Neuroimaging in Parkinson's Disease
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (20 January 2022) | Viewed by 1717
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neuroimaging is a powerful noninvasive tool that provides in vivo evaluation of pathophysiological substrates unique to Parkinson’s disease (PD), which is a critical step toward identifying potential biomarkers in PD.
Promising applications of neuroimaging continue to elucidate factors specific to PD. Dopamine transporter single-photon emission computed tomography (SPECT) may improve the accuracy of diagnosis if the presence of parkinsonism is uncertain. Magnetic resonance imaging (MRI) and functional MRI (fMRI) studies have shown brain structures and function to be preserved in the early stages of PD and have helped to identify areas that become affected in the advanced stages of PD. Therefore, further studies are needed to describe the longitudinal course of structural and functional change among persons with PD.
One neuroimaging approach increasingly being applied to investigate normal brain function and impairment is network connectivity. Using magnetic resonance spectroscopy (MRS), the convergence of evidence suggests mitochondrial dysfunction is a component in the pathogenesis of PD. Additionally, employing MRS or diffusion-weighted imaging (DWI) to examine brain temperature has revealed pathophysiological relationships between brain temperature and systemic inflammation in PD. Finally, the recent application of diffusion tensor image analysis along the perivascular space (DTI-ALPS) provides an opportunity to examine the glymphatic system and its relationship with systemic oxidative stress as another approach to investigate neuroinflammation in PD.
Despite these innovative applications of neuroimaging techniques, there is currently no clinically accepted neurophysiological biomarker of differential diagnosis, disease severity, predicted disease progression, or treatment monitoring in PD. Moreover, there are multiple disease variants of PD with different prognoses.
The aim of this Special Issue is to provide a comprehensive assessment of innovative applications of neuroimaging techniques in PD.
Dr. Kimberly H. Wood
Guest Editor
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Keywords
- thermometry
- DWI
- DTI-ALPS
- MRS
- PET
- SPECT
- MRI
- fMRI
- connectivity
- atrophy
