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Applied Sciences
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Contemporary Pharmacy: Advances and Challenges
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Contemporary Pharmacy: Advances and Challenges

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 1763

Special Issue Editors

Prof. Dr. Aleksander Mendyk

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Guest Editor
Chair of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Jagiellonian University-Medical College, Medyczna 9 St, 30-688 Kraków, Poland
Interests: machine learning; artificial intelligence; pharmaceutical technology; biopharmaceutics; clinical trials; statistics
Special Issues, Collections and Topics in MDPI journals
Dr. Mateusz Kurek

E-Mail Website
Guest Editor
Chair of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Jagiellonian University-Medical College, Medyczna 9 Street, 30-688 Kraków, Poland
Interests: pharmaceutical technology; solid dispersions; hot melt extrusion; 3D printing; particle size distribution
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is intended for the 3rd International Conference on Contemporary Pharmacy Challenges participants: "Enhancing Pharmaceuticals through Interdisciplinary Research" from September 16th to the 18th, 2024, who will prepare enhanced versions of their conference abstracts. Topics will cover general pharmaceutical sciences, physicochemical characterization of amorphous systems, fundamentals of crystallization from amorphous phase, stability of amorphous systems, modeling and simulations in pharmaceutics, solubility and/or dissolution improvement and methods, merging pharmaceutical technologies and dosage forms, colloidal delivery systems for small molecules, biological drugs, and vaccines, industrial issues and cases, and regulatory affairs.

Prof. Dr. Aleksander Mendyk
Dr. Mateusz Kurek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • amorphous systems
  • stability
  • advanced characterization
  • solubility
  • dissolution
  • biological drugs
  • modeling
  • simulation

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Published Papers (2 papers)

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Research

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20 pages, 3589 KB  
Article
Optimization of Impedance-Based Real-Time Assay in xCELLigence RTCA SP16 Device for the Analysis of Fully Differentiated Caco-2 Cells
by Nadia Khan, Magdalena Kurnik-Łucka, Maja Kudrycka, Krzysztof Gil and Gniewomir Latacz
Appl. Sci. 2025, 15(15), 8298; https://doi.org/10.3390/app15158298 - 25 Jul 2025
Viewed by 1144
Abstract
Impedance-based cellular assays allow determination of biological functions of cell populations in real-time by measuring electrical impedance. As compared to end-point assays, such as trans-epithelial electrical resistance assays, for example, they enable fast, non-invasive, and easy detection of cell kinetics—their growth, attachment, and [...] Read more.
Impedance-based cellular assays allow determination of biological functions of cell populations in real-time by measuring electrical impedance. As compared to end-point assays, such as trans-epithelial electrical resistance assays, for example, they enable fast, non-invasive, and easy detection of cell kinetics—their growth, attachment, and interaction can be monitored over time. In our experiment, Caco-2 cells were cultured on E-plates 16. Next, fully differentiated cells were treated with either TNF-α or 3,4-dihydroxy-L-phenylalanine (L-DOPA). We aimed to verify the possibility of real-time testing of the viability, monolayer formation, and integrity (i.e., the presence of a functional and polarized monolayer) of Caco-2 cells by the xCELLigence real-time cell analyzer (RTCA) S16 system (Agilent Technologies). Full article
(This article belongs to the Special Issue Contemporary Pharmacy: Advances and Challenges)
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Review

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29 pages, 2853 KB  
Review
X-Ray Absorption and Emission Spectroscopy in Pharmaceutical Applications: From Local Atomic Structure Elucidation to Protein-Metal Complex Analysis—A Review
by Klaudia Wojtaszek, Krzysztof Tyrała and Ewelina Błońska-Sikora
Appl. Sci. 2025, 15(19), 10784; https://doi.org/10.3390/app151910784 - 7 Oct 2025
Viewed by 241
Abstract
X-ray absorption spectroscopy (XAS) and X-ray emission spectroscopy (XES) are analytical techniques enabling precise analysis of the electronic structure and local atomic environment in chemical compounds and materials. Their application spans materials science, chemistry, biology, and environmental sciences, supporting studies on catalytic mechanisms, [...] Read more.
X-ray absorption spectroscopy (XAS) and X-ray emission spectroscopy (XES) are analytical techniques enabling precise analysis of the electronic structure and local atomic environment in chemical compounds and materials. Their application spans materials science, chemistry, biology, and environmental sciences, supporting studies on catalytic mechanisms, redox processes, and metal speciation. A key advantage of both techniques is element selectivity, allowing the analysis of specific elements without matrix interference. Their high sensitivity to chemical state and coordination enables determination of oxidation states, electronic configuration, and local geometry. These methods are applicable to solids, liquids, and gases without special sample preparation. Modern XAS and XES studies are typically performed using synchrotron radiation, which provides an intense, monochromatic X-ray source and allows advanced in situ and operando experiments. Sub-techniques such as XANES (X-ray absorption near-edge structure), EXAFS (Extended X-ray Absorption Fine Structure), and RIXS (resonant inelastic X-ray scattering) offer enhanced insights into oxidation states, local structure, and electronic excitations. Despite their broad scientific use, applications in pharmaceutical research remain limited. Nevertheless, recent studies highlight their potential in analyzing crystalline active pharmaceutical ingredients (APIs), drug–biomolecule interactions, and differences in drug activity. This review introduces the fundamental aspects of XAS and XES, with an emphasis on practical considerations for pharmaceutical applications, including experimental design and basic spectral interpretation. Full article
(This article belongs to the Special Issue Contemporary Pharmacy: Advances and Challenges)
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