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Research Highlights in Microfluidics

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Fluid Science and Technology".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 7185

Special Issue Editors


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Guest Editor
School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China
Interests: micro/nano robotics; microfluidic devices; acoustic tweezers; micro/nano machines
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Key Laboratory for Micro/Nano Technology and System of Liaoning Province, Dalian University of Technology, Dalian 116024, China
Interests: micro-nano fluids; micro-assembly

Special Issue Information

Dear Colleagues,

We are inviting submissions to a Special Issue of Applied Sciences on Research Highlights in Microfluidics.

Microfluidics is a new technology platform used to manipulate very small amounts of liquids with high accuracy, and is widely used in the research of biological problems. Microfluidic technology has developed rapidly in recent years. It integrates the sample pretreatment, biochemical reaction, sorting and detection processes involved in the fields of chemistry, biology and medicine into a microfluidic chip and provides a powerful research platform for the foundation and application of these fields. Microfluidic chips can process a large number of samples in parallel, and has the advantages of reduced sample consumption, fast detection speed, simple operation, multi-functional integration, small size and easy of transport. In the future, it will play an important role in the biomedical field, especially in vitro diagnosis. In recent years, the research highlights in microfluidic technology have mainly been focused around the research of efficiency promotion, the combination of multiple micro operation methods, chip processing, microfluidic driving, biological signal detection and so on.

In this Special Issue, we invite submissions exploring research highlights and recent advances in microfluidics. Both theoretical and experimental studies are welcome, as well as comprehensive review and survey papers.

Prof. Dr. Xiaoming Liu
Prof. Dr. Zheng Xu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidic devices
  • single-cell analysis
  • cell operation
  • microfabrication
  • micromanipulation
  • disease diagnosis

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Published Papers (2 papers)

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Research

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16 pages, 5342 KiB  
Article
Computational Characterization of Turbulent Flow in a Microfluidic Actuator
by Santiago Laín, Jaime H. Lozano-Parada and Javier Guzmán
Appl. Sci. 2022, 12(7), 3589; https://doi.org/10.3390/app12073589 - 1 Apr 2022
Cited by 4 | Viewed by 2093
Abstract
In this contribution, an unsteady numerical simulation of the flow in a microfluidic oscillator has been performed. The transient turbulent flow inside the device is described by the Unsteady Reynolds Averaged Navier–Stokes equations (URANS) coupled with proper turbulence models. The main characteristics of [...] Read more.
In this contribution, an unsteady numerical simulation of the flow in a microfluidic oscillator has been performed. The transient turbulent flow inside the device is described by the Unsteady Reynolds Averaged Navier–Stokes equations (URANS) coupled with proper turbulence models. The main characteristics of the complex fluid flow inside the device along one oscillation cycle was analyzed in detail, including not only velocity contours but also the pressure and turbulent kinetic energy fields. As a result, two-dimensional simulations provided good estimations of the operating frequency of the fluidic actuator when compared with experimental measurements in a range of Reynolds numbers. Moreover, with the objective of altering the operating frequency of the apparatus and, in order to adapt it to different applications, geometrical modifications of the feedback channels were proposed and evaluated. Finally, a fully three-dimensional simulation was carried out, which allowed for the identification of intricate coherent structures revealing the complexity of the turbulent flow dynamics inside the fluidic oscillator. Full article
(This article belongs to the Special Issue Research Highlights in Microfluidics)
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Review

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19 pages, 6185 KiB  
Review
A Review on Microfluidic Platforms Applied to Nerve Regeneration
by Chuankai Dai, Xiaoming Liu, Rongyu Tang, Jiping He and Tatsuo Arai
Appl. Sci. 2022, 12(7), 3534; https://doi.org/10.3390/app12073534 - 30 Mar 2022
Cited by 5 | Viewed by 4369
Abstract
In recent decades, microfluidics have significantly advanced nerve regeneration research. Microfluidic devices can provide an accurate simulation of in vivo microenvironment for different research purposes such as analyzing myelin growth inhibitory factors, screening drugs, assessing nerve growth factors, and exploring mechanisms of neural [...] Read more.
In recent decades, microfluidics have significantly advanced nerve regeneration research. Microfluidic devices can provide an accurate simulation of in vivo microenvironment for different research purposes such as analyzing myelin growth inhibitory factors, screening drugs, assessing nerve growth factors, and exploring mechanisms of neural injury and regeneration. The microfluidic platform offers technical supports for nerve regeneration that enable precise spatio-temporal control of cells, such as neuron isolation, single-cell manipulation, neural patterning, and axon guidance. In this paper, we review the development and recent advances of microfluidic platforms for nerve regeneration research. Full article
(This article belongs to the Special Issue Research Highlights in Microfluidics)
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