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Low-Temperature Plasma for Biomedical Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: closed (10 November 2022) | Viewed by 4280

Special Issue Editor


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Guest Editor
Laboratoire Plasma et Conversion d'Energie, University of Toulouse III- Paul Sabatier, F-31062 Toulouse, CEDEX, France
Interests: modeling of basic data (ion-atom collision cross section, atomic and molecular ion mobility and diffusion coefficients, constant rates) for low temperature plasma generator optimization used for several applications (pollution control, biomedicine and spacecraft propulsion), Monte Carlo simulation

Special Issue Information

Dear Colleagues,

The use of low-temperature plasmas in biomedicine has become a well-established field of research and application. In addition to their original direct applications in surgery tool sterilization, wound healing, and blood coagulation, the use of cold plasmas either via direct applications or indirectly using plasma-activated media, for example, in cancerous cell inactivation or seed inhibition in agriculture, has recently emerged as a very promising field of research. In particular, cold plasmas using rare gases as the carrier gas (rare-gas plasmas) have proven their big potential in biomedical applications. Several research groups have been involved for many years in both cold plasma generator diagnostics and/or modeling of plasma reactors dedicated to several applications and, more specifically, to low-temperature plasma biomedical applications. As a complement to experiments, plasma reactor modeling allows quantifying and optimizing the formation of the different active species that play an active role in these different applications. Some of these research groups work in very tight collaboration with hospitals and cancer clinics in order to test the efficiency of rare-gas cold plasma jets in, for example, malignant cancerous cell inactivation. This Special Issue entitled “Low-Temperature Plasma for Biomedical Applications” intends to collect and diffuse both experimental and modeling research of low-temperature plasma for biomedical applications.

Prof. Dr. Malika Benhenni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • low-temperature plasma
  • plasma generator diagnostics
  • modeling
  • cancer therapy
  • sterilization
  • blood coagulation
  • wound healing
  • plasma agriculture

Published Papers (2 papers)

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Research

16 pages, 3882 KiB  
Article
Activation of Tissue Reparative Processes by Glow-Type Plasma Discharges as an Integral Part of the Therapy of Decubital Ulcers
by Sergej V. Belov, Yurij K. Danilejko, Sergey V. Gudkov, Aleksej B. Egorov, Vladimir I. Lukanin, Vladimir B. Tsvetkov, Evgeny L. Altukhov, Marina V. Petrova, Alexey A. Yakovlev, Elkhan G. Osmanov, Mikhail V. Dubinin, Evgenia A. Kogan, Viktor P. Seredin and Aleksandr M. Shulutko
Appl. Sci. 2022, 12(16), 8354; https://doi.org/10.3390/app12168354 - 21 Aug 2022
Cited by 1 | Viewed by 1852
Abstract
The results of a clinical study of the complex treatment of pressure ulcers using the method of activation of reparative processes in tissues by cold plasma discharges initiated by high-frequency current are presented. Activation was carried out with a specialized device generating cold [...] Read more.
The results of a clinical study of the complex treatment of pressure ulcers using the method of activation of reparative processes in tissues by cold plasma discharges initiated by high-frequency current are presented. Activation was carried out with a specialized device generating cold plasma discharges at frequencies of 0.11, 2.64, and 6.78 MHz. It was shown that the process of activation in the skin and muscle tissues of the bedsore zone proceeds most efficiently when using a current with a frequency of 6.78 MHz as compared to currents with a frequency of 2.64 and 0.11 MHz. For a needle electrode with a diameter of 0.3 mm, the optimal exposure parameters were power—(5.0 ± 1.5) W and time—(2.0–3.0) s. The results of the analysis of histological samples, histochemical, and bacteriological analysis confirmed the effect and showed the dynamics of the process of activation of reparative processes in the tissues of the bedsore wound under the influence of cold plasma discharges and a decrease in microbial contamination. The most pronounced effect of activation was formed during the period from 14 to 21 days. The effectiveness of therapy by the method of activation of reparative processes with cold plasma discharges, according to the criterion of the rate of wound healing, ranged from 14 to 16%, depending on the etiology of the decubitus wound. It is concluded that the activation of tissue reparative processes by glow-type plasma discharges as an integral part of the treatment of decubital ulcers is an effective link in the complex treatment of pressure sores. Full article
(This article belongs to the Special Issue Low-Temperature Plasma for Biomedical Applications)
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13 pages, 1809 KiB  
Article
Cold Atmospheric Plasma, Platelet-Rich Plasma, and Nitric Oxide Synthesis Inhibitor: Effects Investigation on an Experimental Model on Rats
by Bogdan Caba, Ioannis Gardikiotis, Ionut Topala, Ilarion Mihaila, Cosmin Teodor Mihai, Catalina Luca, Sorin Pasca, Ioana Cezara Caba, Gabriel Dimitriu, Bogdan Huzum and Ionela Lacramioara Serban
Appl. Sci. 2022, 12(2), 590; https://doi.org/10.3390/app12020590 - 7 Jan 2022
Cited by 4 | Viewed by 1913
Abstract
The evolution of reconstructive methods for defects of the human body cannot yet replace the use of flap surgery. Research is still preoccupied with the ideal techniques for offering the best chances of survival of the flaps. In our study, we investigated the [...] Read more.
The evolution of reconstructive methods for defects of the human body cannot yet replace the use of flap surgery. Research is still preoccupied with the ideal techniques for offering the best chances of survival of the flaps. In our study, we investigated the effects of cold atmospheric plasma (CAP), N-nitro-L-arginine methyl ester (L-NAME), and platelet-rich plasma (PRP) injectable solutions on flap survival using an in vivo model. Twenty-four Wistar rats (four groups) had the McFarlane flap raised and CAP, L-NAME, and PRP substances tested through a single dose subcutaneous injection. The control group had only a saline solution injected. To the best of our knowledge, this is the first study that evaluated a CAP activated solution through injection on flaps. The flap survival rate was determined by clinical examination (photography documented), hematology, thermography, and anatomopathological tests. The image digital analysis performed on the flaps showed that the necrosis area (control—49.64%) was significantly lower for the groups with the three investigated solutions: CAP (14.47%), L-NAME (18.2%), and PRP (23.85%). Thermography exploration revealed less ischemia than the control group on the CAP, L-NAME, and PRP groups as well. Anatomopathological data noted the best degree of angiogenesis on the CAP group, with similar findings on the L-NAME and PRP treated flaps. The blood work did not indicate infection or a strong inflammatory process in any of the subjects. Overall, the study shows that the CAP activated solution has a similar (better) impact on the necrosis rate (compared with other solutions with known effects) when injected on the modified dorsal rat skin flap, and on top of that it can be obtained fast, in unlimited quantities, non-invasively, and through a standardized process. Full article
(This article belongs to the Special Issue Low-Temperature Plasma for Biomedical Applications)
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