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Bioengineering
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Nanoapproaches at the Interface of Treatment, Diagnostics, Bio-Imaging, Drug Delivery...
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Nanoapproaches at the Interface of Treatment, Diagnostics, Bio-Imaging, Drug Delivery and Regenerative Therapeutics

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanotechnology Applications in Bioengineering".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2620

Special Issue Editor

Dr. Mirza Muhammad Faran Ashraf Baig

E-Mail Website
Guest Editor
Assistant Professor (Research), Department of Chemistry, School of Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China
Interests: nanobiotechnology; bioanalytical chemistry; medicinal chemistry; biophysical chemistry; chemical biology

Special Issue Information

Dear Colleagues,

This Special Issue on nanoapproaches welcomes manuscripts related, but not limited, to the following areas:

  • Soft-matter, polymers, nucleic acids, and peptide-based bio-composites for drug delivery and biosensing.
  • Metal alloy nanocomposites with complex core–shell structures for enzyme activity, photothermal effects, and ROS generation.
  • Metal oxide nanostructures with organic interfaces for chemodynamic, and photodynamic therapy.
  • Inorganic quantum dots with semi-conducting properties and structural complexities for bio-catalysis as well as bio-analysis.
  • Coordination complexes, nanomagnets, nanozeolites, and nano-objects with spin-transitions for targeted treatment.
  • Nano-MOFs- and COFs-based molecular hetero-junctions for therapeutic and bio-sensing applications.

Manuscripts incorporating advanced methods and techniques such as magnetic studies, X-rays, “near-field/dark-field/fluorescence/confocal” microscopies, TEM, SEM, NMR, IR, UV, Mass, GC-MS, HPLC, AFM, Raman, plasmonic, nanofluidic, SERS, SPR, neutron scattering, and nanopore-based cellular approaches for solving current biopharmaceutical problems are highly encouraged.

Dr. Mirza Muhammad Faran Ashraf Baig
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanobiotechnology
  • bioanalytical chemistry
  • medicinal chemistry
  • biophysical chemistry
  • chemical biology

Published Papers (2 papers)

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Research

9 pages, 1909 KiB  
Article
On the Structural and Molecular Properties of PEO and PEO-PPG Functionalized Chitosan Nanoparticles for Drug Delivery
by Rejeena Jha, Hyrum Harlow, Mourad Benamara and Robert A. Mayanovic
Bioengineering 2024, 11(4), 372; https://doi.org/10.3390/bioengineering11040372 - 12 Apr 2024
Viewed by 1355
Abstract
Chitosan nanoparticles (CS-NPs) are currently under investigation for a wide range of applications in nanomedicine. We investigated the structural, morphological, and molecular properties of CS-NPs synthesized via ionic gelation and designed specifically for drug delivery. The CS-NPs were prepared at concentrations ranging from [...] Read more.
Chitosan nanoparticles (CS-NPs) are currently under investigation for a wide range of applications in nanomedicine. We investigated the structural, morphological, and molecular properties of CS-NPs synthesized via ionic gelation and designed specifically for drug delivery. The CS-NPs were prepared at concentrations ranging from 0.25 to 1.0% w/v. The 1.0% w/v CS-NPs were also functionalized with polyethylene oxide (PEO) alone and with a diblock copolymer of PEO and polypropylene glycol (PPG). The average nanoparticle size determined from TEM imaging is in the 11.3 to 14.8 nm range. The XRD and TEM analyses reveal a semi-crystalline structure with a degree of crystallinity dependent upon the nature of CS-NP functionalization. Functionalizing with PEO had no effect, whereas functionalizing with PEO-PPG resulted in a significant increase in the crystallinity of the 1.0% w/v CS-NPs. Additionally, the CS/TPP concentration (CS:TPP fixed at a 1:1 ratio) did not impact the degree of crystallinity of the CS-NPs. FTIR analysis confirmed the incorporation of TPP with CS and an increase in hydrogen bonding in more crystalline CS-NPs. Full article
(This article belongs to the Special Issue Nanoapproaches at the Interface of Treatment, Diagnostics, Bio-Imaging, Drug Delivery and Regenerative Therapeutics)
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21 pages, 6567 KiB  
Article
A Nanostructured Protein Filtration Device for Possible Use in the Treatment of Alzheimer’s Disease—Concept and Feasibility after In Vivo Tests
by Thomas Gabriel Schreiner, Manuel Menéndez-González, Maricel Adam, Bogdan Ovidiu Popescu, Andrei Szilagyi, Gabriela Dumitrita Stanciu, Bogdan Ionel Tamba and Romeo Cristian Ciobanu
Bioengineering 2023, 10(11), 1303; https://doi.org/10.3390/bioengineering10111303 - 10 Nov 2023
Viewed by 961
Abstract
Background: Alzheimer’s disease (AD), along with other neurodegenerative disorders, remains a challenge for clinicians, mainly because of the incomplete knowledge surrounding its etiology and inefficient therapeutic options. Considering the central role of amyloid beta (Aβ) in the onset and evolution of AD, Aβ-targeted [...] Read more.
Background: Alzheimer’s disease (AD), along with other neurodegenerative disorders, remains a challenge for clinicians, mainly because of the incomplete knowledge surrounding its etiology and inefficient therapeutic options. Considering the central role of amyloid beta (Aβ) in the onset and evolution of AD, Aβ-targeted therapies are among the most promising research directions. In the context of decreased Aβ elimination from the central nervous system in the AD patient, the authors propose a novel therapeutic approach based on the “Cerebrospinal Fluid Sink Therapeutic Strategy” presented in previous works. This article aims to demonstrate the laborious process of the development and testing of an effective nanoporous ceramic filter, which is the main component of an experimental device capable of filtrating Aβ from the cerebrospinal fluid in an AD mouse model. Methods: First, the authors present the main steps needed to create a functional filtrating nanoporous ceramic filter, which represents the central part of the experimental filtration device. This process included synthesis, functionalization, and quality control of the functionalization, which were performed via various spectroscopy methods and thermal analysis, selectivity measurements, and a biocompatibility assessment. Subsequently, the prototype was implanted in APP/PS1 mice for four weeks, then removed, and the nanoporous ceramic filter was tested for its filtration capacity and potential structural damages. Results: In applying the multi-step protocol, the authors developed a functional Aβ-selective filtration nanoporous ceramic filter that was used within the prototype. All animal models survived the implantation procedure and had no significant adverse effects during the 4-week trial period. Post-treatment analysis of the nanoporous ceramic filter showed significant protein loading, but no complete clogging of the pores. Conclusions: We demonstrated that a nanoporous ceramic filter-based system that filtrates Aβ from the cerebrospinal fluid is a feasible and safe treatment modality in the AD mouse model. The presented prototype has a functional lifespan of around four weeks, highlighting the need to develop advanced nanoporous ceramic filters with anti-biofouling properties to ensure the long-term action of this therapy. Full article
(This article belongs to the Special Issue Nanoapproaches at the Interface of Treatment, Diagnostics, Bio-Imaging, Drug Delivery and Regenerative Therapeutics)
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