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Recent Advances and Innovations in Microfluidics

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Fluid Science and Technology".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1168

Special Issue Editors


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Guest Editor
Queensland Micro- and Nanotechnology Centre, Griffith University, Brisbane, QLD 4111, Australia
Interests: fluid mechanics and thermal engineering; microfluidics and nanofluidics; nanotechnology; microtechnology

E-Mail Website
Guest Editor
Queensland Micro- and Nanotechnology Centre, Griffith University, Brisbane, QLD 4111, Australia
Interests: computational fluid dynamics; blood plasma separation; tri-axial capillary; core–shell droplet
Queensland Micro- and Nanotechnology Centre, Griffith University, Brisbane, QLD 4111, Australia
Interests: microfluidics; lab on a chip; inertial microfluidics; micro/nanoparticle manipulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advancements in microfluidics—such as fluidic integration, interdisciplinary approaches, and miniaturization—have revolutionized system design, broadened applications across multiple fields, and led to more compact, cost-effective, and scalable systems. These developments have significantly enhanced the efficiency and versatility of microfluidic systems, driving progress in biomedical research, chemical analysis, environmental monitoring, food and agriculture production, energy, microelectronics, wearable technology, and materials science.

This Special Issue highlights emerging trends in microfluidics, providing insights into fundamental principles, state-of-the-art fabrication and engineering technologies, and cutting-edge applications. We welcome original research articles and reviews that push the boundaries of microfluidic science and engineering.

Dr. Fariba Malekpour Galogahi
Dr. Haotian Cha
Dr. Jun Zhang
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro- and nanofluidics
  • micro- and nanofabrication
  • fluid dynamics
  • lab-on-a-chip
  • miniaturized systems

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Published Papers (2 papers)

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Research

22 pages, 5543 KB  
Article
Oxidation Stability of SiO2 and TiO2 Nanofluids for High Voltage Insulation
by Samson Okikiola Oparanti, Youssouf Brahami, Issouf Fofana and Reza Jafari
Appl. Sci. 2026, 16(4), 1856; https://doi.org/10.3390/app16041856 - 12 Feb 2026
Viewed by 272
Abstract
Mineral oils are increasingly being replaced by plant-based insulating liquids, known as natural esters, because of their biodegradability and high fire safety characteristic. However, their wider use in high-voltage and unsealed transformer applications is still limited due to concerns about thermo-oxidative stability and [...] Read more.
Mineral oils are increasingly being replaced by plant-based insulating liquids, known as natural esters, because of their biodegradability and high fire safety characteristic. However, their wider use in high-voltage and unsealed transformer applications is still limited due to concerns about thermo-oxidative stability and the relatively limited long-term performance data available compared to mineral oils. This study investigates improving the oxidation stability of natural esters through nanotechnology. A canola-based insulating liquid was used as the base fluid and modified with TiO2 and SiO2 nanoparticles of different sizes. Nanoparticle concentrations ranged from 0.05 to 0.25 wt.%, while Span 80 (sorbitan monooleate, non-ionic surfactant) served as a surfactant to ensure uniform dispersion and long-term colloidal stability. The nanofluids were subjected to accelerated aging to evaluate oxidation resistance, and key properties such as acidity, viscosity, and dissipation factor were monitored throughout the process. Dielectric performance was assessed using AC breakdown voltage testing, with results interpreted through two-parameter Weibull statistics. The TiO2-based nanofluids demonstrated superior thermo-oxidative stability compared to both the base oil and the SiO2-modified samples. Formulations containing smaller TiO2 nanoparticles (5 nm) exhibited the lowest increases in viscosity, acid value, and dissipation factor, indicating strong resistance to degradation under thermal stress. In dielectric performance, SiO2 nanofluids reached 65.8 kV, while TiO2 nanofluids achieved a higher value of 72.4 kV, confirming their greater effectiveness. Although the nanoparticles are not biodegradable, their use at low concentrations significantly enhances the oxidative and dielectric stability of natural esters, helping extend fluid life and reduce dependence on petroleum-based insulating liquids. Full article
(This article belongs to the Special Issue Recent Advances and Innovations in Microfluidics)
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22 pages, 7282 KB  
Article
Solderability Tests Toward Miniaturized Microelectronics: Applicability and Limitations of Micro-Wetting Balance Testing of SnAgCu and SnBi Solders
by Cham Thi Trinh and Steffen Wiese
Appl. Sci. 2026, 16(2), 601; https://doi.org/10.3390/app16020601 - 7 Jan 2026
Viewed by 420
Abstract
This study presents a comprehensive investigation of the micro-wetting behavior of SAC305 and SnBi58 solders on chip components. Micro-wetting balance tests, which employ small solder globules, enable direct evaluation of solder wettability on miniature electronic components such as 1206 chip resistors and 1206 [...] Read more.
This study presents a comprehensive investigation of the micro-wetting behavior of SAC305 and SnBi58 solders on chip components. Micro-wetting balance tests, which employ small solder globules, enable direct evaluation of solder wettability on miniature electronic components such as 1206 chip resistors and 1206 and 0603 chip capacitors. Unlike conventional wetting tests that use large solder baths, the micro-wetting method suppresses excessive solder rise, making it suitable for testing small-scale components. The results demonstrate that micro-wetting testing is a reliable method for evaluating solder wettability on chip components when appropriate globule size, test temperature, and experimental parameters such as immersion depth and speed are carefully controlled. Among the tested conditions, 2 mm diameter solder globules are identified as the optimal choice because they offer improved thermal management and reduced surface oxidation. The wetting times measured for SnBi58 are comparable to those obtained for conventional SAC305 solder, whereas the maximum wetting forces are generally lower. However, micro-wetting curves exhibit noticeable fluctuations, which complicate the analysis of additional parameters, such as maximum wetting force and wetting rate, and limit direct comparison with standard reference values. Full article
(This article belongs to the Special Issue Recent Advances and Innovations in Microfluidics)
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