashihah, Mh. Busra Mohd Fauzi, Maarof Manira, Saim Aminuddin and Yogeswaran Lokanathan
Appl. Sci. 2023, 13(10), 5862; https://doi.org/10.3390/app13105862 - 10 May 2023
Viewed by 1898
Abstract
Background: The idea of exploring respiratory therapy in vitro predominantly guided by cell-secreted substances has gained ground in recent years. A conditioned medium (CM) consists of protein milieu that contains a diverse spectrum of cytokines, chemokines, angiogenic agents, and growth factors. This review [...] Read more.
Background: The idea of exploring respiratory therapy in vitro predominantly guided by cell-secreted substances has gained ground in recent years. A conditioned medium (CM) consists of protein milieu that contains a diverse spectrum of cytokines, chemokines, angiogenic agents, and growth factors. This review evaluated the efficacy of using CM collected in an in vitro respiratory epithelial model. Methods: Twenty-six papers were included in this review: twenty-one cellular response studies on respiratory secretome application and five studies involving animal research. Results: The CM produced by differentiated cells from respiratory and non-respiratory systems, such as mesenchymal stem cells (MSC), exhibited the similar overall effect of improving proliferation and regeneration. Not only could differentiated cells from respiratory tissues increase proliferation, migration, and attachment, but the CM was also able to protect the respiratory epithelium against cytotoxicity. Most non-respiratory tissue CM was used as a treatment model to determine the effects of the therapy, while only one study used particle-based CM and reported decreased epithelial cell tight junctions, which harmed the epithelial barrier. Conclusion: As it resolves the challenges related to cell development and wound healing while simultaneously generally reducing the danger of immunological compatibility and tumorigenicity, CM might be a potential regenerative therapy in numerous respiratory illnesses. However, additional research is required to justify using CM in respiratory epithelium clinical practice. Full article
(This article belongs to the Special Issue Advanced Stem Cell Technology and Regenerative Medicine)
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