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Smart Materials on the Way to Nanorobots

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: closed (10 July 2021) | Viewed by 2873

Special Issue Editor


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Guest Editor
ICIQ Institute of Chemical Research of Catalonia, University of Chemistry and Technology, Tarragona, Spain
Interests: photocatalysis; micro/nanomotors; energy; environmental remediation

Special Issue Information

Dear Colleagues,

The realization of tiny machines able to autonomously move through a fluid and perform diverse tasks is an important breakthrough in nanotechnology. Since the first works on self-propelled nanomotors reported in the early 2000s, a wide range of materials have been explored as a scaffold for the construction of these nanodevices. It involves the use of passive particles, e.g., polystyrene and silica or active materials that respond to external fields, such as light, magnetic, ultrasound, and electric.

This Special Issue aims to focus on the development of smart materials able to adapt to changes in the environment and/or respond to external stimuli. Such materials will enable the design of new nanomotors with advanced functionalities for applications, in the fields of environmental remediation, biomedicine, sensing, and energy.

Dr. Katherine Villa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomotors
  • polymers
  • photocatalysts
  • metal–organic frameworks
  • magnetic materials
  • biomimetic materials
  • azo compounds

Published Papers (1 paper)

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Research

18 pages, 6490 KiB  
Article
F127/Cisplatin Microemulsions: In Vitro, In Vivo and Computational Studies
by Saman Sargazi, Mohammad Reza Hajinezhad, Mahmood Barani, Mahwash Mukhtar, Abbas Rahdar, Francesco Baino, Pouya Karimi and Sadanand Pandey
Appl. Sci. 2021, 11(7), 3006; https://doi.org/10.3390/app11073006 - 27 Mar 2021
Cited by 18 | Viewed by 2467
Abstract
The development of effective strategies for local administration of chemotherapeutic drugs, thus minimizing the adverse side effects to patients, is one of the key challenges in biomedicine and cancer research. This work reports the formulation and characterization of PluronicF127 microemulsions to enhance the [...] Read more.
The development of effective strategies for local administration of chemotherapeutic drugs, thus minimizing the adverse side effects to patients, is one of the key challenges in biomedicine and cancer research. This work reports the formulation and characterization of PluronicF127 microemulsions to enhance the bioavailability of Cisplatin (Cis). The size of Cis microemulsion was about 12.0 nm, as assessed by dynamic light scattering analysis. In vitro cytotoxic activity of free Cis and F127/Cis microemulsions were studied on malignant (C152 and MCF7) and normal (HUVEC) cells via tetrazolium (MTT) colorimetric assay. Cell morphology was also monitored. In vitro assessments revealed thatF127/Cis microemulsions induced cytotoxicity/morphological changes to a lesser extent than free Cis. Regarding in vivo experiments, F127/Cis microemulsions were injected intraperitoneally at 7 and 14 mg/kg doses into adult male Wistar rats to assess histologic and biochemical changes. In this case, the bulk Cis group caused severe histopathological changes and significant increases in serum liver enzymes and serum kidney function markers. The group treated with the 14 mg/kg dose of F127/Cis microemulsions also showed severe fatty changes and significant increases in serum liver enzymes, blood urea nitrogen, and creatinine levels. The group treated with the low dose of nano-Cis showed a significant increase in serum liver enzymes levels accompanied by mild fatty changes of the liver. Theoretical surveys were performed to get an understanding of the interplay between F127 and Cis. Results reveal that hydrogen bonding (HB) interactions with F127have an influence on the molecular properties of Cis and may playa role in the lower toxicity of F127/Cis in comparison to free Cis. Full article
(This article belongs to the Special Issue Smart Materials on the Way to Nanorobots)
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