Biomedical Engineering Approaches for Non-Invasive Monitoring in Hypovolemia and Hypotension

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biosignal Processing".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 514

Special Issue Editors


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Guest Editor
Organ Support and Automation Technologies Group, U.S. Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA
Interests: biomedical engineering; machine learning; closed-loop control systems; automation; medical imaging; biomedical signal analysis

Special Issue Information

Dear Colleagues,

Monitoring vital signs is crucial for assessing a patient’s condition at every stage of medical care. However, monitoring critical vital signs, such as continuous blood pressure, often requires invasive sensors, which are impractical in pre-hospital or combat casualty care. Furthermore, traditional vital signs can sometimes only provide a partial view of a patient’s condition, as compensatory physiological mechanisms can mask underlying issues. Thus, improved methods are needed to capture continuous non-invasive data when treating traumatic medical conditions.

This Special Issue, titled “Biomedical Engineering Approaches for Non-Invasive Monitoring in Hypovolemia and Hypotension”, features original research papers and comprehensive reviews, highlighting novel methodologies and experimental validation of approaches to non-invasively track a patient’s clinical status. Topics of interest for this Special Issue include, but are not limited to, the following research areas:  

  • Continuous non-invasive vital sign measurement techniques during progressive hypotension, such as those associated with traumatic hemorrhage;
  • Machine learning models for improved physiological tracking of a patient’s clinical condition using non-invasive vital sign measurements;
  • Deep learning artificial intelligence techniques for estimating compensatory status or casualty triage state;
  • Experimental verification and validation of non-invasive blood pressure measurement techniques;
  • In vivo animal or clinical study analysis of advanced monitoring metrics for estimating physiological status.

Any methods or technologies may be considered relevant if they rely on non-invasive monitoring to provide continuous estimations of physiological status and show potential for application in hypotensive and/or hypovolemic patient management.

Dr. Eric J. Snider
Dr. Victor A. Convertino
Guest Editors

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Keywords

  • physiological monitoring
  • non-invasive monitoring
  • blood pressure estimation
  • advanced monitoring
  • machine learning
  • deep learning
  • artificial intelligence

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Published Papers (1 paper)

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Research

19 pages, 3328 KB  
Article
Enhancing Trauma Care: Machine Learning-Based Photoplethysmography Analysis for Estimating Blood Volume During Hemorrhage and Resuscitation
by Jose M. Gonzalez, Lawrence Holland, Sofia I. Hernandez Torres, John G. Arrington, Tina M. Rodgers and Eric J. Snider
Bioengineering 2025, 12(8), 833; https://doi.org/10.3390/bioengineering12080833 - 31 Jul 2025
Viewed by 407
Abstract
Hemorrhage is the leading cause of preventable death in trauma care, requiring rapid and accurate detection to guide effective interventions. Hemorrhagic shock can be masked by underlying compensatory mechanisms, which may lead to delayed decision-making that can compromise casualty care. In this proof-of-concept [...] Read more.
Hemorrhage is the leading cause of preventable death in trauma care, requiring rapid and accurate detection to guide effective interventions. Hemorrhagic shock can be masked by underlying compensatory mechanisms, which may lead to delayed decision-making that can compromise casualty care. In this proof-of-concept study, we aimed to develop and evaluate machine learning models to predict Percent Estimated Blood Loss from a photoplethysmography waveform, offering non-invasive, field deployable solutions. Different model types were tuned and optimized using data captured during a hemorrhage and resuscitation swine study. Through this optimization process, we evaluated different time-lengths of prediction windows, machine learning model architectures, and data normalization approaches. Models were successful at predicting Percent Estimated Blood Loss in blind swine subjects with coefficient of determination values exceeding 0.8. This provides evidence that Percent Estimated Blood Loss can be accurately derived from non-invasive signals, improving its utility for trauma care and casualty triage in the pre-hospital and emergency medicine environment. Full article
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