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Applied Sciences
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Advances in Bone Metabolism, Remodeling and Regeneration
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Advances in Bone Metabolism, Remodeling and Regeneration

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 881

Special Issue Editor

Dr. Marek Bienko

E-Mail Website
Guest Editor
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-950 Lublin, Poland
Interests: bone physiology; animal physiology; densitometry; toxicology; biomechanics; environmental ‎threats
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bone metabolism and bone regeneration are two interconnected processes that are crucial for maintaining healthy bone structure and function.

Bone metabolism is a continuous, dynamic process that maintains the balance between bone formation and bone resorption. It plays a vital role in maintaining bone strength, structural integrity, and mineral homeostasis in the body. The key components of bone metabolism include bone formation and resorption. The balance between these processes ensures the maintenance of healthy bone mass and density. Dysregulation can lead to conditions such as osteoporosis (increased bone resorption) or osteopetrosis (decreased bone resorption).

Bone regeneration is the body's natural process of healing and restoring bone tissue following injury, fracture, or surgery. Bone has a unique ability to regenerate and fully recover its original form and function.

Several processes and factors influence bone metabolism and regeneration, affecting how bones are maintained, repaired, and renewed. These include hormonal regulation, nutritional status, mechanical forces, genetics, aging, medications, environmental and lifestyle factors, and systemic health conditions. Each of these factors plays a significant role in the regulation of bone metabolism and the ability of bones to regenerate, highlighting the complex interplay between internal and external influences on bone health.

This Special Issue aims to improve our understanding of new factors that influence bone metabolism and regeneration and which may also be new factors that can treat disorders of the skeletal system.

Dr. Marek Bienko
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone metabolism
  • bone regeneration
  • bone development
  • bone disorders
  • animal research
  • human studies

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Published Papers (1 paper)

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Research

14 pages, 634 KiB  
Article
The Influence of Vitamin D Levels and Supplementation on the Treatment of Patients Affected by MRONJ
by Filip Michalak, Marzena Dominiak, Jan Kiryk, Paweł Popecki, Dominik Kubicki, Jacek Matys and Kinga Grzech-Leśniak
Appl. Sci. 2025, 15(2), 670; https://doi.org/10.3390/app15020670 - 11 Jan 2025
Viewed by 660
Abstract
Background: Advancements in pharmacology have led to the introduction of novel antiresorptive and antiangiogenic drugs, which are associated with the side effect of medication-related osteonecrosis of the jaw (MRONJ). The aim of this study was to evaluate the impact of different blood levels [...] Read more.
Background: Advancements in pharmacology have led to the introduction of novel antiresorptive and antiangiogenic drugs, which are associated with the side effect of medication-related osteonecrosis of the jaw (MRONJ). The aim of this study was to evaluate the impact of different blood levels of vitamin D on the course of treatment, as well as the role of vitamin D supplementation during the treatment of primary diseases involving bisphosphonates or denosumab. Methods: The clinical trial involved 64 patients diagnosed with medication-related osteonecrosis of the jaw (MRONJ) treated at the Department of Oral Surgery. Participants underwent baseline panoramic radiographs and Cone Beam Computed Tomography (CBCT) scans, with MRONJ severity categorized according to the AAOMS classification. This study included two groups: 37 patients (n = 37) in the experimental group received high-dose vitamin D supplementation (10,000 IU/day for 4 weeks, followed by a maintenance dose of 5000 IU/day), while 27 patients (n = 27) in the control group received no supplementation. Vitamin D levels were measured at baseline, 3 months, and 6 months, and the relationship between vitamin D supplementation and clinical outcomes, including MRONJ risk and healing, was evaluated. All participants received an antibiotic regimen pre- and post-surgery. Pain intensity was assessed at multiple time points using the Visual Analog Scale (VAS). Results: This study showed significant increases in serum vitamin D levels in the experimental group at 3 and 6 months (p < 0.05). In the prophylactic context, Vitamin D supplementation prior to or during tooth extraction reduced the risk of developing severe MJRON (OR = 68.57; p < 0.001). In the therapeutic context among patients with established MJRON, vitamin D supplementation did not significantly predict postoperative complications (p = 0.079) or complete healing (OR = 2.34; p = 0.051). However, overall healing rates were somewhat higher in the supplemented group, though they did not reach statistical significance. Antibiotic protection uses also reduced the need for further treatment (OR = 6.20; p < 0.001). Conclusions: Prophylactic high-dose vitamin D supplementation may help prevent severe MRONJ in at-risk patients undergoing tooth extraction. Once MRONJ is established, however, vitamin D alone may not significantly alter immediate postoperative outcomes, although further research is needed to clarify its potential adjunctive benefits. Full article
(This article belongs to the Special Issue Advances in Bone Metabolism, Remodeling and Regeneration)
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