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Applied Sciences
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Modelling, analysis, simulation, control, and optimization of bioprocesses in bioreactors
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Modelling, analysis, simulation, control, and optimization of bioprocesses in bioreactors

A special issue of Applied Sciences (ISSN 2076-3417).

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 4106

Special Issue Editor

Prof. Dr. Andreja Gorsek

E-Mail Website
Guest Editor
Laboratory for Process Systems Engineering and Sustainable Development, Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia
Interests: reaction and bioreaction engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioprocess engineering deals with the design and development of equipment and processes for the manufacturing of wide range of products from biological materials. Treatment of waste water is also included in this field. Bioprocess engineering connects mathematics, biology and industrial design, and consists of various spectrums like designing of bioreactors, study of fermentors. It also deals with studying various biotechnological processes used in industries for large scale production of biological products. Bioprocess engineering include the work of mechanical, electrical, and industrial engineers to apply principles of their disciplines to processes based on using living cells or sub-components of such cells. It is becoming an engineering and science discipline with extreme importance and enormous potential.

The most crucial industrial production units in biotechnology are bioreactors. Although the basic operating principle of bioreactors is elementary, a great deal of knowledge of bioreactors is required to ensure the quality, quantity, and economy of the products. In the last decades, we have witnessed intensive research and development, considering the bioreactors of various forms. Investigations in the field of mathematical modelling and control are incredibly important. Dynamic modelling of bioreactors is a challenging problem due to the complexity of cellular metabolisms. The main control objective is to maximize the total production of the desired product. The appropriate strategy for achieving the control objective depends on the bioreactor geometry, bioprocess source media, bioreactor operating mode, the availability of the online measurements, the selected control algorithm, and the accuracy of the dynamic bioreactor model.

It is, therefore, crucial that all employed in the field of bioprocess engineering have enough state-of-the-art knowledge and that they have access to the experiences gained by other engineers and scientists. These are the primary aims of this special issue: Engineers and academics who have discoveries transfer them to others.

The area of the special issue is vast. We expect contributions from the fields of: - bioreactor geometry design, - sensors and actuators for bioreactors, - theoretical and experimental (identification) modeling of bioprocesses in bioreactors, - monitoring and data processing for physical and chemical quantities in bioreactors, - bioreactor control systems with advanced control concepts – new structures and algorithms, - optimization of bioreactors.

Prof. Dr. Andreja Gorsek
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biotechnology
  • Bioprocess engineering
  • Bioreactors
  • Modelling
  • Analysis
  • Simulation
  • Control
  • Sensors
  • Actuators
  • Optimization

Published Papers (2 papers)

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Research

9 pages, 764 KiB  
Article
Biodegradation of a Mixed Manure–Lignocellulosic System—A Possibility Study
by Darja Pečar, Maša Islamčević Razboršek and Andreja Goršek
Appl. Sci. 2021, 11(6), 2489; https://doi.org/10.3390/app11062489 - 11 Mar 2021
Viewed by 1665
Abstract
Animal waste is generated at an increased rate, and its disposal is attracting wide public attention. Anaerobic digestion is considered the most promising option for reducing this waste, and simultaneously, it produces renewable energy. Lignin contained in lignocellulosic biomass is hardly biodegradable, thus [...] Read more.
Animal waste is generated at an increased rate, and its disposal is attracting wide public attention. Anaerobic digestion is considered the most promising option for reducing this waste, and simultaneously, it produces renewable energy. Lignin contained in lignocellulosic biomass is hardly biodegradable, thus pre-treatment has to be considered prior to digestion. The possibility of biological pre-treatment of chicken manure with sawdust using Pleurotus ostreatus fungi was investigated in our study. This animal waste was used as a substrate for further biogas production. To provide a better nutrient balance, we added two different co-substrates, wheat straw and Miscanthus. Mixtures with different mass ratios of chicken manure with sawdust/ordinary wheat straw, as well as chicken manure with sawdust/pre-treated wheat straw were incubated for 30 d. The same experiments were performed with Miscanthus. During incubation, samples were taken at predetermined time intervals, and the concentration of acid-insoluble lignin was determined. Additionally, concentrations of glucose and xylose in the filtrate taken at the end of the Klasson procedure were determined in the initial samples and in the samples after 30 d of incubation. Despite our expectations, almost no lignin degradation was observed. Insignificant decreases in glucose and xylose concentrations after 30 d is attributed to fungi ingestion. Obtained results show that Pleurotus ostreatus, as a white-rot fungi with a unique enzymatic system and as generally preferred organisms for lignin degradation, is, therefore, not suitable for delignification of this particular animal waste. Full article
(This article belongs to the Special Issue Modelling, analysis, simulation, control, and optimization of bioprocesses in bioreactors)
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14 pages, 2765 KiB  
Article
Use of a Heating System to Control the Probiotic Beverage Production in Batch Bioreactor
by Jožef Ritonja, Andreja Goršek and Darja Pečar
Appl. Sci. 2021, 11(1), 84; https://doi.org/10.3390/app11010084 - 24 Dec 2020
Cited by 4 | Viewed by 2050
Abstract
Fermentation is a crucial bioengineering process, existentially important for modern society. The most commonly used production unit for this process is the batch bioreactor. Its main advantage is unsophisticated construction, which unfortunately results in its incapability of controlling the transient state of the [...] Read more.
Fermentation is a crucial bioengineering process, existentially important for modern society. The most commonly used production unit for this process is the batch bioreactor. Its main advantage is unsophisticated construction, which unfortunately results in its incapability of controlling the transient state of the fermentation process. Control of the fermentation can significantly improve the quality of the product and the economy of the process; therefore, it is useful for bioreactors to be equipped with a control system. Based on the experimental results, we used an optimization method to identify a mathematical model that describes the impact of the bioreactor’s temperature on the fermentation’s transient process. The obtained model was applied for the design and synthesis of the closed-loop control system. Simulations and experiments confirmed the effectiveness of the proposed control system. In this way, we can ensure the consistent quality of the produced probiotic product, increase the amount of the product, and shorten the fermentation time. The original results display the feasibility of the closed-loop control of the batch bioreactor’s fermentation process by changing the temperature. So far, the process has been carried without a closed-loop control system. The problem is current and has not yet been solved sufficiently. There are many attempts published; one of the last shows the possibility of controlling the fermentation process by changing the oxygen supply, which is more complex and expensive for realization than the solution from our study. Full article
(This article belongs to the Special Issue Modelling, analysis, simulation, control, and optimization of bioprocesses in bioreactors)
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