New Sights of Machine Learning and Digital Models in Biomedicine

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biosignal Processing".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1128

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Special Issue Information

Dear Colleagues,

This Special Issue explores the intersection of machine learning (ML), digital modeling, and biomedicine, highlighting innovative approaches that leverage advanced computational techniques to enhance medical research, diagnosis, treatment, and patient care.

It includes, but is not limited to, the following fields:

Machine Learning Techniques:

Examination of novel ML algorithms and their applications in biomedicine.

Discussions on supervised, unsupervised, and reinforcement learning techniques tailored for biomedical datasets.

Data Integration and Analysis:

Strategies for integrating vast types of biomedical data, including genomics, proteomics, and patient health records.

Case studies showcasing how data-driven insights lead to breakthroughs in disease understanding and management.

Digital Techniques in Diagnosis:

Computer-aided programs and applications used for diagnosis, Imaging Analysis, Electronic Health Records (EHR), Clinical Decision Support, and innovative digital techniques for diagnostic research.

Clinical Applications:

Real-world applications of ML in diagnostics, predictive analytics, and drug discovery.

The role of ML in improving imaging technologies and pathology.

The Issue features contributions from leading researchers and practitioners in the field, offering a multidisciplinary perspective on the application of machine learning and modeling technologies in healthcare.

The goal of the Special Issue is to provide a comprehensive overview of current advancements, foster collaboration, and inspire future research in the integration of machine learning and digital modeling within biomedicine.

Prof. Dr. Hatem Alhadainy
Guest Editor

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Keywords

  • machine learning
  • biomedical imaging
  • predictive modeling
  • medical data analytics
  • genomics
  • precision medicine
  • bioinformatics
  • machine learning algorithms
  • computer-aided diagnosis
  • imaging analysis
  • clinical decision support
  • electronic health records (EHR)
  • disease prediction simulation models
  • virtual patients
  • drug discovery
  • health informatics

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Published Papers (1 paper)

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Research

15 pages, 1685 KB  
Article
Ultra-High Resolution 9.4T Brain MRI Segmentation via a Newly Engineered Multi-Scale Residual Nested U-Net with Gated Attention
by Aryan Kalluvila, Jay B. Patel and Jason M. Johnson
Bioengineering 2025, 12(10), 1014; https://doi.org/10.3390/bioengineering12101014 - 24 Sep 2025
Viewed by 856
Abstract
A 9.4T brain MRI is the highest resolution MRI scanner in the public market. It offers submillimeter brain imaging with exceptional anatomical detail, making it one of the most powerful tools for detecting subtle structural changes associated with neurological conditions. Current segmentation models [...] Read more.
A 9.4T brain MRI is the highest resolution MRI scanner in the public market. It offers submillimeter brain imaging with exceptional anatomical detail, making it one of the most powerful tools for detecting subtle structural changes associated with neurological conditions. Current segmentation models are optimized for lower-field MRI (1.5T–3T), and they struggle to perform well on 9.4T data. In this study, we present the GA-MS-UNet++, the world’s first deep learning-based model specifically designed for 9.4T brain MRI segmentation. Our model integrates multi-scale residual blocks, gated skip connections, and spatial channel attention mechanisms to improve both local and global feature extraction. The model was trained and evaluated on 12 patients in the UltraCortex 9.4T dataset and benchmarked against four leading segmentation models (Attention U-Net, Nested U-Net, VDSR, and R2UNet). The GA-MS-UNet++ achieved a state-of-the-art performance across both evaluation sets. When tested against manual, radiologist-reviewed ground truth masks, the model achieved a Dice score of 0.93. On a separate test set using SynthSeg-generated masks as the ground truth, the Dice score was 0.89. Across both evaluations, the model achieved an overall accuracy of 97.29%, precision of 90.02%, and recall of 94.00%. Statistical validation using the Wilcoxon signed-rank test (p < 1 × 10−5) and Kruskal–Wallis test (H = 26,281.98, p < 1 × 10−5) confirmed the significance of these results. Qualitative comparisons also showed a near-exact alignment with ground truth masks, particularly in areas such as the ventricles and gray–white matter interfaces. Volumetric validation further demonstrated a high correlation (R2 = 0.90) between the predicted and ground truth brain volumes. Despite the limited annotated data, the GA-MS-UNet++ maintained a strong performance and has the potential for clinical use. This algorithm represents the first publicly available segmentation model for 9.4T imaging, providing a powerful tool for high-resolution brain segmentation and driving progress in automated neuroimaging analysis. Full article
(This article belongs to the Special Issue New Sights of Machine Learning and Digital Models in Biomedicine)
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