applsci-logo

Journal Browser

Journal Browser

Microbiology and Antibiotic Resistance in the Environment

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Environmental Sciences".

Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 7281

Special Issue Editors


E-Mail Website
Guest Editor
College of Ecology and Environment, East China Normal University, Shanghai 200241, China
Interests: antimicrobial resistance; microbiome; One Health approach

E-Mail Website
Guest Editor
School of Water Resources and Environment, China University of Geosciences (Beijing), Beijing 100083, China
Interests: antibiotic resistome; soil–groundwater systems; co-selection; mobile genetic elements

Special Issue Information

Dear Colleagues,

Antibiotics and antibiotic resistance genes (ARGs) are ancient and naturally occurring substances. Nevertheless, the abuse, overuse, and misuse of antibiotics in humans and animals have stimulated the rapid emergence of antibiotic-resistant bacteria (ARB) and ARGs in various environments such as water, soil, and air. The antibiotic resistance (AR) burden in the environment has serious implications for human health owing to the potential transfer of ARGs from environmental bacteria to human pathogens, and thus highlighting it as an ecological and evolutionary problem that needs to be tackled on multiple fronts, including animal health, human health, environmental pollution, microbial ecology, agriculture, and waste treatment. There is clear value in understanding the occurrence, transmission, and evolution of antibiotic resistance in the environment. Effective treatment technology and interventions for mitigating environmental antibiotics and ARGs are also important to control the spread of ARGs in the environment and solve the relevant global environmental issues.

The topics of interest for this Special Issue include, but are not limited to, the following:

  • The occurrence and transmission of antibiotic resistance determinants (antibiotic resistance genes, antibiotic-resistant bacteria, and mobile genetic elements) in multiple environmental settings;
  • Characterization of acquired antibiotic resistance in different environments;
  • The role of the environment, particularly anthropogenic input, in the evolution and development of antibiotic resistance;
  • Human health risk assessment for environmental development and transfer of antibiotic resistance;
  • Mitigation approaches or strategies to combat antibiotic resistance;
  • Advanced technologies for research on the above topics.

Prof. Dr. Siyu Zhang
Prof. Dr. Yi Zhao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotic resistance

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 2698 KiB  
Article
Screening for Antibacterial Activity of French Mushrooms against Pathogenic and Multidrug Resistant Bacteria
by Clément Huguet, Mélanie Bourjot, Jean-Michel Bellanger, Gilles Prévost and Aurélie Urbain
Appl. Sci. 2022, 12(10), 5229; https://doi.org/10.3390/app12105229 - 21 May 2022
Cited by 7 | Viewed by 2733
Abstract
In the alarming context of antibiotic resistance, we explored the antibacterial potential of French mushrooms against wild-type and multidrug-resistant (MDR) bacteria. In order to accelerate the discovery of promising compounds, screenings were carried out by TLC-direct bioautography. A total of 70 extracts from [...] Read more.
In the alarming context of antibiotic resistance, we explored the antibacterial potential of French mushrooms against wild-type and multidrug-resistant (MDR) bacteria. In order to accelerate the discovery of promising compounds, screenings were carried out by TLC-direct bioautography. A total of 70 extracts from 31 mushroom species were evaluated against five wild-type bacteria: Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. This first screening revealed that 95% of the extracts contained antibacterial compounds. Generally, it was observed that EtOAc extracts exhibited more active compounds than methanolic extracts. In addition, all extracts were overall more active against Gram-positive bacteria than against Gram-negative strains. The most promising mushroom extracts were then screened against various multidrug-resistant strains of S. aureus and E. coli. Activity was globally less on MDR strains; however, two mushroom species, Fomitopsis pinicola and Scleroderma citrinum, still contained several compounds inhibiting the growth of these MDR pathogenic bacteria. Stearic acid was identified as a ubiquitous compound contributing to the antibacterial defence of mushrooms. This screening revealed the potential of macromycetes as a source of antibacterial compounds; further assays are necessary to consider fungal compounds as promising drugs to counter antibiotic resistance. Full article
(This article belongs to the Special Issue Microbiology and Antibiotic Resistance in the Environment)
Show Figures

Graphical abstract

14 pages, 1580 KiB  
Article
Bacterial Hosts and Genetic Characteristics of Antibiotic Resistance Genes in Wastewater Treatment Plants of Xinjiang (China) Revealed by Metagenomics
by Ziteng Liu, Junqin Yao, Huiying Ma, Abudukelimu Rukeya, Zenghui Liang, Wenyan Du and Yinguang Chen
Appl. Sci. 2022, 12(6), 3100; https://doi.org/10.3390/app12063100 - 18 Mar 2022
Cited by 8 | Viewed by 3988
Abstract
Antibiotic resistance genes (ARGs) pose a widespread concern for human health and wastewater treatment plants (WWTPs) are considered to be a major source of ARG transmission. In this paper, the potential hosts and genetic characteristics of ARGs in the influent, activated sludge and [...] Read more.
Antibiotic resistance genes (ARGs) pose a widespread concern for human health and wastewater treatment plants (WWTPs) are considered to be a major source of ARG transmission. In this paper, the potential hosts and genetic characteristics of ARGs in the influent, activated sludge and effluent of WWTPs in Xinjiang were studied by metagenomics. Bacitracin resistance gene (bacA), beta-lactamase gene (class A beta-lactamase), multidrug resistance genes (mexD, qacEdelta1), and sulfonamide resistance genes (sul1, and sul2) are persistent antibiotic resistance genes (PARGs). The potential hosts of ARGs were mainly pathogens, with Escherichia coli (12.9%), Acinetobacter johnsonii (8.94%), and Klebsiella pneumoniae (5.30%) accounting for the highest proportions. Chromosomal sequences and plasmid sequences accounted for 42.0% and 22.6% of ARG-carrying contigs (ACCs) in the influent, respectively. Meanwhile, the effluent contained 58.3% of ACCs in plasmids and 8.30% in chromosomes. Bacitracin resistance genes and multidrug resistance genes were mainly carried by chromosomes, while resistance genes for macrolide–lincosamide–streptogramin (MLS), vancomycin, sulfonamide, beta-lactam, tetracycline, chloramphenicol, and aminoglycoside were mainly carried by plasmids. ICEPae690-sul1-qacEdelta1 and ICEPmiChn3-sul2 were stable coexistence structures and heighten the transfer potential of ARGs in the environment. This study provided a clearer picture of host bacterial sources and genetic context of ARGs in the environment. Full article
(This article belongs to the Special Issue Microbiology and Antibiotic Resistance in the Environment)
Show Figures

Figure 1

Back to TopTop