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Plasma Medicine at the Intersection of Non-thermal Physical Plasma Chemistry and Biology

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Physics General".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 2817

Special Issue Editors


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Guest Editor
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Interests: non-thermal plasma (NTP) devices for biomedical applications; NTP dose; NTP chemistry; NTP immunotherapy; NTP for cancer treatment; immunogenic cell death; NTP disinfection; anti-viral effects of NTP; safety of NTP
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Interests: human immunodeficiency virus type 1 (HIV-1) latency; HIV-1 treatment and eradication strategies; immunotherapy; non-thermal plasma (NTP); development of NTP devices for biomedical applications; safety and efficacy of NTP-based interventions for infections by human pathogens

Special Issue Information

Dear Colleagues,

Plasma Medicine, which describes the use of non-thermal plasma for treatment of human diseases, has moved beyond the laboratory into clinical trials of promising biomedical applications of plasma and the approval of a small number of plasma-generating devices for clinical use. Biomedical applications of plasma rely heavily on interactions between the biological targets of treatment and chemical species produced by plasma, including reactive oxygen and nitrogen species (RONS). While several research groups are investigating the effects of plasma-generated RONS on cells and tissues, cause-effect relationships have not yet been established. This issue invites submissions that feature multi-disciplinary research spanning basic science, translational research, and clinical studies. Featured studies will address important gaps in our knowledge regarding key factors that influence the desired clinical outcomes, including the mechanism(s) of action that underlie biomedical plasma applications and the definition of a plasma dose that results in efficacy and acceptable safety.

Dr. Vandana Miller
Dr. Fred Krebs
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

12 pages, 2472 KiB  
Article
Surface Treatment of Ultra-High Molecular Weight Polyethylene (UHMWPE) by Cold Atmospheric Plasma (CAP) for Biocompatibility Enhancement
by Jack Turicek, Nicole Ratts, Matey Kaltchev and Nazieh Masoud
Appl. Sci. 2021, 11(4), 1703; https://doi.org/10.3390/app11041703 - 14 Feb 2021
Cited by 9 | Viewed by 2556
Abstract
Ultra-high molecular weight polyethylene (UHMWPE) is one of the most commonly used polymers in joint replacements because of its biologically inert properties and low friction coefficient. However, it has downfalls relating to its wear, adhesion, and lubrication. In this study, UHMWPE samples were [...] Read more.
Ultra-high molecular weight polyethylene (UHMWPE) is one of the most commonly used polymers in joint replacements because of its biologically inert properties and low friction coefficient. However, it has downfalls relating to its wear, adhesion, and lubrication. In this study, UHMWPE samples were treated with a tubular helium cold atmospheric pressure (CAP) plasma source in order to improve three properties of the polymer: (1) its wear resistance, which was characterized by durometer hardness, (2) its lubrication characterized by water contact angle, and (3) its adhesion characterized by both root mean square surface roughness (Rq) and water contact angle. The polymer was treated by two different parts of the plasma plume (the base and the tip) at two different helium flow rates (1 L/min and 2.5 L/min), for different treatment times. Results of the plasma treatment showed a decrease in the contact angle of between 32 and 54 degrees, a significant increase in the roughness by up to 10 times the pristine surface, and no substantial change in the hardness. These improvements to the adhesion and lubrication properties of the polymer examined suggest that the treated surface could be more suitable for use in artificial joints. Full article
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