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Applied Sciences
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Reconstructions in Difficult Settings: Infections and Bone Tumors
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Reconstructions in Difficult Settings: Infections and Bone Tumors

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (10 November 2021) | Viewed by 2341

Special Issue Editors

Dr. Andrea Sambri

E-Mail Website
Guest Editor
IRCCS Policlinico di Sant’Orsola, Bologna, 40138 Bologna, Italy
Interests: orthopedic and trauma surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Massimiliano De Paolis

E-Mail Website
Guest Editor
Orthopaedics and Traumatology Unit—IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy
Interests: orthopaedics; traumatology; custom-made bone reconstruction; muscoloskeletal infections; bone and soft-tissue sarcomas
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Large bone defects may be caused by either bone and prosthetic infections or bone sarcomas. Many reconstructive techniques can be used to restore bone and joints in large bone defects.

Often, the poor quality or quantity of bone does not allow standard prosthetic devices to be implanted or requires large amounts of cadaveric or autologous bone grafts, with related risks and complications.

Today, custom-made prosthesis, as well as newer material such as high porosity trabecular metal, can help in the reconstructive process.

The aim of this Special Issue is to share the personal experience of the groups and authors currently working on articular and periarticular reconstructions in difficult settings.

Dr. Andrea Sambri
Dr. Massimiliano De Paolis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reconstructions
  • pelvis
  • prosthetic joint infection
  • bone tumor
  • sarcoma
  • prosthesis
  • custom-made
  • navigation
  • revision surgery

Published Papers (1 paper)

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Research

13 pages, 4974 KiB  
Article
Assessment of Quality of Life in Patients with Medication-Related Osteonecrosis of the Jaw Following Reconstructive and Restorative Surgery
by Kirill Arturovich Polyakov, Sofia Vladimirovna Popova, Liudmila Sergeevna Shamanaeva, Sergei Yurievich Ivanov, Pavel Sergeevich Petruk and Tatiana Petrovna Ivanyushko
Appl. Sci. 2021, 11(24), 11950; https://doi.org/10.3390/app112411950 - 15 Dec 2021
Viewed by 1925
Abstract
Recently, numerous articles have been published describing atypical lesions of the jaw bones related to treatment with medications based on phosphorus or analogs of its compounds, particularly bisphosphonates. Goal: To conduct a comparative analysis of the quality of life after radical surgery of [...] Read more.
Recently, numerous articles have been published describing atypical lesions of the jaw bones related to treatment with medications based on phosphorus or analogs of its compounds, particularly bisphosphonates. Goal: To conduct a comparative analysis of the quality of life after radical surgery of the jaw in patients with medication-related osteonecrosis. A total of 82 patients were interviewed, of which 39 (47.6%) patients were in the control group (conservative treatment) and 43 (52.4%) patients in the main group had radical surgical treatment. The mean age of patients in both groups was 66.8 ± 10.03 years. Treatment of patients in the control group in terms of conventional conservative protocol included the local application of 0.05% chlorhexidine solution 1–2 times a day, antibacterial therapy (clindamycin—150 mg 4 times daily for 7 days) and NSAIDs (nimesulide). Patients in the main group (n = 43) underwent segmental resection of the jaw. Thirty days and then 6 months after the treatment, all patients were asked to assess the intensity of pain using a numerical scale, where 0 = no pain, 5 = moderate pain and 10 = the most severe pain imaginable, and to fill in the SF-36 Quality of Life Questionnaire. Results: An analysis of the results obtained with the Numeric Pain Rating Scale demonstrated that the mean pain intensity before treatment was 8.9 points in the control group, and 9.7 in the main group. These values were indicative of “unbearable pain”. After treatment (30 days), the pain score in the control group decreased and amounted to 4.1, which is evidence of the persistence of “moderate pain” in patients. In patients who underwent segmental jaw resection, the mean pain intensity was 0.5. There was no relationship with gender, but there was a direct relationship between the intensity of the pain and the stage of the process (CI = 95%). The SF-36 quality of life questionnaire showed that in the control group, who were treated conservatively, bodily pain (BoP) decreased from a score of 91.2 to 34.3, and the mental health score increased from 34.2 before treatment to 36.3 after treatment, which indicates the persistence of discomfort. The remaining parameters improved after treatment, but no complete recovery was achieved. Before radical surgery, the main group of patients also had a high level of bodily pain (95.2), but after surgery this decreased to 12.4. The remaining parameters also showed a significant difference before and after radical surgery, indicating a positive trend. Radical surgery allows us to improve the quality of life of patients, thereby confirming that surgical volume is a secondary aspect if there is no relapse after the treatment. Full article
(This article belongs to the Special Issue Reconstructions in Difficult Settings: Infections and Bone Tumors)
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