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Biomolecules & Bioseparations: From Materials to Emerging Technologies

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 2143

Special Issue Editor


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Guest Editor
Graduate School of Environmental and Life Science, Okayama University, Okayama 700-8530, Japan
Interests: biomaterials; bioseparation; nanobiotechnology; biosensor; biomolecules; biochemistry

Special Issue Information

Dear Colleagues,

This Special Issue, "Biomolecules & Bioseparations: From Materials to Emerging Technologies", focuses on emerging applications of novel methodologies for a mechanistic study on the functions of biomolecules and on bioseparations, including biosensors. For example, a centered topic is the development of methodologies to monitor, scan, and visualize the target phenomena using micro-/nano-scopic or spectroscopic methods, combined with other complemetary techniques (a use of immobilization technique of probes or big data). Advances in bioseparations are the separation and purification of biomacromolecules or pathological factors using lab-on-chip device, microchannel electrophoresis, advanced aqueous two-phase systems, and others. If these characteresitcs are involved, work regarding biomaterials, such as biomimetic and (bio)hybrid materilas, and directed self-assembled biomaterials, will be also centeral topics of this Special Issue.

In the medical field, detecting and separating early stage pathological factors from a patient’s blood is demanded. Key molecules exploited by means of chemical biology, drug discovery, and other omics research have been integrated to emerge a novel platform. For example, a tailored-made multi-functional molecule has opened up new fields in search of de novo or in silico design, and accelerated the integration of novel biosensor and diagosis systems (i.e., a dynamic responsive nature, like soft matter, is required in the mulit-functional molecule.  

Prof. Toshinori Shimanouchi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • bioseparation
  • nanobiotechnology
  • biosensor
  • soft matter
  • dynamic response
  • early-stage diagonosis

Published Papers (1 paper)

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Research

14 pages, 3480 KiB  
Article
Fibril Growth Behavior of Amyloid β on Polymer-Based Planar Membranes: Implications for the Entanglement and Hydration of Polymers
by Toshinori Shimanouchi, Miki Iwamura, Shintaro Deguchi and Yukitaka Kimura
Appl. Sci. 2021, 11(10), 4408; https://doi.org/10.3390/app11104408 - 13 May 2021
Cited by 3 | Viewed by 1797
Abstract
The design of biosensors and artificial organs using biocompatible materials with a low affinity for amyloid β peptide (Aβ) would contribute to the inhibition of fibril growth causing Alzheimer’s disease. We systematically studied the amyloidogenicity of Aβ on various planar membranes. The planar [...] Read more.
The design of biosensors and artificial organs using biocompatible materials with a low affinity for amyloid β peptide (Aβ) would contribute to the inhibition of fibril growth causing Alzheimer’s disease. We systematically studied the amyloidogenicity of Aβ on various planar membranes. The planar membranes were prepared using biocompatible polymers, viz., poly(methyl methacrylate) (PMMA), polysulfone (PSf), poly(L-lactic acid) (PLLA), and polyvinylpyrrolidone (PVP). Phospholipids from biomembranes, viz., 1,2-dioleoyl-phosphatidylcholine (DOPC), 1,2-dipalmitoyl-phosphatidylcholine (DPPC), and polyethylene glycol-graft-phosphatidyl ethanolamine (PEG-PE) were used as controls. Phospholipid- and polymer-based membranes were prepared to determine the kinetics of Aβ fibril formation. Rates of Aβ nucleation on the PSf- and DPPC-based membranes were significantly higher than those on the other membranes. Aβ accumulation, calculated by the change in frequency of a quartz crystal microbalance (QCM), followed the order: PSf > PLLA > DOPC > PMMA, PVP, DPPC, and PEG-PE. Nucleation rates exhibited a positive correlation with the corresponding accumulation (except for the DPPC-based membrane) and a negative correlation with the molecular weight of the polymers. Strong hydration along the polymer backbone and polymer–Aβ entanglement might contribute to the accumulation of Aβ and subsequent fibrillation. Full article
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