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Applied Sciences
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Advances in Molecular Imaging and Its Biomedical Application
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Advances in Molecular Imaging and Its Biomedical Application

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Optics and Lasers".

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 2165

Special Issue Editor

Dr. Jingqin Chen

E-Mail Website
Guest Editor
Research Laboratory for Biomedical Optics and Molecular Imaging, Chinese Academy of Sciences (CAS) Key Laboratory of Health Informatics, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Interests: medical imaging; nanomedical imaging probe; optical and photoacoustic molecular imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomedical imaging technology has developed rapidly in recent years and now plays an important role in the early diagnosis and treatment of diseases. This Special Issue focuses on cutting-edge developments in various biomedical imaging technologies. We invite authors to submit original papers and reviews that investigate the following topics:

  • Molecular imaging;
  • Medical imaging;
  • Optical and photoacoustic molecular imaging;
  • Ultrasound imaging;
  • Nanomedical imaging probes;
  • Porphyrin-based probes;
  • Molecular probes;
  • In vitro and in vivo imaging applications;
  • Optical coherence tomography;
  • Spectroscopy-based imaging;
  • Emerging biomedical imaging technologies.

Dr. Jingqin Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical imaging
  • optical and photoacoustic molecular imaging
  • nanomedical imaging probes
  • optical coherence tomography
  • spectroscopy-based imaging

Published Papers (2 papers)

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Research

11 pages, 3790 KiB  
Article
Monte Carlo Simulation of Electron Interactions in an MeV-STEM for Thick Frozen Biological Sample Imaging
by Liguo Wang and Xi Yang
Appl. Sci. 2024, 14(5), 1888; https://doi.org/10.3390/app14051888 - 25 Feb 2024
Cited by 1 | Viewed by 765
Abstract
A variety of volume electron microscopy techniques have been developed to visualize thick biological samples. However, the resolution is limited by the sliced section thickness (>30–60 nm). To preserve biological samples in a hydrated state, cryo-focused ion beam scanning electron microscopy has been [...] Read more.
A variety of volume electron microscopy techniques have been developed to visualize thick biological samples. However, the resolution is limited by the sliced section thickness (>30–60 nm). To preserve biological samples in a hydrated state, cryo-focused ion beam scanning electron microscopy has been developed, providing nm resolutions. However, this method is time-consuming, requiring 15–20 h to image a 10 μm thick sample with an 8 nm slice thickness. There is a pressing need for a method that allows the rapid and efficient study of thick biological samples while maintaining nanoscale resolution. The remarkable ability of mega-electron-volt (MeV) electrons to penetrate thick biological samples, even exceeding 10 μm in thickness, while maintaining nanoscale resolution, positions MeV-STEM as a suitable microscopy tool for such applications. Our research delves into understanding the interactions between MeV electrons and frozen biological specimens through Monte Carlo simulations. Single elastic scattering, plural elastic scattering, single inelastic scattering, and plural inelastic scattering events have been simulated. The electron trajectories, the beam profile, and the intensity change of electrons in each category have been investigated. Additionally, the effects of the detector collection angle and the focal position of the electron beam were investigated. As electrons penetrated deeper into the specimen, single and plural elastic scattered electrons diminished, and plural inelastic scattered electrons became dominant, and the beam profile became wider. Even after 10 μm of the specimen, 42% of the MeV electrons were collected within 10 mrad. This confirms that MeV-STEM can be employed to study thick biological samples. Full article
(This article belongs to the Special Issue Advances in Molecular Imaging and Its Biomedical Application)
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14 pages, 3591 KiB  
Article
High-Performance Microcomputing Tomography of Chick Embryo in the Early Stages of Embryogenesis
by Igor Rzhepakovsky, Sergei Piskov, Svetlana Avanesyan, Magomed Shakhbanov, Marina Sizonenko, Lyudmila Timchenko, Mohammad Ali Shariati, Maksim Rebezov and Andrey Nagdalian
Appl. Sci. 2023, 13(19), 10642; https://doi.org/10.3390/app131910642 - 25 Sep 2023
Cited by 1 | Viewed by 1138
Abstract
X-ray contrast techniques were tested on the chick embryos in early periods of embryogenesis. For contrast stain, reagents with radiopacity in various concentrations were used: silver proteinate, eosin, Lugol’s solution (I2KI), phosphomolybdic acid and phosphotungstic acid under heating at 25 °C and 40 [...] Read more.
X-ray contrast techniques were tested on the chick embryos in early periods of embryogenesis. For contrast stain, reagents with radiopacity in various concentrations were used: silver proteinate, eosin, Lugol’s solution (I2KI), phosphomolybdic acid and phosphotungstic acid under heating at 25 °C and 40 °C and exposure for 24 and 48 h. The use of silver proteinate, eosin and I2KI in various concentrations in the contrast of the chick embryo in the early period of embryogenesis did not make it possible to obtain microtomographic results that provide reliable microstructural analysis. The most optimal and effective method of embryo staining at the HH22–HH34 embryonic stages reliably determined the staining of 1% phosphotungstic acid at 40 °C heating and exposure for 24 h. Taking into account the size of the chick embryos and their structures at the HH22–HH34 embryonic stages, the features of the development, location of organs, and the minimum permissible parameters of microtomography for obtaining high-quality and reliable results were determined by the isometric spatial resolution of 8.87 μm, X-ray voltage 50 kV, X-ray current 500 μA, and the use of filters started from Al 0.5 mm. Microtomographic results were obtained, characterized by the appearance of the chick embryo at the HH22–HH34 embryonic stages, and they visualized the locations and structures of the chick embryo organs and provided calculation of their volume and X-ray density. The results of the work open up significant prospects for using the chick embryo at the early embryonic period of embryogenesis as an alternative model for screening teratogenicity. Full article
(This article belongs to the Special Issue Advances in Molecular Imaging and Its Biomedical Application)
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